Gene Information gene info

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GENE：HK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HK1
FullNmae hexokinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4922
EnsembleID ENSG00000156515
Uniprot P19367

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HK1 pyroptosis 37001609 HK1 shRNA transfection further confirmed that HSYA inhibited the NLRP3/GSDMD-mediated pyroptosis via HK1 downregulation. retulator signature
HK1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HK1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HK1 GO:0001678,GO:0002720,GO:0004340,GO:0004340,GO:0004340,GO:0004396,GO:0005515,GO:0005524,GO:0005536,GO:0005739,GO:0005739,GO:0005739,GO:0005741,GO:0005829,GO:0005829,GO:0006002,GO:0006006,GO:0006013,GO:0006096,GO:0006954,GO:0008865,GO:0008865,GO:0019158,GO:0019158,GO:0032731,GO:0042834,GO:0045087,GO:0045121,GO:0046835,GO:0046835,GO:0047931,GO:0051156,GO:0051156,GO:0061621,GO:0072655,GO:0072656

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HK1 hsa:3098 path:hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human)
HK1 hsa:3098 path:hsa00051 Fructose and mannose metabolism - Homo sapiens (human)
HK1 hsa:3098 path:hsa00052 Galactose metabolism - Homo sapiens (human)
HK1 hsa:3098 path:hsa00500 Starch and sucrose metabolism - Homo sapiens (human)
HK1 hsa:3098 path:hsa00520 Amino sugar and nucleotide sugar metabolism - Homo sapiens (human)
HK1 hsa:3098 path:hsa00524 Neomycin, kanamycin and gentamicin biosynthesis - Homo sapiens (human)
HK1 hsa:3098 path:hsa01100 Metabolic pathways - Homo sapiens (human)
HK1 hsa:3098 path:hsa01200 Carbon metabolism - Homo sapiens (human)
HK1 hsa:3098 path:hsa01250 Biosynthesis of nucleotide sugars - Homo sapiens (human)
HK1 hsa:3098 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
HK1 hsa:3098 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
HK1 hsa:3098 path:hsa04930 Type II diabetes mellitus - Homo sapiens (human)
HK1 hsa:3098 path:hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human)
HK1 hsa:3098 path:hsa05131 Shigellosis - Homo sapiens (human)
HK1 hsa:3098 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EGR1 HK1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP HK1 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
AR HK1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 HK1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 HK1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 HK1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 HK1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C HK1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 HK1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 HK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 HK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 HK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 HK1 N/A trascriptional regulation,stimulation inferred by curator TFlink
HIF1A HK1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 HK1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000002103A HK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 HK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C308D HK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000183BED HK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004AC389 HK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016D2D4 HK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 HK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 HK1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
SRC HK1 22135298 phosphorylation N/A PhosphoSite
ULK1 HK1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CDC73 HK1 25348397 N/A physical interaction ComPPI
PLAA HK1 25348397 N/A physical interaction ComPPI
SGTA HK1 25348397 N/A physical interaction ComPPI
PCNA HK1 25348397 N/A physical interaction ComPPI
TOMM22 HK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HK2 HK1 25348397 N/A physical interaction ComPPI
KEAP1 HK1 25348397 N/A physical interaction ComPPI
TUFM HK1 25348397 N/A physical interaction ComPPI
PDCD10 HK1 25348397 N/A physical interaction ComPPI
SRC HK1 24234451 25348397 28054552 physical association anti bait coimmunoprecipitation,cross-linking study ComPPI,IntAct
HIF1A HK1 25348397 N/A physical interaction ComPPI
LIG4 HK1 25348397 N/A physical interaction ComPPI
U2AF2 HK1 25348397 N/A physical interaction ComPPI
TTN HK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NTRK1 HK1 25348397 N/A physical interaction ComPPI
CAV1 HK1 25348397 N/A physical interaction ComPPI
MYC HK1 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CBFA2T3 HK1 25348397 N/A physical interaction ComPPI
NPHP1 HK1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
VDAC1 HK1 10978502 14525934 22304920 24234451 25348397 27898060 physical association cross-linking study,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct,OmniPath
RARS1 HK1 25348397 N/A physical interaction ComPPI
VDAC2 HK1 25348397 27898060 8420959 N/A in vitro ComPPI,OmniPath
CDK2 HK1 25348397 N/A physical interaction ComPPI
EGFR HK1 25348397 N/A physical interaction ComPPI
HEXA HK1 25348397 N/A physical interaction ComPPI
PRKN HK1 25348397 N/A physical interaction ComPPI
NFKB1 HK1 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
CAPN2 HK1 25348397 N/A physical interaction ComPPI
SNCA HK1 25348397 N/A physical interaction ComPPI
ARFGAP1 HK1 25348397 N/A physical interaction ComPPI
NSFL1C HK1 25348397 N/A physical interaction ComPPI
ARF4 HK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AKT1 HK1 25348397 N/A physical interaction ComPPI
TOMM20 HK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GTF3C4 HK1 25348397 N/A physical interaction ComPPI
TPM4 HK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CNTRL HK1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ATF2 HK1 22304920 24234451 25348397 association,physical association anti tag coimmunoprecipitation,cross-linking study,molecular sieving,physical interaction ComPPI,IntAct
MAX HK1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
TES HK1 25348397 N/A physical interaction ComPPI
SCMH1 HK1 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
GNB4 HK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
WDR61 HK1 25348397 N/A physical interaction ComPPI
ATP5F1C HK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
UBA5 HK1 25348397 N/A physical interaction ComPPI
ENO2 HK1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HK1 ATG101 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HK1 NIPSNAP2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HK1 MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HK1 SIRT7 25348397 N/A physical interaction ComPPI
HK1 APP 25348397 N/A physical interaction ComPPI
HK1 FKBP9 25348397 N/A physical interaction ComPPI
HK1 PLPBP 25348397 N/A physical interaction ComPPI
HK1 TUBB2A 25348397 N/A physical interaction ComPPI
HK1 TWF2 25348397 N/A physical interaction ComPPI
HK1 UBXN1 25348397 N/A physical interaction ComPPI
HK1 STAU1 25348397 N/A physical interaction ComPPI
HK1 ASPDH 25348397 N/A physical interaction ComPPI
HK1 HYOU1 25348397 N/A physical interaction ComPPI
HK1 FBF1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
HK1 HKDC1 25348397 N/A physical interaction ComPPI
HK1 ASPSCR1 25348397 N/A physical interaction ComPPI
HK1 HK3 25348397 N/A physical interaction ComPPI
HK1 ARNT 25348397 N/A physical interaction ComPPI
HK1 RETREG1 25348397 N/A two hybrid,physical interaction ComPPI
HK1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
HK1 IFT27 24234451 25348397 27173435 association anti tag coimmunoprecipitation ComPPI,IntAct
HK1 TUBB3 24234451 25348397 27291054 association pull down ComPPI,IntAct
HK1 AIFM1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HK1 COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HK1 MAGED2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HK1 ZFP14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HK1 GRPEL1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HK1 LRRC49 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HK1 HAGH 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HK1 SEC16A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HK1 ANXA2P2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ASL HK1 25348397 N/A physical interaction ComPPI
ECH1 HK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PLGRKT HK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MGST3 HK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HEXB HK1 25348397 N/A physical interaction ComPPI
AHCY HK1 25348397 N/A physical interaction ComPPI
NCOR1 HK1 24234451 26120082 association chromatin immunoprecipitation assay IntAct
HK1 NR1H3 24234451 26120082 association chromatin immunoprecipitation assay IntAct
HK1 NR1H2 24234451 26120082 association chromatin immunoprecipitation assay IntAct
HK1 HK1 24234451 28054552 29568061 association,physical association anti tag coimmunoprecipitation,proximity-dependent biotin identification IntAct
HK1 EEF1A1 24234451 30021884 physical association cross-linking study IntAct
HK1 RSF1 24234451 30021884 physical association cross-linking study IntAct
HK1 DNAH6 24234451 30021884 physical association cross-linking study IntAct
AKT1 HK1 16027165 16892082 17604717 27898060 stimulant N/A OmniPath

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