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GENE：IL10RB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL10RB
FullNmae interleukin 10 receptor subunit beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5965
EnsembleID ENSG00000243646
Uniprot Q08334

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL10RB pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL10RB immunogenic 36579538 Through literature reviews, a total of 108 ICD-related genes were identified (Supplement Table S1). retulator signature
IL10RB ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IL10RB GO:0004920,GO:0004920,GO:0005515,GO:0005886,GO:0006954,GO:0006955,GO:0007165,GO:0016020,GO:0019221,GO:0032002,GO:0038023,GO:0038196,GO:0046427,GO:0051607,GO:0098586,GO:1901857

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL10RB hsa:3588 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL10RB hsa:3588 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
IL10RB hsa:3588 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL10RB hsa:3588 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
IL10RB hsa:3588 path:hsa05152 Tuberculosis - Homo sapiens (human)
IL10RB hsa:3588 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL10 IL10RB 10433356 10542212 10623821 11207245 11485736 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17208301 17404308 19833085 20184663 21115385 21191065 21220452 21840487 23331499 26192618 26755705 7512720 7521688 7543512 9312047 9834059 interaction type,stimulation N/A ACSN,SignaLink
IL10RB IL10RA 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26192618 26755705 7512720 7521688 7543512 9834059 interaction type N/A ACSN
JAK1 IL10RB 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26192618 26755705 7512720 7521688 7543512 9834059 interaction type N/A ACSN
TYK2 IL10RB 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26192618 26755705 7512720 7521688 7543512 9834059 interaction type N/A ACSN
IL10RB STAT3 10433356 10542212 10582086 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 23331499 26192618 26755705 7512720 7521688 7543512 9834059 interaction type,stimulation N/A ACSN,SignaLink
IL26 IL10RB 17208301 23106140 23331499 phosphorylation reaction,stimulation N/A SignaLink,SignaLink
IL10RB IFNLR1 12483210 23331499 inhibition,stimulation N/A SignaLink
IL10RB TYK2 12974481 23331499 stimulation N/A SignaLink
IL10RB JAK1 12974481 23331499 stimulation N/A SignaLink
IFNL1 IL10RB 17208301 23331499 stimulation N/A SignaLink
IFNL2 IL10RB 12469119 17208301 23331499 stimulation N/A SignaLink
IFNL3 IL10RB 12469119 17208301 23331499 stimulation N/A SignaLink
IL22 IL10RB 10875937 17208301 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GATA3 IL10RB 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 IL10RB 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 IL10RB 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 IL10RB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IL10RB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL10RB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 IL10RB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IL10RB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IL10RB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 IL10RB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IL10RB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IL10RB 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000411752 IL10RB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD IL10RB 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000011DF IL10RB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA IL10RB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E IL10RB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 IL10RB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F IL10RB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F IL10RB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000122F23 IL10RB 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000008A99 IL10RB 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000075B538 IL10RB 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
IL10RA IL10RB 25361965 interaction type N/A PTMCode2
IL10RB IL10RA 25361965 interaction type N/A PTMCode2
IL10RB IL22 25361965 interaction type N/A PTMCode2
IL22 IL10RB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UCN2 IL10RB 11416224 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
UCN3 IL10RB 11416224 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
IL22 IL10RB 10875937 12513909 14525934 20462497 24234451 25348397 physical association experimental interaction detection,surface plasmon resonance,physical interaction,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
IL22RA1 IL10RB 15120653 24234451 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
IFNL2 IL10RB 12469119 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IL10RB IL10RA 14525934 25348397 9312047 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
IL10RB IFNL3 12469119 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IL10RB IL10 11485736 12513909 14525934 20462497 24234451 25348397 9312047 physical association cross-linking study,experimental interaction detection,surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,HPRD,IntAct
IL10 IL10RB 10347215 11035029 11485736 20462497 27898060 9312047 stimulant N/A OmniPath
IL10RB IL10RA 15985167 27898060 9312047 N/A N/A OmniPath
IL10RB TYK2 10347215 27898060 stimulant N/A OmniPath
IL22 IL10RB 10875937 17208301 18509351 27898060 stimulant N/A OmniPath
IL26 IL10RB 17208301 27898060 stimulant N/A OmniPath
IL10RB IL22RA1 11035029 15120653 27898060 N/A N/A OmniPath
IL10RB IFNLR1 12974481 27898060 N/A N/A OmniPath
IFNLR1 IL10RB 12974481 27898060 N/A N/A OmniPath
IFNL3 IL10RB 12469119 27898060 stimulant N/A OmniPath
IFNL1 IL10RB 12469119 27898060 stimulant N/A OmniPath
IFNL2 IL10RB 12469119 27898060 stimulant N/A OmniPath

Visualization










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