GENE：INSIG1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | INSIG1 |
| FullNmae | insulin induced gene 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6083 |
| EnsembleID | ENSG00000186480 |
| Uniprot | O15503 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| INSIG1 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| INSIG1 | GO:0005515,GO:0005783,GO:0005783,GO:0005789,GO:0005789,GO:0006641,GO:0006695,GO:0006695,GO:0008142,GO:0010894,GO:0032869,GO:0032933,GO:0032933,GO:0032937,GO:0032937,GO:0036315,GO:0036316,GO:0036316,GO:0042472,GO:0042474,GO:0042632,GO:0045599,GO:0045717,GO:0060021,GO:0060363,GO:0070862,GO:0140311,GO:1901303 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | INSIG1 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ESR1 | INSIG1 | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | INSIG1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | INSIG1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | INSIG1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| HIF1A | INSIG1 | 18971253 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| YBX1 | INSIG1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | INSIG1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | INSIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | INSIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | INSIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | INSIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | INSIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | INSIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | INSIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | INSIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | INSIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | INSIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | INSIG1 | 18185580 20371350 23592263 24398324 25416803 | mrna cleavage,inhibition | array technology,clip | TarBase |
| URS00000F31F4 | INSIG1 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000B59A2 | INSIG1 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000008F0CF | INSIG1 | 20489155 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00002FC5B0 | INSIG1 | 20371350 22473208 23592263 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
| URS00000AA464 | INSIG1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000600E6 | INSIG1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000345DEB | INSIG1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00001A405B | INSIG1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000042E1F | INSIG1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000076995 | INSIG1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272A3D | INSIG1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000045147B | INSIG1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C85B2 | INSIG1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001E96DA | INSIG1 | 20371350 23592263 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B989F | INSIG1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A7F58 | INSIG1 | 22473208 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001FFA8C | INSIG1 | 20371350 21572407 23592263 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000148B91 | INSIG1 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000055128B | INSIG1 | 19536157 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000096022 | INSIG1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001EE123 | INSIG1 | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004AC389 | INSIG1 | 20371350 23592263 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000031BC7D | INSIG1 | 20371350 21572407 23592263 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000015A0D9 | INSIG1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000070CD2 | INSIG1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272A92 | INSIG1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040FA88 | INSIG1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000553F51 | INSIG1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000453664 | INSIG1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000E7139 | INSIG1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001ADE63 | INSIG1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000052EA98 | INSIG1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000080D0A | INSIG1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000058276F | INSIG1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D2680 | INSIG1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004283FE | INSIG1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F859B | INSIG1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000077DDE | INSIG1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005481D | INSIG1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000160683 | INSIG1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A608 | INSIG1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AMFR | INSIG1 | 25361965 | interaction type | N/A | PTMCode2 |
| INSIG1 | AMFR | 25361965 | interaction type | N/A | PTMCode2 |
| SCAP | INSIG1 | 25361965 | interaction type | N/A | PTMCode2 |
| INSIG1 | SCAP | 25361965 | interaction type | N/A | PTMCode2 |
| FAF2 | INSIG1 | 25361965 | interaction type | N/A | PTMCode2 |
| INSIG1 | FAF2 | 25361965 | interaction type | N/A | PTMCode2 |
| HMGCR | INSIG1 | 25361965 | interaction type | N/A | PTMCode2 |
| INSIG1 | HMGCR | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ERLIN1 | INSIG1 | 25348397 | N/A | physical interaction | ComPPI |
| PSMC3 | INSIG1 | 25348397 | N/A | physical interaction | ComPPI |
| VCP | INSIG1 | 25348397 | N/A | physical interaction | ComPPI |
| INSIG2 | INSIG1 | 25348397 | N/A | physical interaction | ComPPI |
| VAPA | INSIG1 | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction,physical interaction | ComPPI |
| SREBF1 | INSIG1 | 25348397 | N/A | physical interaction | ComPPI |
| SREBF2 | INSIG1 | 12242332 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| VAPB | INSIG1 | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction,physical interaction | ComPPI |
| RNF139 | INSIG1 | 20068067 22143767 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| SCAP | INSIG1 | 12202038 12482938 12842885 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| INSIG1 | HMGCR | 12535518 14525934 16168377 19458199 20458442 21343306 23223569 24371122 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
| INSIG1 | FAF2 | 18835813 19815544 23720822 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| INSIG1 | AMFR | 21343306 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| INSIG1 | PSMA7 | 25348397 | N/A | physical interaction | ComPPI |
| INSIG1 | ERLIN2 | 21343306 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| INSIG1 | ELAVL1 | 25348397 | N/A | physical interaction | ComPPI |
| INSIG1 | PGRMC1 | 25348397 | N/A | physical interaction | ComPPI |
| INSIG1 | POR | 25348397 | N/A | physical interaction | ComPPI |
| INSIG1 | CDH13 | 25348397 | N/A | physical interaction | ComPPI |
| BDKRB1 | INSIG1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | INSIG1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| INSIG1 | SERBP1 | 18786561 27898060 | inhibition | N/A | OmniPath |