GENE：MPO
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MPO |
| FullNmae | myeloperoxidase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7218 |
| EnsembleID | ENSG00000005381 |
| Uniprot | P05164 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MPO | netotic_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | retulator signature |
| MPO | netotic_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| MPO | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MPO | GO:0001878,GO:0002149,GO:0002679,GO:0003682,GO:0004601,GO:0004601,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005634,GO:0005654,GO:0005764,GO:0006952,GO:0006979,GO:0008201,GO:0009612,GO:0019430,GO:0020037,GO:0030141,GO:0032094,GO:0032496,GO:0034374,GO:0035578,GO:0042582,GO:0042742,GO:0042744,GO:0043066,GO:0043231,GO:0046872,GO:0050832,GO:0070062,GO:0097013,GO:1990268 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MPO | hsa:4353 | path:hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
| MPO | hsa:4353 | path:hsa04145 | Phagosome - Homo sapiens (human) |
| MPO | hsa:4353 | path:hsa04613 | Neutrophil extracellular trap formation - Homo sapiens (human) |
| MPO | hsa:4353 | path:hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| MPO | hsa:4353 | path:hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RUNX1 | MPO | 20506188 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SMARCA4 | MPO | 20506188 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SMARCB1 | MPO | 20506188 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MPO | PITX3 | 22278372 23180781 | physical association | unspecified method | InnateDB |
| PITX3 | MPO | 22278372 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MPO | SFTPD | 21204009 23180781 | physical association | pull down | InnateDB |
| MPO | SFTPA1 | 21204009 23180781 | physical association | pull down | InnateDB |
| MPO | MYB | 23180781 24121275 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MYC | MPO | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SP1 | MPO | 12057865 17521322 8662930 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| SMARCA4 | MPO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MPO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | MPO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RARA | MPO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | MPO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | MPO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | MPO | 11023523 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | MPO | 12057865 17521322 8662930 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MPO | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPE | MPO | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | MPO | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYB | MPO | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | MPO | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RAD21 | MPO | 25348397 | N/A | physical interaction | ComPPI |
| MPO | CP | 14525934 25348397 27898060 9097926 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| MPO | ICE2 | 25348397 | N/A | physical interaction | ComPPI |
| MPO | FRMD1 | 25348397 | N/A | physical interaction | ComPPI |
| MPO | APCDD1 | 25348397 | N/A | physical interaction | ComPPI |
| MPO | PLB1 | 25348397 | N/A | physical interaction | ComPPI |
| MPO | A2M | 17174955 24234451 25348397 | colocalization | cosedimentation through density gradient | ComPPI,IntAct |
| MPO | MPO | 10766826 11705390 1320128 14525934 7840679 8037771 8718890 | N/A | experimental interaction detection | HPRD |
| CCDC47 | MPO | 24234451 30021884 | physical association | cross-linking study | IntAct |
| HNRNPK | MPO | 24234451 30021884 | physical association | cross-linking study | IntAct |
| CEBPA | MPO | 15676205 27898060 | stimulant | N/A | OmniPath |
| RUNX1 | MPO | 15676205 27898060 | stimulant | N/A | OmniPath |
| MPO | APOA1 | 20043647 27898060 | inhibition,stimulant | N/A | OmniPath |
| KRT1 | MPO | 17591979 27898060 | stimulant | N/A | OmniPath |