GENE：MXD1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MXD1 |
| FullNmae | MAX dimerization protein 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6761 |
| EnsembleID | ENSG00000059728 |
| Uniprot | Q05195 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MXD1 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MXD1 | GO:0000122,GO:0000785,GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006357,GO:0046983,GO:0070443 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MXD1 | BIRC2 | 18082613 23180781 | ubiquitination reaction,physical association | anti tag coimmunoprecipitation,enzymatic study | InnateDB |
| MXD1 | BIRC3 | 18082613 23180781 | ubiquitination reaction | enzymatic study | InnateDB |
| MXD1 | CEBPA | 18203738 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MXD1 | CEBPB | 18203738 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CEBPE | MXD1 | 18203738 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MXD1 | POLR2F | 23180781 23994473 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MXD1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | MXD1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | MXD1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | MXD1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | MXD1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | MXD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MXD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MXD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | MXD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | MXD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | MXD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MXD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | MXD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MXD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | MXD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | MXD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | MXD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD3 | MXD1 | 21345218 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | MXD1 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000006FDD4 | MXD1 | 24675462 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000324096 | MXD1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000031E12 | MXD1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000A07C1 | MXD1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000B1C9 | MXD1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000122ED0 | MXD1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029979D | MXD1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237CBD | MXD1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032EF64 | MXD1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C0099 | MXD1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000076995 | MXD1 | 22815788 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr | TarBase |
| URS0000272A3D | MXD1 | 22815788 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr | TarBase |
| URS000013E79D | MXD1 | 25416803 27520398 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS000000C73C | MXD1 | 22815788 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr | TarBase |
| URS00000DDD35 | MXD1 | 22815788 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr | TarBase |
| URS00001CF056 | MXD1 | 21572407 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B7E30 | MXD1 | 21572407 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000028DE3F | MXD1 | 21572407 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00003FA24D | MXD1 | 21572407 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D8730 | MXD1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000251D0B | MXD1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C11BC | MXD1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001EFBE3 | MXD1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000060B2B | MXD1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001799A3 | MXD1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004719AB | MXD1 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RPS6KA1 | MXD1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| RPS6KB1 | MXD1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| AKT1 | MXD1 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| MLX | MXD1 | 25361965 | interaction type | N/A | PTMCode2 |
| MXD1 | MLX | 25361965 | interaction type | N/A | PTMCode2 |
| MXD1 | AKT1 | 25361965 | interaction type | N/A | PTMCode2 |
| MXD1 | SAP30 | 25361965 | interaction type | N/A | PTMCode2 |
| SAP30 | MXD1 | 25361965 | interaction type | N/A | PTMCode2 |
| MXD1 | MAX | 25361965 | interaction type | N/A | PTMCode2 |
| MAX | MXD1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F6 | MXD1 | 25348397 | N/A | physical interaction | ComPPI |
| RING1 | MXD1 | 25348397 | N/A | physical interaction | ComPPI |
| RYBP | MXD1 | 25348397 | N/A | physical interaction | ComPPI |
| BRMS1 | MXD1 | 25348397 | N/A | physical interaction | ComPPI |
| CD2 | MXD1 | 25348397 | N/A | in vitro,in vivo | ComPPI |
| PRAM1 | MXD1 | 25348397 | N/A | in vivo | ComPPI |
| VDR | MXD1 | 25348397 | N/A | physical interaction | ComPPI |
| UBB | MXD1 | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| UBC | MXD1 | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| RPS27A | MXD1 | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| UBA52 | MXD1 | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| SIN3A | MXD1 | 10551834 11101889 11106735 14525934 15235594 20547842 25348397 26186194 27898060 7889570 | N/A | two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| MYC | MXD1 | 11602341 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| RPS6KA1 | MXD1 | 18451027 24234451 25348397 | N/A | physical interaction,protein kinase assay | ComPPI,IntAct |
| KDM5A | MXD1 | 25348397 | N/A | physical interaction | ComPPI |
| RPS6KB1 | MXD1 | 18451027 24234451 25348397 | N/A | physical interaction,protein kinase assay | ComPPI,IntAct |
| HDAC2 | MXD1 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| MXD1 | SAP30 | 14525934 25348397 7889570 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| MXD1 | SMC3 | 14525934 25348397 9528857 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| MXD1 | SIN3B | 14525934 24234451 24951594 25348397 7889570 | physical association | experimental interaction detection,in vitro,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct |
| MXD1 | PML | 11430826 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| MXD1 | MAX | 10229200 11602341 14525934 17418410 24234451 25348397 27705803 8425218 | association,physical association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification | ComPPI,HPRD,IntAct |
| MXD1 | MYCN | 11602341 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| MXD1 | MYCL | 11602341 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| MXD1 | HDAC1 | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | MLX | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | AKT1 | 18451027 24234451 25348397 | N/A | physical interaction,protein kinase assay | ComPPI,IntAct |
| MXD1 | BIRC2 | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | APP | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | SAP130 | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | BRMS1L | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | SAP30L | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | ARID4B | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | SUDS3 | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | ARID4A | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | TFDP1 | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | MGA | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | PCGF6 | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | CBX3 | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | RNF2 | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | L3MBTL2 | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | YAF2 | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | MXD3 | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | MXD4 | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | MNT | 25348397 | N/A | physical interaction | ComPPI |
| MXD1 | MXD1 | 12553908 14525934 | N/A | experimental interaction detection | HPRD |
| RPS6KA1 | MXD1 | 18451027 27898060 | inhibition | N/A | OmniPath |
| AKT1 | MXD1 | 18451027 19526459 27898060 | inhibition | N/A | OmniPath |
| BIRC2 | MXD1 | 18082613 27898060 | N/A | N/A | OmniPath |
| BIRC3 | MXD1 | 18082613 27898060 | N/A | N/A | OmniPath |
| RPS6KB1 | MXD1 | 18451027 27898060 | inhibition | N/A | OmniPath |
| RPS6KB2 | MXD1 | 18451027 27898060 | inhibition | N/A | OmniPath |