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GENE：PLEKHM1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PLEKHM1
FullNmae pleckstrin homology and RUN domain containing M1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29017
EnsembleID ENSG00000225190
Uniprot Q9Y4G2

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PLEKHM1 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
PLEKHM1 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PLEKHM1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PLEKHM1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PLEKHM1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PLEKHM1 GO:0005515,GO:0005730,GO:0005764,GO:0005765,GO:0015031,GO:0031902,GO:0032418,GO:0032418,GO:0043231,GO:0044754,GO:0045780,GO:0046872,GO:0061909,GO:1900029,GO:1902774

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PLEKHM1 hsa:9842 path:hsa04140 Autophagy - animal - Homo sapiens (human)
PLEKHM1 hsa:9842 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 PLEKHM1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 PLEKHM1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA PLEKHM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PLEKHM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PLEKHM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PLEKHM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PLEKHM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PLEKHM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000600E6 PLEKHM1 23622248 25416803 26701625 mrna cleavage,inhibition clip,clash TarBase
URS0000345DEB PLEKHM1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA PLEKHM1 23622248 25416803 26701625 mrna cleavage,inhibition clip,clash TarBase
URS000022B729 PLEKHM1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000039E1E1 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003E5E03 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000009EA8F PLEKHM1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000042619A PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004F4657 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000016C318 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003E6479 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000010F787 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000042E1F PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002B3783 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001123BD PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001E96DA PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000070CD2 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000346991 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000027080C PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000041E949 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000081D1E PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000014F13C PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002394F5 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000148B91 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000058863C PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000508C13 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001310DE PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000057FDB8 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075BC91 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004E02F2 PLEKHM1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000009265 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000010BD8D PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005F9738 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000BD6DC PLEKHM1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000004BACE PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000015A0D9 PLEKHM1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000047A8F PLEKHM1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000078918 PLEKHM1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00001919B0 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000054A671 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000ECE9C PLEKHM1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00002F0130 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000214763 PLEKHM1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000298BA3 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000021D08 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E1509 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000001A7A PLEKHM1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00004B83FE PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000355E82 PLEKHM1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00002E728C PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000DDD35 PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003AD2AA PLEKHM1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GADD45G PLEKHM1 15383276 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HNRNPL PLEKHM1 25348397 N/A physical interaction ComPPI
MAPK6 PLEKHM1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EIF2S2 PLEKHM1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PAFAH1B3 PLEKHM1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SERPINB9 PLEKHM1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PLEKHM1 BID 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct

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