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GENE：PNO1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PNO1
FullNmae partner of NOB1 homolog
LocusType gene with protein product
Status Approved
HGNC_id HGNC:32790
EnsembleID ENSG00000115946
Uniprot Q9NRX1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PNO1 ferroptosis 36446769 Together, our findings indicated that PNO1 protects HCC cells from ferroptotic death through autophagy-mediated GSH metabolic remodeling, and we identified a candidate therapeutic target that may potentiate the effect of ferroptosis-based antitumor therapy. retulator signature

Go Annotation:

GeneSymbol Go id
PNO1 GO:0003723,GO:0005515,GO:0005654,GO:0005654,GO:0005730,GO:0005730,GO:0005829,GO:0032040,GO:0042274

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EED PNO1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 PNO1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR PNO1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 PNO1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PNO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PNO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PNO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001E0AEA PNO1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000040EC3B PNO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 PNO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EBD4B PNO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C PNO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000237AF9 PNO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD PNO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039A052 PNO1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 PNO1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 PNO1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A PNO1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB0E PNO1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA PNO1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000043C1C3 PNO1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 PNO1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F PNO1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 PNO1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000C85B2 PNO1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 PNO1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC4BD PNO1 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PNO1 NOB1 25361965 interaction type N/A PTMCode2
NOB1 PNO1 25361965 interaction type N/A PTMCode2
PNO1 RIOK2 25361965 interaction type N/A PTMCode2
RIOK2 PNO1 25361965 interaction type N/A PTMCode2
PNO1 PWP2 25361965 interaction type N/A PTMCode2
PWP2 PNO1 25361965 interaction type N/A PTMCode2
PNO1 UTP15 25361965 interaction type N/A PTMCode2
UTP15 PNO1 25361965 interaction type N/A PTMCode2
PNO1 IMP3 25361965 interaction type N/A PTMCode2
IMP3 PNO1 25361965 interaction type N/A PTMCode2
PNO1 BMS1 25361965 interaction type N/A PTMCode2
BMS1 PNO1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BYSL PNO1 25348397 N/A physical interaction ComPPI
UTP14C PNO1 25348397 N/A physical interaction ComPPI
RPS7 PNO1 25348397 N/A physical interaction ComPPI
NPM1 PNO1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RXRG PNO1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TRAF6 PNO1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
VCP PNO1 25348397 N/A physical interaction ComPPI
GSTP1 PNO1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RPS26 PNO1 25348397 N/A physical interaction ComPPI
EGLN3 PNO1 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
PICK1 PNO1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RPL10 PNO1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RB1 PNO1 25348397 N/A physical interaction ComPPI
PTPN2 PNO1 25348397 N/A physical interaction ComPPI
PDPK1 PNO1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CSNK1E PNO1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MYC PNO1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HNRNPU PNO1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XPO1 PNO1 25348397 N/A physical interaction ComPPI
RPS6 PNO1 25348397 N/A physical interaction ComPPI
RPS13 PNO1 25348397 N/A physical interaction ComPPI
EGFR PNO1 25348397 N/A physical interaction ComPPI
RNF2 PNO1 25348397 N/A physical interaction ComPPI
KLF6 PNO1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
EED PNO1 25348397 N/A physical interaction ComPPI
UTP14A PNO1 25348397 N/A physical interaction ComPPI
CAND1 PNO1 25348397 N/A physical interaction ComPPI
SUPT5H PNO1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FOXA1 PNO1 25348397 N/A physical interaction ComPPI
RPS9 PNO1 25348397 N/A physical interaction ComPPI
RPS20 PNO1 25348397 N/A physical interaction ComPPI
NOB1 PNO1 12628929 21075849 25348397 26186194 26344197 27898060 N/A physical interaction ComPPI,OmniPath
RPSA PNO1 25348397 N/A physical interaction ComPPI
IGFBP5 PNO1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ATP5F1C PNO1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HNRNPA1 PNO1 24234451 25348397 30021884 physical association cross-linking study,physical interaction ComPPI,IntAct
PNO1 SGSM2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PNO1 FRZB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PNO1 WDR3 25348397 N/A physical interaction ComPPI
PNO1 DDX49 25348397 N/A physical interaction ComPPI
PNO1 FBL 25348397 N/A physical interaction ComPPI
PNO1 FAU 25348397 N/A physical interaction ComPPI
PNO1 FAU 25348397 N/A physical interaction ComPPI
PNO1 KCMF1 25348397 N/A physical interaction ComPPI
PNO1 RPS12 25348397 N/A physical interaction ComPPI
PNO1 RPS23 25348397 N/A physical interaction ComPPI
PNO1 RPS24 25348397 N/A physical interaction ComPPI
PNO1 RPS5 25348397 N/A physical interaction ComPPI
PNO1 WDR26 25348397 N/A physical interaction ComPPI
PNO1 PYM1 25348397 N/A physical interaction ComPPI
PNO1 RPS3 25348397 N/A physical interaction ComPPI
PNO1 TSR1 25348397 N/A physical interaction ComPPI
PNO1 MTMR3 25348397 N/A physical interaction ComPPI
PNO1 LRRC47 25348397 N/A physical interaction ComPPI
PNO1 NOC3L 25348397 N/A physical interaction ComPPI
PNO1 NSUN2 25348397 N/A physical interaction ComPPI
PNO1 NCBP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PNO1 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
RPS15A PNO1 25348397 N/A physical interaction ComPPI
RPS27 PNO1 25348397 N/A physical interaction ComPPI
COMTD1 PNO1 25348397 N/A physical interaction ComPPI
HNRNPA2B1 PNO1 24234451 30021884 physical association cross-linking study IntAct
HNRNPA1L2 PNO1 24234451 30021884 physical association cross-linking study IntAct
EMC8 PNO1 25144938 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009BBDF8 PNO1 27087310 direct interaction,inhibition N/A NPInter

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