GENE：SLC11A1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SLC11A1 |
| FullNmae | solute carrier family 11 member 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:10907 |
| EnsembleID | ENSG00000018280 |
| Uniprot | P49279 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SLC11A1 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SLC11A1 | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SLC11A1 | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| SLC11A1 | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| SLC11A1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SLC11A1 | ferroptosis | 39959647 | Cell experiments confirmed that SLC11A1 was significantly upregulated in inflammatory microglia induced by ferroptosis. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SLC11A1 | GO:0001818,GO:0001819,GO:0002309,GO:0002606,GO:0002827,GO:0005381,GO:0005381,GO:0005384,GO:0005384,GO:0005384,GO:0005764,GO:0005765,GO:0005770,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0006826,GO:0006826,GO:0006828,GO:0006828,GO:0006879,GO:0006879,GO:0006909,GO:0006954,GO:0007035,GO:0009617,GO:0010628,GO:0015086,GO:0015707,GO:0019730,GO:0030001,GO:0030670,GO:0030670,GO:0031902,GO:0031902,GO:0032147,GO:0032496,GO:0032496,GO:0032729,GO:0034341,GO:0034755,GO:0042060,GO:0042116,GO:0042742,GO:0042803,GO:0042832,GO:0045342,GO:0045454,GO:0045730,GO:0045944,GO:0046915,GO:0048002,GO:0048255,GO:0050766,GO:0050829,GO:0051139,GO:0051139,GO:0051139,GO:0051139,GO:0051649,GO:0060586,GO:0070574,GO:0070821,GO:0070821,GO:0071421,GO:0098849,GO:0101003,GO:1902600,GO:1903826 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SLC11A1 | hsa:6556 | path:hsa04142 | Lysosome - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ELAVL1 | SLC11A1 | 16135804 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| EGR1 | SLC11A1 | 19032775 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| ATF3 | SLC11A1 | 21300803 23180781 | physical association | anti tag coimmunoprecipitation,pull down | InnateDB |
| JUNB | SLC11A1 | 21300803 23180781 | physical association | pull down | InnateDB |
| SMARCA4 | SLC11A1 | 21300803 23180781 | physical association | pull down | InnateDB |
| ACTB | SLC11A1 | 21300803 23180781 | physical association | pull down | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRDM14 | SLC11A1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SLC11A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SLC11A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SLC11A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SLC11A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | SLC11A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | SLC11A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SLC11A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SLC11A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETV4 | SLC11A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | SLC11A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | SLC11A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFAP2A | SLC11A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00002373FD | SLC11A1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000EF0B | SLC11A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CC379 | SLC11A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E226A | SLC11A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005F1B8C | SLC11A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003FD55 | SLC11A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |