GENE：TBC1D8
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TBC1D8 |
| FullNmae | TBC1 domain family member 8 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:17791 |
| EnsembleID | ENSG00000204634 |
| Uniprot | O95759 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TBC1D8 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TBC1D8 | GO:0005096,GO:0005515,GO:0008015,GO:0008284,GO:0016020,GO:0090630 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | TBC1D8 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | TBC1D8 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | TBC1D8 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TFAP2C | TBC1D8 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | TBC1D8 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | TBC1D8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | TBC1D8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TBC1D8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | TBC1D8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | TBC1D8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | TBC1D8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | TBC1D8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | TBC1D8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | TBC1D8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | TBC1D8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | TBC1D8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | TBC1D8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | TBC1D8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | TBC1D8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | TBC1D8 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00001BCAC5 | TBC1D8 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F4657 | TBC1D8 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006F90B | TBC1D8 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C85B2 | TBC1D8 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FC5B0 | TBC1D8 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B989F | TBC1D8 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A7F58 | TBC1D8 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SPP1 | TBC1D8 | 25348397 | N/A | physical interaction | ComPPI |
| TRAF1 | TBC1D8 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| TRAF4 | TBC1D8 | 12023963 14525934 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| TBC1D8 | THOC2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TBC1D8 | SCRIB | 24234451 30126976 | N/A | p8 filamentous phage display | IntAct |