GENE：TBXA2R
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TBXA2R |
| FullNmae | thromboxane A2 receptor |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11608 |
| EnsembleID | ENSG00000006638 |
| Uniprot | P21731 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TBXA2R | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TBXA2R | GO:0001669,GO:0004961,GO:0005085,GO:0005515,GO:0005886,GO:0005886,GO:0005886,GO:0006939,GO:0006954,GO:0007186,GO:0007189,GO:0007204,GO:0007584,GO:0009410,GO:0016607,GO:0019932,GO:0030194,GO:0033574,GO:0038193,GO:0045471,GO:0045766,GO:0045777,GO:0045907,GO:0045987,GO:0071222,GO:0090051 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TBXA2R | hsa:6915 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| TBXA2R | hsa:6915 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| TBXA2R | hsa:6915 | path:hsa04611 | Platelet activation - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TBXA2R | GRK5 | 11504827 23180781 | phosphorylation reaction | protein kinase assay | InnateDB |
| WT1 | TBXA2R | 23180781 24747176 | physical association | anti tag coimmunoprecipitation | InnateDB |
| HIC1 | TBXA2R | 23180781 24747176 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| EGR1 | TBXA2R | 18698092 18971253 19067769 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| ETS1 | TBXA2R | 18698092 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| GATA1 | TBXA2R | 18698092 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| GATA2 | TBXA2R | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| NFE2 | TBXA2R | 18698092 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| SP1 | TBXA2R | 18698092 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| WT1 | TBXA2R | 19067769 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| SMARCA4 | TBXA2R | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | TBXA2R | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TBXA2R | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | TBXA2R | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | TBXA2R | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | TBXA2R | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | TBXA2R | 18698092 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000001EB3 | TBXA2R | 24558106 25416803 | mrna cleavage,inhibition | array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000355E82 | TBXA2R | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075C1E1 | TBXA2R | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002A8BC6 | TBXA2R | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032AE90 | TBXA2R | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E5ECC | TBXA2R | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A760 | TBXA2R | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | TBXA2R | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000137EDE | TBXA2R | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000019907A | TBXA2R | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075B538 | TBXA2R | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004DA9DB | TBXA2R | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C770D | TBXA2R | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000160683 | TBXA2R | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006372A | TBXA2R | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C5969 | TBXA2R | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003FBC84 | TBXA2R | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005E6F45 | TBXA2R | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FF522 | TBXA2R | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AA845 | TBXA2R | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000116F83 | TBXA2R | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006B702 | TBXA2R | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C0FCB | TBXA2R | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BD6DC | TBXA2R | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000009EA8F | TBXA2R | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D814 | TBXA2R | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075CC78 | TBXA2R | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000ECE9C | TBXA2R | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004E02F2 | TBXA2R | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000004BACE | TBXA2R | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000001A7A | TBXA2R | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001012BC | TBXA2R | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000007FBA | TBXA2R | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075BDAA | TBXA2R | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021202F | TBXA2R | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CBC6D | TBXA2R | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AB14 | TBXA2R | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RACK1 | TBXA2R | 18088317 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| PRKCA | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| RHOA | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| PKN1 | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| PRKACA | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| PRKG1 | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| YWHAZ | TBXA2R | 14525934 16413928 25348397 | N/A | experimental interaction detection,physical interaction,two hybrid | ComPPI,HPRD |
| GNAQ | TBXA2R | 12193606 14525934 25348397 9152406 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| CANX | TBXA2R | 17644091 24234451 25348397 | colocalization | fluorescence microscopy | ComPPI,IntAct |
| PRDX4 | TBXA2R | 17644091 24234451 25348397 27898060 | physical association | anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction | ComPPI,IntAct,OmniPath |
| PTGIR | TBXA2R | 15471868 20522800 23493750 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| GNA13 | TBXA2R | 10395940 14525934 25348397 8290554 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| GRK6 | TBXA2R | 11504827 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| GRK5 | TBXA2R | 11504827 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| ARRB2 | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| RAB11A | TBXA2R | 14525934 15134434 16126723 20395296 25348397 27898060 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| SIVA1 | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| RAF1 | TBXA2R | 14525934 16413928 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| KCNMA1 | TBXA2R | 20959415 23255603 24234451 25348397 27898060 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescent resonance energy transfer,pull down,physical interaction | ComPPI,IntAct,OmniPath |
| GNG2 | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| GHRL | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| GPRASP1 | TBXA2R | 15086532 24234451 25348397 | N/A | pull down,physical interaction | ComPPI,IntAct |
| GNA11 | TBXA2R | 14525934 25348397 9152406 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| GNAS | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| PSME3 | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| PLCB2 | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| GNAI2 | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| PSMA7 | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| KCNMB1 | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| GNB1 | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| NME2 | TBXA2R | 14525934 14976202 25348397 27898060 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| AAMP | TBXA2R | 21172430 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| GNAS | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| GNAS | TBXA2R | 25348397 | N/A | physical interaction | ComPPI |
| GNA12 | TBXA2R | 14525934 25348397 8290554 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| TBXA2R | RPGRIP1L | 19464661 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| TBXA2R | WDR36 | 25348397 | N/A | physical interaction | ComPPI |
| TBXA2R | TBXA2R | 12551898 14525934 | N/A | experimental interaction detection | HPRD |
| PRKACA | TBXA2R | 12147288 14530262 27898060 | inhibition | N/A | OmniPath |
| PRKCA | TBXA2R | 10827090 11504827 12370102 15100160 17466390 24490858 27898060 | inhibition | N/A | OmniPath |
| GNAI2 | TBXA2R | 16212421 27898060 | N/A | N/A | OmniPath |
| GRK2 | TBXA2R | 16956790 27898060 | inhibition | N/A | OmniPath |
| GRK5 | TBXA2R | 11504827 27898060 | N/A | N/A | OmniPath |