Gene Information gene info

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GENE：VWF

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol VWF
FullNmae von Willebrand factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12726
EnsembleID ENSG00000110799
Uniprot P04275

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
VWF ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
VWF GO:0002020,GO:0002020,GO:0005178,GO:0005201,GO:0005515,GO:0005518,GO:0005576,GO:0005576,GO:0005576,GO:0005576,GO:0005615,GO:0005783,GO:0007155,GO:0007596,GO:0007596,GO:0007599,GO:0009611,GO:0019865,GO:0030168,GO:0030168,GO:0031012,GO:0031091,GO:0031093,GO:0031589,GO:0031589,GO:0033093,GO:0042802,GO:0051087,GO:0062023,GO:0062023,GO:0070062,GO:1902533

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
VWF hsa:7450 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
VWF hsa:7450 path:hsa04510 Focal adhesion - Homo sapiens (human)
VWF hsa:7450 path:hsa04512 ECM-receptor interaction - Homo sapiens (human)
VWF hsa:7450 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
VWF hsa:7450 path:hsa04611 Platelet activation - Homo sapiens (human)
VWF hsa:7450 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
VWF hsa:7450 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
VWF hsa:7450 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GZMB VWF 18577516 23180781 protein cleavage protease assay InnateDB
VWF ADAMTS13 18577516 23180781 protein cleavage protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR VWF 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 VWF 18971253 20019798 9444957 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
NFKB1 VWF 10361125 10848823 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
YBX1 VWF 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
POU2F1 VWF 7507210 9694713 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
FOXP3 VWF 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 VWF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA VWF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF VWF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 VWF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 VWF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 VWF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 VWF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS VWF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 VWF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A VWF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF VWF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 VWF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 VWF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 VWF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ERG VWF 19359602 22235125 9444957 trascriptional regulation,stimulation inferred by curator TFlink
KCNH2 VWF 19359602 22235125 9444957 trascriptional regulation,stimulation inferred by curator TFlink
ETS2 VWF 9444957 trascriptional regulation,stimulation inferred by curator TFlink
GATA6 VWF 12511565 trascriptional regulation,stimulation inferred by curator TFlink
NFIC VWF 11895773 trascriptional regulation,stimulation inferred by curator TFlink
NFIL3 VWF 15498853 trascriptional regulation,stimulation inferred by curator TFlink
RELA VWF 10848823 trascriptional regulation,stimulation inferred by curator TFlink
YY1 VWF 11522021 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
VWF ITGB3 25361965 interaction type N/A PTMCode2
ITGB3 VWF 25361965 interaction type N/A PTMCode2
VWF ITGA2B 25361965 interaction type N/A PTMCode2
ITGA2B VWF 25361965 interaction type N/A PTMCode2
VWF FURIN 25361965 interaction type N/A PTMCode2
FURIN VWF 25361965 interaction type N/A PTMCode2
VWF COL1A2 25361965 interaction type N/A PTMCode2
COL1A2 VWF 25361965 interaction type N/A PTMCode2
VWF GP1BA 25361965 interaction type N/A PTMCode2
GP1BA VWF 25361965 interaction type N/A PTMCode2
VWF F8 25361965 interaction type N/A PTMCode2
F8 VWF 25361965 interaction type N/A PTMCode2
VWF ADAMTS13 25361965 interaction type N/A PTMCode2
ADAMTS13 VWF 25361965 interaction type N/A PTMCode2
COL1A1 VWF 25361965 interaction type N/A PTMCode2
VWF COL1A1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
COL1A2 VWF 14525934 25348397 3490481 N/A experimental interaction detection,in vitro ComPPI,HPRD
ZNF512B VWF 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
OPTN VWF 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
RAC1 VWF 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ITGAV VWF 1694173 24234451 25348397 physical association solid phase assay ComPPI,IntAct
FURIN VWF 14525934 1571548 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
ITGA2B VWF 14525934 1737795 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CALR VWF 10887119 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
P4HB VWF 25348397 N/A physical interaction ComPPI
HSPA5 VWF 10887119 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HSP90B1 VWF 25348397 N/A physical interaction ComPPI
PDIA4 VWF 25348397 N/A physical interaction ComPPI
F8 VWF 14525934 18492805 24234451 25348397 3134349 9218428 N/A experimental interaction detection,physical interaction,enzyme linked immunosorbent assay,in vitro ComPPI,HPRD,IntAct
CACNA1A VWF 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VWF TNFRSF11B 14525934 15799029 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
VWF ADAMTS13 12775718 14525934 15824096 16221672 18492805 24234451 25348397 25512528 protein cleavage experimental interaction detection,surface plasmon resonance,physical interaction,protease assay,in vitro,bio-layer interferometry ComPPI,HPRD,IntAct
VWF COL1A1 14525934 25348397 3490481 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VWF HGF 25348397 N/A enzyme linked immunosorbent assay ComPPI
VWF GP1BA 12183630 15039442 24234451 25348397 N/A x-ray crystallography,physical interaction ComPPI,IntAct
VWF MAP3K3 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
VWF ATXN7 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VWF SOCS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VWF COL3A1 25348397 N/A physical interaction ComPPI
VWF VWF 12121649 14525934 17895385 18182488 18492805 21857647 24234451 9331419 9553097 covalent binding dynamic light scattering,electron microscopy,experimental interaction detection,light scattering,molecular sieving,comigration in non denaturing gel electrophoresis,comigration in gel electrophoresis,comigration in sds page HPRD,IntAct
CKAP4 VWF 24234451 30021884 physical association cross-linking study IntAct
H3-4 VWF 24234451 30021884 physical association cross-linking study IntAct
H4C1 VWF 24234451 30021884 physical association cross-linking study IntAct
FGG VWF 2243140 27898060 inhibition N/A OmniPath
VWF F8 18492805 23020315 27898060 3134349 9218428 stimulant N/A OmniPath
ADAMTS13 VWF 12775718 15824096 16221672 18492805 18577516 23020315 27898060 inhibition,stimulant N/A OmniPath

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