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GENE：CDKN1C

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CDKN1C
FullNmae cyclin dependent kinase inhibitor 1C
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1786
EnsembleID ENSG00000129757
Uniprot P49918

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CDKN1C mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDKN1C ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDKN1C autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CDKN1C GO:0000122,GO:0001501,GO:0001822,GO:0004860,GO:0004861,GO:0005515,GO:0005634,GO:0005737,GO:0007049,GO:0007096,GO:0030099,GO:0030325,GO:0030511,GO:0033673,GO:0035264,GO:0042326,GO:0042551,GO:0043010,GO:0044877,GO:0045736,GO:0045892,GO:0045893,GO:0045930,GO:0050680,GO:0055123,GO:0060065,GO:0060669,GO:0071514,GO:0140678,GO:1902746,GO:1904030

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CDKN1C hsa:1028 path:hsa04110 Cell cycle - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDKN1C MAPK8 12963725 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
CDKN1C MAPK10 12963725 23180781 physical association gst pull down InnateDB
EP300 CDKN1C 15286281 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDKN1C HES1 22705236 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
CDKN1C CDK4 20005715 interaction type N/A PSP
CDKN1C PCNA 20005715 interaction type N/A PSP
CDKN1C CCND1 20005715 interaction type N/A PSP
CDKN1C LIMK1 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
ETS1 CDKN1C 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
E2F4 CDKN1C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CDKN1C 20106982 trascriptional regulation,stimulation inferred by curator TFlink
HOXA10 CDKN1C 15749785 trascriptional regulation,stimulation inferred by curator TFlink
KLF4 CDKN1C 19544095 trascriptional regulation,stimulation inferred by curator TFlink
PROX1 CDKN1C 17069925 trascriptional regulation,stimulation inferred by curator TFlink
VHL CDKN1C 15824735 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000170CF4 CDKN1C N/A 18413744 18521080 19153141 20018759 21278784 \N rna interference,inhibition array technology,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000153377 CDKN1C 18413744 19153141 19589872 \N rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000C85B2 CDKN1C 19153141 \N rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001A7F58 CDKN1C 19544458 \N rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000170CF4 CDKN1C 18413744 18521080 19153141 20018759 21278784 21538272 22743998 25416803 26153983 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,chromatin immunoprecipitation assay,northern blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS0000153377 CDKN1C 18413744 19153141 19589872 23447020 25416803 26153983 mrna cleavage,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001A7F58 CDKN1C 19544458 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00000C85B2 CDKN1C 19153141 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 CDKN1C 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
AKT1 CDKN1C 22135298 phosphorylation N/A PhosphoSite
FBXL12 CDKN1C 25361965 interaction type N/A PTMCode2
CDKN1C FBXL12 25361965 interaction type N/A PTMCode2
CCNA2 CDKN1C 25361965 interaction type N/A PTMCode2
CDKN1C CCNA2 25361965 interaction type N/A PTMCode2
CDK4 CDKN1C 25361965 interaction type N/A PTMCode2
CDKN1C CDK4 25361965 interaction type N/A PTMCode2
CCND1 CDKN1C 25361965 interaction type N/A PTMCode2
CDKN1C CCND1 25361965 interaction type N/A PTMCode2
PCNA CDKN1C 25361965 interaction type N/A PTMCode2
CDKN1C PCNA 25361965 interaction type N/A PTMCode2
MYOD1 CDKN1C 25361965 interaction type N/A PTMCode2
CDKN1C MYOD1 25361965 interaction type N/A PTMCode2
SKP2 CDKN1C 25361965 interaction type N/A PTMCode2
CDKN1C SKP2 25361965 interaction type N/A PTMCode2
CCNE2 CDKN1C 25361965 interaction type N/A PTMCode2
CDKN1C CCNE2 25361965 interaction type N/A PTMCode2
CUL1 CDKN1C 25361965 interaction type N/A PTMCode2
CDKN1C CUL1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PCNA CDKN1C 14525934 22634751 24234451 25348397 27898060 9465025 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
CCND1 CDKN1C 25348397 N/A physical interaction ComPPI
CDK6 CDKN1C 25348397 N/A physical interaction ComPPI
MYOD1 CDKN1C 10764802 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RB1 CDKN1C 25348397 N/A physical interaction ComPPI
COPS5 CDKN1C 25348397 N/A physical interaction ComPPI
MYBL2 CDKN1C 25348397 N/A physical interaction ComPPI
CDKN1C LIMK1 14525934 14530263 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CDKN1C SKP2 12925736 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CDKN1C NR4A2 14525934 14671317 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CDKN1C CDK4 14525934 24234451 25348397 9106657 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CDKN1C CCNE2 14525934 24234451 25348397 9840943 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CDKN1C FBXL12 14525934 18660753 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CDKN1C CCNA2 25348397 N/A physical interaction ComPPI
CDKN1C RBL1 25348397 N/A physical interaction ComPPI
CDKN1C CDK2 23455922 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CDKN1C AKT1 25348397 N/A physical interaction ComPPI
CDKN1C CCND2 25348397 N/A physical interaction ComPPI
CDKN1C CCND3 25348397 N/A physical interaction ComPPI
CDKN1C CDK1 25348397 N/A physical interaction ComPPI
CDKN1C CDK3 25348397 N/A physical interaction ComPPI
CDKN1C TP53 25348397 N/A physical interaction ComPPI
CDKN1C MCM7 16289477 24234451 25348397 physical association two hybrid,pull down,two hybrid array ComPPI,IntAct
MAPK10 CDKN1C 12963725 27898060 N/A N/A OmniPath
GFI1 CDKN1C 18652815 27898060 stimulant N/A OmniPath
AKT1 CDKN1C 12925736 23421998 27898060 inhibition N/A OmniPath
MAPK14 CDKN1C 22820251 27898060 stimulant N/A OmniPath
KDM1A CDKN1C 15620353 27898060 inhibition N/A OmniPath
MAPK8 CDKN1C 12963725 27898060 N/A N/A OmniPath

Visualization










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