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GENE：RET

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RET
FullNmae ret proto-oncogene
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9967
EnsembleID ENSG00000165731
Uniprot P07949

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RET ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RET apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RET apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
RET GO:0000165,GO:0001657,GO:0001755,GO:0001838,GO:0004713,GO:0004714,GO:0004714,GO:0004714,GO:0005509,GO:0005515,GO:0005524,GO:0005769,GO:0005886,GO:0005886,GO:0006468,GO:0007156,GO:0007158,GO:0007165,GO:0007169,GO:0007275,GO:0007411,GO:0007497,GO:0009410,GO:0010008,GO:0010628,GO:0010976,GO:0014042,GO:0030155,GO:0030335,GO:0030424,GO:0030425,GO:0033141,GO:0033619,GO:0033630,GO:0033674,GO:0035799,GO:0035860,GO:0038023,GO:0042551,GO:0043025,GO:0043235,GO:0043235,GO:0043410,GO:0043410,GO:0045793,GO:0045893,GO:0048265,GO:0048484,GO:0050770,GO:0051897,GO:0060041,GO:0060384,GO:0061146,GO:0071300,GO:0072300,GO:0097021,GO:0098797,GO:2001241

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RET hsa:5979 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
RET hsa:5979 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
RET hsa:5979 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
RET hsa:5979 path:hsa05200 Pathways in cancer - Homo sapiens (human)
RET hsa:5979 path:hsa05216 Thyroid cancer - Homo sapiens (human)
RET hsa:5979 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
RET hsa:5979 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IKBKG RET 20098747 23180781 physical association protein array InnateDB
RET DOK6 15286081 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
GDNF RET 23331499 8674117 stimulation N/A SignaLink,SignaLink
RET GRB10 23331499 7665556 stimulation N/A SignaLink
RET STAT3 11536047 12637586 15485908 23331499 stimulation N/A SignaLink
RET DOK4 11470823 23331499 stimulation N/A SignaLink
RET DOK5 11470823 15286081 23331499 stimulation N/A SignaLink
RET GRAP 23331499 8183561 stimulation N/A SignaLink
RET SHC1 23331499 8183561 9047384 stimulation N/A SignaLink
RET GFRA1 10829012 23331499 stimulation N/A SignaLink
RET FRS2 11360177 11390647 23331499 stimulation N/A SignaLink
RET GRB7 23331499 8631863 stimulation N/A SignaLink
RET DOK1 12087092 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AKAP5 RET 20005715 interaction type N/A PSP
CRK RET 20005715 interaction type N/A PSP
DOK1 RET 12087092 16153436 18988627 20005715 21071413 interaction type N/A PSP,SignaLink
DOK2 RET 20005715 interaction type N/A PSP
DOK3 RET 20005715 interaction type N/A PSP
DOK4 RET 20005715 interaction type N/A PSP
DOK5 RET 11470823 18988627 20005715 21071413 interaction type N/A PSP,SignaLink
FRS2 RET 20005715 interaction type N/A PSP
GAB1 RET 11360177 18988627 20005715 interaction type N/A PSP,SignaLink
GRB10 RET 20005715 interaction type N/A PSP
GRB2 RET 20005715 interaction type N/A PSP
GRB7 RET 18988627 20005715 21071413 8631863 interaction type N/A PSP,SignaLink
PIK3R1 RET 20005715 interaction type N/A PSP
PRKAR2A RET 20005715 interaction type N/A PSP
SHC1 RET 20005715 interaction type N/A PSP
SHC3 RET 20005715 interaction type N/A PSP
GRB2 RET 20005715 N/A N/A SignaLink
CRK RET 20005715 20005715 N/A N/A SignaLink
DOK2 RET 11470823 18988627 20005715 20005715 N/A N/A SignaLink
DOK4 RET 11470823 18988627 20005715 20005715 N/A N/A SignaLink
FRS2 RET 11360177 18988627 20005715 20005715 N/A N/A SignaLink
GRB10 RET 18988627 20005715 20005715 21071413 7665556 7665556 N/A N/A SignaLink
PIK3R1 RET 10652352 18988627 20005715 20005715 N/A N/A SignaLink
SHC1 RET 18988627 20005715 20005715 8183561 9047384 N/A N/A SignaLink
SHC3 RET 12242309 18988627 20005715 20005715 N/A N/A SignaLink
AKAP5 RET 20005715 20005715 N/A N/A SignaLink
DOK3 RET 11470823 18988627 20005715 20005715 N/A N/A SignaLink
PRKAR2A RET 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ESR1 RET 21737465 21878914 21947652 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 RET 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 RET 18971253 21878914 21947652 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 RET 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C RET 20629094 22878616 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 RET 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 RET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 RET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 RET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 RET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 RET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 RET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NKX2-1 RET 19853745 trascriptional regulation,stimulation inferred by curator TFlink
SOX10 RET 14523991 20977903 trascriptional regulation,stimulation inferred by curator TFlink
SP3 RET N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000001EB3 RET 19524507 rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000001EB3 RET 19524507 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000076995 RET 21169019 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS00000F31F4 RET 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 RET 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000040EE1D RET 23022987 25416803 mrna cleavage,inhibition experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS0000171CD1 RET 23022987 25416803 mrna cleavage,inhibition experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS0000330617 RET 23022987 25416803 mrna cleavage,inhibition experimental interaction detection,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA RET 22135298 phosphorylation N/A PhosphoSite
SRC RET 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PTK2 RET 22135298 phosphorylation N/A PhosphoSite
PRKCA RET 22135298 phosphorylation N/A PhosphoSite
RET PIK3R1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
RET RET 22135298 phosphorylation N/A PhosphoSite
RET PDPK1 22135298 phosphorylation N/A PhosphoSite
RET ATF4 22135298 phosphorylation N/A PhosphoSite
RET DOK1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
RET PTK2 22135298 phosphorylation N/A PhosphoSite
RET PLCG1 22135298 phosphorylation N/A PhosphoSite
RET AFAP1L2 22135298 phosphorylation N/A PhosphoSite
RET MAPK9 22135298 phosphorylation N/A PhosphoSite
RET AKT1 22135298 phosphorylation N/A PhosphoSite
RET MAPK1 22135298 phosphorylation N/A PhosphoSite
RET MAPK8 22135298 phosphorylation N/A PhosphoSite
RET MAPK3 22135298 phosphorylation N/A PhosphoSite
RET MAPK14 22135298 phosphorylation N/A PhosphoSite
STAT3 RET 25361965 interaction type N/A PTMCode2
RET STAT3 25361965 interaction type N/A PTMCode2
CBLB RET 25361965 interaction type N/A PTMCode2
RET CBLB 25361965 interaction type N/A PTMCode2
DOK4 RET 25361965 interaction type N/A PTMCode2
RET DOK4 25361965 interaction type N/A PTMCode2
CBL RET 25361965 interaction type N/A PTMCode2
RET CBL 25361965 interaction type N/A PTMCode2
DOK5 RET 25361965 interaction type N/A PTMCode2
RET DOK5 25361965 interaction type N/A PTMCode2
SHC2 RET 25361965 interaction type N/A PTMCode2
RET SHC2 25361965 interaction type N/A PTMCode2
GAB1 RET 25361965 interaction type N/A PTMCode2
RET GAB1 25361965 interaction type N/A PTMCode2
GRB2 RET 25361965 interaction type N/A PTMCode2
RET GRB2 25361965 interaction type N/A PTMCode2
CRK RET 25361965 interaction type N/A PTMCode2
RET CRK 25361965 interaction type N/A PTMCode2
DOK2 RET 25361965 interaction type N/A PTMCode2
RET DOK2 25361965 interaction type N/A PTMCode2
FRS2 RET 25361965 interaction type N/A PTMCode2
RET FRS2 25361965 interaction type N/A PTMCode2
PIK3R1 RET 25361965 interaction type N/A PTMCode2
RET SRC 25361965 interaction type N/A PTMCode2
RET SHC3 25361965 interaction type N/A PTMCode2
SHC3 RET 25361965 interaction type N/A PTMCode2
RET DOK6 25361965 interaction type N/A PTMCode2
DOK6 RET 25361965 interaction type N/A PTMCode2
RET GRB10 25361965 interaction type N/A PTMCode2
GRB10 RET 25361965 interaction type N/A PTMCode2
RET SOS1 25361965 interaction type N/A PTMCode2
SOS1 RET 25361965 interaction type N/A PTMCode2
RET SHC1 25361965 interaction type N/A PTMCode2
SHC1 RET 25361965 interaction type N/A PTMCode2
DOK1 RET 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TXNL4A RET 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SGTB RET 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ZBTB48 RET 25348397 N/A physical interaction ComPPI
CRK RET 10208419 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
CTNND1 RET 21357690 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DOK6 RET 14525934 15286081 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GRB7 RET 14525934 25348397 8631863 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CBL RET 12727845 14525934 15677445 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
MAPK1 RET 14525934 16153436 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
CBLB RET 14525934 16525057 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAPK8 RET 14525934 16153436 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PIK3R1 RET 10652352 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PTPN11 RET 12959980 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SRC RET 10070972 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GRB10 RET 14525934 25348397 7665556 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
DOK1 RET 12087092 14525934 16153436 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SHC1 RET 14525934 15677445 24234451 25348397 8183561 9047384 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SOS1 RET 19914172 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CASP3 RET 25348397 N/A protease assay ComPPI
MAPK3 RET 14525934 16153436 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
CBLC RET 25348397 N/A physical interaction ComPPI
GRB2 RET 14525934 15677445 24234451 25348397 9393871 physical association experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
DOK3 RET 11470823 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
MAPK14 RET 14525934 16153436 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
FRS2 RET 11360177 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
AIP RET 19366855 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GAB1 RET 11360177 14525934 19914172 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
HSP90AA1 RET 25348397 N/A physical interaction ComPPI
NTRK1 RET 25348397 N/A physical interaction ComPPI
PTPRF RET 25348397 N/A physical interaction ComPPI
BAG6 RET 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAR2A RET 11886862 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PTPRR RET 25348397 N/A physical interaction ComPPI
PDLIM7 RET 12176011 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PKM RET 25348397 N/A protein kinase assay ComPPI
RET STAT3 11536047 12637586 14525934 15485908 24234451 25241761 25348397 association,physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
RET GDNF 14525934 25348397 8674117 N/A experimental interaction detection,in vitro ComPPI,HPRD
RET SHC3 12242309 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RET GFRA1 10774729 14525934 25348397 N/A experimental interaction detection,physical interaction,enzyme linked immunosorbent assay,in vivo ComPPI,HPRD
RET NRTN 14525934 25348397 9192898 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RET DOK2 11470823 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
RET DOK4 11470823 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
RET DOK5 11470823 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
RET PLCG1 14525934 16153436 24234451 25241761 25348397 8628282 association,physical association experimental interaction detection,physical interaction,competition binding,proximity ligation assay ComPPI,HPRD,IntAct
RET IKBKG 20098747 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
RET MCRS1 25348397 N/A physical interaction ComPPI
RET HSP90AA2P 25348397 N/A physical interaction ComPPI
RET NOTCH2NLA 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RET NOTCH3 25348397 N/A physical interaction ComPPI
RET EGFR 24234451 24658140 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
RET HNRNPD 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RET SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RET SYNCRIP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RET KYNU 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RET ZCCHC8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RET ICE2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RET PTK2 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
RET DUSP26 25348397 N/A physical interaction ComPPI
RET FAU 15677445 24234451 25348397 covalent binding anti bait coimmunoprecipitation ComPPI,IntAct
RET LRRK1 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
RET GAS1 24234451 25348397 25888394 N/A surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
H3C1 RET 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RET AKAP5 11886862 14525934 N/A experimental interaction detection HPRD
RET RET 10445857 11121408 14525934 14711813 15588985 20473317 24234451 8621380 N/A experimental interaction detection,x-ray crystallography HPRD,IntAct
RET PLCG1 16153436 16497976 1689310 17016520 17389395 20068231 25241761 27898060 7682059 8628282 8657103 8885868 N/A N/A OmniPath
PRKACA RET 20682772 27898060 inhibition,stimulant N/A OmniPath
PRKCA RET 22128160 27898060 N/A N/A OmniPath
PTPRF RET 11121408 27898060 inhibition N/A OmniPath
RET PDPK1 12738763 27898060 N/A N/A OmniPath
RET AKT1 15994200 27898060 stimulant N/A OmniPath
IKBKG RET 20098747 27898060 N/A N/A OmniPath
RET PTK2 12387730 15561106 15951569 16153436 17016520 17192257 17389395 18083107 19339212 19369195 19534553 19664994 20068231 21454698 25241761 27898060 7529876 9507031 stimulant N/A OmniPath
PTK2 RET 16153436 21454698 25241761 27898060 stimulant N/A OmniPath
RET MAPK3 16153436 25241761 27898060 stimulant N/A OmniPath
RET MAPK14 16153436 16497976 17016520 17126298 17548358 18088087 18452278 18669648 18691976 19651622 19682241 19901323 20068231 27898060 7535770 8622669 stimulant N/A OmniPath
RET SHC1 15677445 16189514 27898060 8183561 9047383 9047384 stimulant N/A OmniPath
RET PIK3R1 10652352 16153436 27898060 N/A N/A OmniPath
RET GRB10 27898060 7665556 8631863 stimulant N/A OmniPath
RET GRB7 27898060 8631863 stimulant N/A OmniPath
RET MAPK1 16153436 16497976 17016520 17389395 18452278 18578522 18669648 18691976 18707149 19415658 19651622 19901323 20068231 25241761 27898060 stimulant N/A OmniPath
RET STAT3 11536047 12637586 15485908 25241761 27898060 stimulant N/A OmniPath
RET MAPK8 16153436 18669648 27898060 stimulant N/A OmniPath
RET ATF4 25795775 27898060 N/A N/A OmniPath
RET FRS2 11360177 1136018 11390647 27898060 stimulant N/A OmniPath
RET GRAP 27898060 8183561 stimulant N/A OmniPath
RET DOK1 11551902 12087092 16153436 16497976 19901323 27898060 stimulant N/A OmniPath
GDNF RET 27898060 8674117 9182803 stimulant N/A OmniPath
RET GFRA4 11116144 27898060 N/A N/A OmniPath
NRTN RET 27898060 9182803 9192898 stimulant N/A OmniPath
RET DOK5 11470823 15286081 27898060 stimulant N/A OmniPath
RET GFRA1 10774729 10829012 11106404 14514671 27898060 9192898 stimulant N/A OmniPath
RET DOK6 15286081 27898060 stimulant N/A OmniPath
RET DOK4 11470823 27898060 stimulant N/A OmniPath
RET GFRA2 27898060 9182803 9192898 N/A N/A OmniPath
RET GFRA3 27898060 9883723 N/A N/A OmniPath
PTPRJ RET 16778204 27898060 inhibition N/A OmniPath

Visualization










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