Gene Information gene info

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GENE：XRCC2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol XRCC2
FullNmae X-ray repair cross complementing 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12829
EnsembleID ENSG00000196584
Uniprot O43543

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
XRCC2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
XRCC2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
XRCC2 GO:0000278,GO:0000400,GO:0000400,GO:0000724,GO:0000724,GO:0001701,GO:0001756,GO:0005515,GO:0005524,GO:0005654,GO:0005654,GO:0005657,GO:0005657,GO:0005737,GO:0005813,GO:0005813,GO:0006281,GO:0007098,GO:0010165,GO:0010332,GO:0022008,GO:0033063,GO:0033063,GO:0035264,GO:0042148,GO:0042148,GO:0043231,GO:0043524,GO:0050769,GO:0051321,GO:0140664,GO:2000269

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
XRCC2 hsa:7516 path:hsa03440 Homologous recombination - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BARD1 XRCC2 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773 26192618 interaction type N/A ACSN
BRCA1 XRCC2 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773 26192618 interaction type N/A ACSN
BRCA2 XRCC2 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773 26192618 interaction type N/A ACSN
FANCD2 XRCC2 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773 26192618 interaction type N/A ACSN
RAD51 XRCC2 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773 26192618 interaction type N/A ACSN
RAD52 XRCC2 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773 26192618 interaction type N/A ACSN
XRCC3 XRCC2 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
E2F4 XRCC2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 XRCC2 18414489 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation array,chromatin immunoprecipitation assay TFlink
ETS1 XRCC2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 XRCC2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 XRCC2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 XRCC2 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYCN XRCC2 16093321 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 XRCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA XRCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF XRCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 XRCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A XRCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 XRCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 XRCC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 XRCC2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000075D814 XRCC2 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 XRCC2 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F XRCC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005CCD18 XRCC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000486E0B XRCC2 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC XRCC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA XRCC2 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021202F XRCC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004977C5 XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CEB74 XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001B12A4 XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001AFC71 XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000183BED XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC864 XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000011DF XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000254A6 XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041E780 XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000277201 XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000023F8DA XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E XRCC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C XRCC2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000572E11 XRCC2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000028D811 XRCC2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000005A8ED XRCC2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 XRCC2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 XRCC2 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
XRCC2 MEOX2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
XRCC2 RAD51D 10749867 10871607 11751635 11842113 12975363 14525934 14704354 16710300 24234451 25348397 25416956 25910212 colocalization,association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,electron microscopy,experimental interaction detection,far western blotting,molecular sieving,pull down,physical interaction,two hybrid array,biochemical,in vitro,in vivo,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
XRCC2 BLM 12975363 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC2 RAD51 25348397 N/A physical interaction ComPPI
XRCC2 RAD51B 11751635 24234451 25348397 physical association molecular sieving,physical interaction,electrophoretic mobility-based method ComPPI,IntAct
XRCC2 RAD51C 11842113 24141787 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
XRCC2 NKIRAS1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
XRCC2 WFDC1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
XRCC2 NDUFAF5 25348397 N/A physical interaction ComPPI
XRCC2 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC2 MRPL50 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC2 ARL4C 25348397 N/A physical interaction ComPPI
XRCC2 DKKL1 25348397 N/A physical interaction ComPPI
XRCC2 HELQ 24005329 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC2 SPTA1 25348397 N/A physical interaction ComPPI
XRCC2 HNRNPL 25348397 N/A physical interaction ComPPI

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