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GENE：SMAD3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SMAD3
FullNmae SMAD family member 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6769
EnsembleID ENSG00000166949
Uniprot P84022

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SMAD3 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SMAD3 ferroptosis 37926174 SMAD3 could inhibit the LPS-induced polarization of M1 phenotype and ferroptosis in macrophages by targeting GPX4. retulator signature
SMAD3 apoptosis 37423522 Blunting Smad2 or Smad3 both strikingly induced human chondrocytes apoptosis, implying a plausible signaling pathway to clarify the mechanism of T-2 toxin-induced oxidative damage. retulator signature
SMAD3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SMAD3 GO:0000122,GO:0000122,GO:0000785,GO:0000785,GO:0000976,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0000987,GO:0000987,GO:0000987,GO:0001217,GO:0001222,GO:0001223,GO:0001228,GO:0001228,GO:0001228,GO:0001657,GO:0001666,GO:0001701,GO:0001707,GO:0001756,GO:0001889,GO:0001947,GO:0002076,GO:0002520,GO:0003677,GO:0003700,GO:0003700,GO:0005160,GO:0005515,GO:0005518,GO:0005634,GO:0005634,GO:0005637,GO:0005654,GO:0005654,GO:0005667,GO:0005667,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0005886,GO:0006355,GO:0006357,GO:0006919,GO:0006955,GO:0007179,GO:0007179,GO:0007254,GO:0007492,GO:0008013,GO:0008270,GO:0008285,GO:0009653,GO:0009880,GO:0010628,GO:0010629,GO:0010718,GO:0010718,GO:0016202,GO:0016922,GO:0017015,GO:0017151,GO:0019901,GO:0019902,GO:0023019,GO:0030154,GO:0030308,GO:0030325,GO:0030335,GO:0030501,GO:0030878,GO:0031053,GO:0031490,GO:0031625,GO:0031962,GO:0032332,GO:0032731,GO:0032810,GO:0032909,GO:0032916,GO:0032924,GO:0032924,GO:0033689,GO:0035259,GO:0038092,GO:0042060,GO:0042110,GO:0042177,GO:0042307,GO:0042802,GO:0042803,GO:0043066,GO:0043130,GO:0043235,GO:0043425,GO:0043565,GO:0045216,GO:0045429,GO:0045599,GO:0045668,GO:0045893,GO:0045944,GO:0045944,GO:0045944,GO:0048340,GO:0048589,GO:0048617,GO:0048701,GO:0050678,GO:0050728,GO:0050776,GO:0050821,GO:0050927,GO:0051091,GO:0051481,GO:0051496,GO:0051894,GO:0060039,GO:0060290,GO:0060395,GO:0060395,GO:0060395,GO:0061045,GO:0061629,GO:0061767,GO:0070306,GO:0070410,GO:0070411,GO:0070412,GO:0071141,GO:0071144,GO:0071144,GO:0071560,GO:0090263,GO:0097191,GO:0098586,GO:0140297,GO:1901203,GO:1902893,GO:1902894,GO:1902895,GO:1902895,GO:1903243,GO:1990841

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SMAD3 hsa:4088 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa04110 Cell cycle - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa04144 Endocytosis - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa04218 Cellular senescence - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa04520 Adherens junction - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa05161 Hepatitis B - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa05200 Pathways in cancer - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa05210 Colorectal cancer - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa05226 Gastric cancer - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
SMAD3 hsa:4088 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMAD3 SMAD7 11279127 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21614932 22331441 23784029 26192618 8515656 association N/A ACSN
SMAD4 SMAD3 10092624 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11486006 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17591701 17689680 17705132 18353785 18729074 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23180781 23338822 23390297 23784029 23869868 25374926 26192618 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020 association,physical association anti tag coimmunoprecipitation,gst pull down,electrophoretic mobility supershift assay,tandem affinity purification ACSN,InnateDB
SMAD3 SNAI1 11074002 11279127 11792802 12702545 12809600 15265520 16179589 16713975 17018611 17563753 18768831 19597490 21041997 21042762 21577210 21614932 22331441 22514743 26192618 8515656 9389648 interaction type N/A ACSN
SMAD3 SMAD2 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 26192618 8515656 9312026 9389648 9618481 9670020 9865696 association N/A ACSN
SMAD3 SP1 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 26192618 8515656 9312026 9389648 9618481 9670020 interaction type N/A ACSN
SMAD3 ACTA2 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD3 FAP 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
TGFBR1 SMAD3 11274345 12957874 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 23331499 24132110 24336330 26192618 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
TGFBR2 SMAD3 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330 26192618 interaction type N/A ACSN
SMAD3 TIMP1 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD3 TNC 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD3 ITGB5 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD3 SPP1 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 26192618 8515656 9312026 9389648 9618481 9670020 interaction type N/A ACSN
SMAD3 ETS1 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD3 ITGA11 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD3 FGF2 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD3 GLI1 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD3 GLI2 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD3 POSTN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD3 ZEB1 11074002 11279127 11792802 12702545 12809600 14976548 15265520 16179589 16713975 16831886 18768831 18832382 19208835 19597490 20731704 21042762 21317430 21614932 22331441 26192618 8515656 8893010 9389648 interaction type N/A ACSN
TGFB1 SMAD3 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 26192618 7594497 9311995 9865696 interaction type N/A ACSN
CDK2 SMAD3 10197981 11283614 12193595 14536078 15147722 15241418 15279786 16156666 17055429 17303408 17660363 18590585 18636226 20027199 20713526 2191300 26192618 28536364 7575488 interaction type N/A ACSN
CDK4 SMAD3 10197981 12193595 15241418 16156666 26192618 interaction type N/A ACSN
IL18 SMAD3 10679398 11592085 14504095 14662834 15099563 15802534 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IL15 SMAD3 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 26192618 7523571 interaction type N/A ACSN
SMAD3 NOS2 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 26192618 6357187 8515656 8871614 9389648 interaction type N/A ACSN
SMAD3 IFNG 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 26192618 6357187 8515656 8871614 9389648 interaction type N/A ACSN
SMAD3 IRF3 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 26192618 6357187 8515656 8871614 9389648 interaction type N/A ACSN
SMAD3 TBX21 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 26192618 6357187 8515656 8871614 9389648 interaction type N/A ACSN
SMAD3 SQSTM1 15761153 21988832 23180781 physical association anti tag coimmunoprecipitation,luminescence based mammalian interactome mapping InnateDB
SMAD3 ATF2 10085140 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
SMAD3 ERBIN 17591701 18729074 23180781 physical association anti tag coimmunoprecipitation,gst pull down,tandem affinity purification InnateDB
SMAD3 WWP1 15946939 23180781 physical association anti tag coimmunoprecipitation InnateDB
HIF1A SMAD3 11486006 12228247 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
SMAD3 VEGFA 11486006 18952601 23180781 physical association anti tag coimmunoprecipitation,pull down,electrophoretic mobility shift assay InnateDB
IRF7 SMAD3 14729983 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,two hybrid,pull down InnateDB
SMAD3 PIN1 19920136 23180781 physical association pull down InnateDB
SMAD3 COL1A1 19558215 23180781 physical association nucleic acid uv cross-linking assay InnateDB
SMAD3 NOTCH4 16007227 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 SKI 10549282 12764135 19032343 19049980 23180781 physical association anti tag coimmunoprecipitation,pull down,tandem affinity purification InnateDB
SMAD3 SKIL 12764135 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 SERPINE1 10092624 21625455 23180781 9606191 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay,electrophoretic mobility shift assay InnateDB
SMAD3 SMAD3 10092624 11331591 18729074 23180781 26467481 9843571 bind,physical association,up-regulates activity,down-regulates activity anti tag coimmunoprecipitation,tandem affinity purification InnateDB,Signor
SMAD3 S100A4 20070253 23180781 physical association anti tag coimmunoprecipitation,pull down,surface plasmon resonance InnateDB
SMAD3 PRDM16 19049980 20661427 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 HDAC1 19049980 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 FHL1 19139564 23180781 physical association pull down InnateDB
SMAD3 FHL2 19139564 23180781 physical association pull down InnateDB
SMAD3 FHL3 19139564 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
CREBBP SMAD3 15467747 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 SH2D2A 16806069 23180781 physical association pull down InnateDB
SMAD3 ELAC2 16636667 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 KLF5 19419955 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 DOCK9 18729074 23180781 physical association anti tag coimmunoprecipitation,tandem affinity purification InnateDB
SMAD2 SMAD3 18729074 23180781 physical association tandem affinity purification InnateDB
MAPK1 SMAD3 10197981 16156666 18729074 18988627 23180781 23331499 stimulation,physical association tandem affinity purification InnateDB,SignaLink,SignaLink
SMAD3 SMURF2 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 YY1 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 CSNK1D 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 LEMD3 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 WWP2 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 PJA1 18729074 23180781 physical association tandem affinity purification InnateDB
RPL3 SMAD3 18729074 23180781 physical association tandem affinity purification InnateDB
RPL4 SMAD3 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 DHX8 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 SLC25A12 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 FAM83G 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 DNAJA2 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 OPA1 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 EPB41L5 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 IRS1 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 SIK3 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 BUB3 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 SMAD1 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 SMAD5 18729074 23180781 physical association tandem affinity purification InnateDB
PSPC1 SMAD3 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 RAB11FIP5 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 SARG 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 ATXN2L 18729074 23180781 physical association tandem affinity purification InnateDB
CHD8 SMAD3 18729074 23180781 physical association tandem affinity purification InnateDB
SLC9A3R2 SMAD3 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 PABPC1 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 YTHDF2 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 LRCH1 18729074 23180781 physical association tandem affinity purification InnateDB
PTPN6 SMAD3 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 ITGB4 18729074 23180781 physical association tandem affinity purification InnateDB
DYRK1A SMAD3 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 U2AF2 18729074 23180781 physical association tandem affinity purification InnateDB
SQOR SMAD3 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 TCP1 18729074 23180781 physical association tandem affinity purification InnateDB
USP7 SMAD3 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 DCAF7 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 VAV2 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 IL37 20935647 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 EGR1 19374776 20690147 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 FLI1 20211142 23180781 physical association pull down InnateDB
SMAD7 SMAD3 21071413 21625455 23180781 23331499 9892009 9892110 stimulation,physical association anti tag coimmunoprecipitation InnateDB,SignaLink,SignaLink
SMAD3 STK17B 23122956 23180781 physical association anti tag coimmunoprecipitation InnateDB
SOX11 SMAD3 23180781 24681958 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 NOX4 23180781 24560583 physical association anti tag coimmunoprecipitation InnateDB
MYD88 SMAD3 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
CHRD SMAD3 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
SETD2 SMAD3 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
PPP1R12C SMAD3 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
RNF31 SMAD3 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 ZC3H12A 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 TSC22D4 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP SMAD3 21832049 23180781 physical association protein array InnateDB
TLE5 SMAD3 23180781 25416956 physical association two hybrid InnateDB
MECOM SMAD3 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 ESR1 11555647 23331499 stimulation N/A SignaLink,SignaLink
ESR1 SMAD3 11555647 18988627 20207742 21071413 23331499 interaction type N/A SignaLink,SignaLink
SMAD3 NOTCH1 14638857 18988627 23331499 stimulation N/A SignaLink,SignaLink
NOTCH1 SMAD3 14638857 21071413 23331499 interaction type N/A SignaLink,SignaLink
SMAD6 SMAD3 23331499 9892110 stimulation N/A SignaLink,SignaLink
MAPK3 SMAD3 10197981 23331499 stimulation N/A SignaLink,SignaLink
SMAD3 LEF1 10890911 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
FBXW11 SMAD3 11359933 23331499 stimulation N/A SignaLink,SignaLink
AXIN1 SMAD3 11438668 18988627 23331499 stimulation N/A SignaLink,SignaLink
MYC SMAD3 11804592 23331499 stimulation N/A SignaLink,SignaLink
SKIL SMAD3 10531062 11306568 11691834 12426322 12793438 21071413 23331499 stimulation N/A SignaLink,SignaLink
SKI SMAD3 10575014 11306568 12426322 12732634 12793438 12857746 12874272 17283070 21071413 23331499 stimulation N/A SignaLink,SignaLink
SMAD3 SMAD4 10531362 10878024 10995777 12794086 12957874 15231748 15350224 18988627 19135894 21071413 21532621 22045334 23331499 9311995 stimulation N/A SignaLink,SignaLink
SMAD3 MEF2C 15044954 23331499 stimulation N/A SignaLink,SignaLink
AKT1 SMAD3 15048128 16362038 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
PML SMAD3 15356634 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
PPM1A SMAD3 16751101 18988627 23331499 stimulation N/A SignaLink,SignaLink
CREB1 SMAD3 16862174 23331499 stimulation N/A SignaLink,SignaLink
GSK3B SMAD3 18172167 21071413 23331499 stimulation N/A SignaLink,SignaLink
PPP2CA SMAD3 20704570 23331499 stimulation N/A SignaLink,SignaLink
MTMR4 SMAD3 20704570 23331499 stimulation N/A SignaLink,SignaLink
ACVR1B SMAD3 23331499 9605406 stimulation N/A SignaLink
ACVR1C SMAD3 23331499 9920806 stimulation N/A SignaLink
SMAD3 JUN 10220381 23331499 9732876 stimulation N/A SignaLink
SMURF1 SMAD3 10458166 15221015 23331499 stimulation N/A SignaLink
KAT2A SMAD3 11058129 15009097 23331499 stimulation N/A SignaLink
SMAD3 AR 11248024 11280774 11707452 12226080 23331499 stimulation N/A SignaLink
SMAD3 GATA3 11790301 23331499 stimulation N/A SignaLink
EIF4E SMAD3 12150994 23331499 stimulation N/A SignaLink
SMAD3 MAX 12551947 23331499 stimulation N/A SignaLink
NR3C1 SMAD3 12902338 23331499 stimulation N/A SignaLink
PIAS4 SMAD3 12904571 23331499 stimulation N/A SignaLink
NUP214 SMAD3 12917407 23331499 stimulation N/A SignaLink
NUP153 SMAD3 12917407 23331499 stimulation N/A SignaLink
MAPK14 SMAD3 14512875 23331499 stimulation N/A SignaLink
PIAS3 SMAD3 14691252 23331499 stimulation N/A SignaLink
TRIM33 SMAD3 16751102 18003620 23331499 stimulation N/A SignaLink
RNF111 SMAD3 14657019 17341133 18950738 23331499 stimulation N/A SignaLink
SMAD3 STAT3 11257503 23331499 stimulation N/A SignaLink
EP300 SMAD3 10497242 10575014 11058129 15133024 20564330 21269274 23331499 9679056 stimulation N/A SignaLink
RANBP3 SMAD3 20704570 23331499 stimulation N/A SignaLink
ERBIN SMAD3 12650946 17591701 18003620 23331499 stimulation N/A SignaLink
DVL1 SMAD3 12650946 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR SMAD3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 SMAD3 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 SMAD3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 SMAD3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SMAD3 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 SMAD3 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 SMAD3 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 SMAD3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
RARA SMAD3 21310893 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C SMAD3 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SMAD3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 SMAD3 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SMAD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SMAD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SMAD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SMAD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SMAD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SMAD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SMAD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SMAD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 SMAD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SMAD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SMAD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 SMAD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SMAD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ARID1A SMAD3 21900401 trascriptional regulation,stimulation inferred by curator TFlink
TP53 SMAD3 21900401 trascriptional regulation,stimulation inferred by curator TFlink
TRIB3 SMAD3 21896644 trascriptional regulation,stimulation inferred by curator TFlink
WT1 SMAD3 20842112 trascriptional regulation,stimulation inferred by curator TFlink
WWTR1 SMAD3 22470139 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB SMAD3 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYC SMAD3 N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARG SMAD3 N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 SMAD3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 SMAD3 21036908 rna interference,inhibition western blot miRSponge
URS000035CC3E SMAD3 23249750 rna interference,inhibition western blot miRSponge
URS000008DA94 SMAD3 22020340 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000008DA94 SMAD3 22020340 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000035CC3E SMAD3 22291592 23249750 25416803 mrna cleavage,inhibition western blot,clip TarBase
URS0000237AF9 SMAD3 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000338542 SMAD3 21036908 25416803 mrna cleavage,inhibition western blot TarBase
URS00000AA464 SMAD3 23622248 24496888 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clash,miRNA interference luciferase reporter assay TarBase
URS00002075FA SMAD3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000008A99 SMAD3 22942087 25416803 mrna cleavage,inhibition array technology TarBase
URS00004F4657 SMAD3 22942087 23632450 24873879 25416803 25704091 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004F24A9 SMAD3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 SMAD3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C SMAD3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D SMAD3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A SMAD3 25416803 27063509 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS00001E0AEA SMAD3 25416803 26572508 27683030 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001919B0 SMAD3 25196641 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001A7F58 SMAD3 23892108 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000018E72A SMAD3 25416803 26908446 27059796 mrna cleavage,inhibition western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000019D79B SMAD3 25416803 26932538 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000272039 SMAD3 25416803 27054113 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00001CC864 SMAD3 25416803 27318087 27601936 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000183BED SMAD3 25416803 26153982 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00000F0F49 SMAD3 25416803 27655675 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001123BD SMAD3 25416803 27273381 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
MAPK1 SMAD3 22135298 phosphorylation N/A PhosphoSite
CDK4 SMAD3 22135298 phosphorylation N/A PhosphoSite
CDK9 SMAD3 22135298 phosphorylation N/A PhosphoSite
CDK8 SMAD3 22135298 phosphorylation N/A PhosphoSite
AKT1 SMAD3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
TEKT4 SMAD3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIN1 SMAD3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HNRNPK SMAD3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RBPMS SMAD3 25348397 N/A barcode fusion genetics two hybrid ComPPI
KANSL1 SMAD3 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS2 SMAD3 25348397 N/A physical interaction ComPPI
CORO1A SMAD3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SNW1 SMAD3 11278756 14525934 18729074 24234451 25348397 physical association two hybrid,experimental interaction detection,far western blotting,pull down,physical interaction,in vitro,tandem affinity purification,two hybrid ComPPI,HPRD,IntAct
ZNF774 SMAD3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FAM90A1 SMAD3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK9 SMAD3 14525934 15326485 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
FHL3 SMAD3 25348397 N/A physical interaction ComPPI
CRX SMAD3 24234451 25348397 25910212 physical association two hybrid array,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
KRT2 SMAD3 14525934 15527767 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ZFYVE9 SMAD3 12154125 14525934 15231748 24234451 25348397 9865696 physical association two hybrid,experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
BAG3 SMAD3 25348397 N/A physical interaction ComPPI
S100A4 SMAD3 25348397 N/A physical interaction ComPPI
VIM SMAD3 14525934 15527767 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CDKN1A SMAD3 25348397 N/A physical interaction ComPPI
SKIL SMAD3 10531062 14525934 15231748 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
TRIB3 SMAD3 25348397 N/A physical interaction ComPPI
BMP7 SMAD3 25348397 N/A physical interaction ComPPI
PPP2R1A SMAD3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMARCC1 SMAD3 25348397 N/A physical interaction ComPPI
MEOX2 SMAD3 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
ZNF329 SMAD3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LMNA SMAD3 25348397 N/A in vitro ComPPI
CSNK1G2 SMAD3 25348397 N/A physical interaction ComPPI
ACTB SMAD3 14525934 15527767 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
SMAD4 SMAD3 10995777 14525934 15231748 15350224 18729074 19135894 21297662 21532621 21597466 21988832 22045334 22442258 24234451 25348397 25609649 25910212 27107012 29997244 9311995 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,two hybrid,experimental interaction detection,pull down,x-ray crystallography,physical interaction,two hybrid array,in vitro,in vivo,tandem affinity purification,proximity ligation assay,two hybrid bait and prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid,two hybrid ComPPI,HPRD,IntAct
PTPN6 SMAD3 25348397 N/A physical interaction,tandem affinity purification ComPPI
JUNB SMAD3 10903323 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ZC3H12A SMAD3 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
PHC2 SMAD3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CPSF7 SMAD3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PITX1 SMAD3 25348397 N/A physical interaction ComPPI
HEYL SMAD3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CSNK1D SMAD3 25348397 N/A physical interaction,tandem affinity purification ComPPI
SERTAD1 SMAD3 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
ERBIN SMAD3 25348397 N/A two hybrid,physical interaction,in vitro,tandem affinity purification ComPPI
SMURF2 SMAD3 11016919 14525934 18729074 22045334 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,isothermal titration calorimetry,peptide array,physical interaction,two hybrid array,in vitro,tandem affinity purification,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
NF2 SMAD3 25348397 N/A physical interaction ComPPI
TOB1 SMAD3 11163184 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FOXG1 SMAD3 11387330 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SMAD1 SMAD3 14525934 15761153 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
DAB2 SMAD3 11387212 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CBL SMAD3 25348397 N/A physical interaction ComPPI
MAPK1 SMAD3 10197981 14525934 16156666 18729074 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
TGFBR2 SMAD3 14525934 25348397 8774881 N/A experimental interaction detection,in vitro ComPPI,HPRD
VAV2 SMAD3 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SP1 SMAD3 10878024 11114293 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RNF111 SMAD3 14525934 14657019 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAPK8 SMAD3 10601313 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
SNRNP70 SMAD3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD7 SMAD3 25348397 N/A physical interaction ComPPI
MYOD1 SMAD3 11711431 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
LCK SMAD3 25348397 N/A physical interaction ComPPI
NOTCH4 SMAD3 14525934 16007227 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NOTCH1 SMAD3 14525934 14638857 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FLI1 SMAD3 25348397 N/A physical interaction ComPPI
GRB2 SMAD3 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NEDD9 SMAD3 11118211 14525934 15051726 15144564 22609948 24234451 25348397 association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
JUN SMAD3 14525934 25348397 9732876 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
AR SMAD3 11280774 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CREBBP SMAD3 14525934 15750622 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RUNX2 SMAD3 10962029 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD2 SMAD3 14525934 18729074 21988832 24234451 25348397 9311995 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
VDR SMAD3 10037600 11278756 14525934 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
NCOA3 SMAD3 25348397 N/A physical interaction ComPPI
TGIF1 SMAD3 25348397 N/A physical interaction ComPPI
NCOA1 SMAD3 25348397 N/A physical interaction ComPPI
EP300 SMAD3 10497242 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
SMAD3 MECOM 14525934 25348397 9665135 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 GLI3 14525934 25348397 9843199 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD3 PRTN3 14525934 15527767 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
SMAD3 DDX5 14525934 15464984 18548003 24234451 25348397 27898060 association,physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
SMAD3 SPTBN1 12543979 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 ZEB1 12743038 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 CEBPB 12202226 12524424 14525934 24234451 25348397 N/A experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
SMAD3 MYC 11804592 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
SMAD3 FOXO4 14525934 15084259 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SMAD3 TFE3 10557285 10973944 12551947 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD3 BRCA2 12165866 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 RUNX3 25348397 N/A physical interaction,in vitro,in vivo ComPPI
SMAD3 HNF4A 25348397 N/A physical interaction,in vitro,in vivo ComPPI
SMAD3 MAPK14 14512875 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SMAD3 SREBF2 14525934 15527767 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
SMAD3 E2F4 12150994 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD3 CAMK2G 24234451 25241761 25348397 physical association physical interaction,in vivo,proximity ligation assay ComPPI,IntAct
SMAD3 MAP3K7 14525934 24234451 25241761 25348397 9380693 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
SMAD3 FOXO3 14525934 15084259 21532621 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SMAD3 MDM4 12483531 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 KPNB1 10846168 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD3 ATF3 12718878 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 CDC16 11691834 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD3 FOXH1 14525934 21828274 24234451 25348397 9858566 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach ComPPI,HPRD,IntAct
SMAD3 AXIN1 11438668 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD3 ZEB2 10400677 12714599 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 STRAP 10757800 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 TGIF2 11427533 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD3 SRY 14525934 15527767 24234451 25348397 association,physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
SMAD3 MED15 12167862 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SMAD3 MAGI2 10681527 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SMAD3 EID2 14525934 14612439 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 CTNNB1 12000714 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD3 CDC27 11691834 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD3 PML 14525934 15356634 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD3 PIAS3 14525934 14691252 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD3 ANAPC10 14525934 15144564 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 ARHGEF6 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD3 BRCA1 14525934 15735739 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 EIF4ENIF1 14525934 14651998 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
SMAD3 GSC 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD3 PEX6 14525934 14651998 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
SMAD3 RAB38 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD3 RASD2 25348397 N/A in vivo ComPPI
SMAD3 RASL12 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD3 RIT1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD3 RRAS2 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD3 SF3B2 14525934 14651998 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
SMAD3 CLASRP 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD3 SMURF1 14525934 15231748 15761153 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SMAD3 SQSTM1 14525934 15761153 21988832 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,confocal microscopy ComPPI,HPRD,IntAct
SMAD3 WEE1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD3 ZMYM2 14525934 14651998 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
SMAD3 NUP214 12917407 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD3 RBL1 12150994 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 NFYC 25348397 N/A physical interaction,in vivo ComPPI
SMAD3 CDC25A 14525934 15798217 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vivo ComPPI,HPRD,IntAct
SMAD3 TSC2 14525934 15066998 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 CDK2 14525934 15241418 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
SMAD3 CDK4 14525934 15241418 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
SMAD3 YBX1 12917425 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
SMAD3 ESR1 11555647 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 ETS1 11590145 14525934 15001984 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
SMAD3 JUND 10220381 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD3 PRKAR2A 14525934 14966294 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD3 PRKAR1B 14525934 14966294 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD3 E2F5 12150994 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SMAD3 DVL1 12650946 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
SMAD3 ESR2 11555647 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD3 TP73 12732139 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD3 CUL1 11359933 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD3 BTRC 11359933 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD3 NUP153 12917407 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD3 AXIN2 11438668 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD3 CTCF 12099698 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD3 HGS 11094085 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 PKHD1 25348397 N/A two hybrid,in vitro ComPPI
SMAD3 PARD3 12650946 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
SMAD3 KAT2B 11058129 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 RBX1 11359933 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
SMAD3 PAEP 15527767 24234451 25348397 association pull down,in vitro ComPPI,IntAct
SMAD3 MYO5B 14525934 15527767 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD3 ZDHHC4 14525934 15527767 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD3 KRT10 14525934 15527767 24234451 25348397 association experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
SMAD3 SF3A1 14525934 15527767 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD3 GTF2IRD1 14525934 15527767 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD3 TPM3 14525934 15527767 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD3 JPH3 14525934 15527767 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD3 IL37 14525934 15527767 20935647 24234451 25348397 27898060 colocalization,physical association anti tag coimmunoprecipitation,experimental interaction detection,in vitro,confocal microscopy ComPPI,HPRD,IntAct,OmniPath
SMAD3 PIAS4 12904571 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
SMAD3 STUB1 14525934 14701756 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD3 HSPA4 12963786 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
SMAD3 AKT1 14525934 16362038 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
SMAD3 PPM1A 14525934 16751101 24234451 25348397 N/A experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
SMAD3 HMGA2 14525934 18832382 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD3 MEN1 11274402 14525934 16189514 16997566 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
SMAD3 FOXO1 14525934 15084259 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 NR3C1 10518526 12902338 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 MAX 12551947 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
SMAD3 KMT2B 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 XRCC6 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 KDM2A 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 MBD1 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SMAD3 GGA1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 CXXC5 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 GMEB1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 PAPPA 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 PCDH1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 SVEP1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 SMAD9 25348397 N/A two hybrid,physical interaction ComPPI
SMAD3 ANK3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 RANBP9 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 MCM3AP 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 CYP11A1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 ZNF83 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 PSMD11 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 CFDP1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 ST6GALNAC2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 EBI3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 SAP130 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 NCOA6 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 EPAS1 14525934 15231748 21057546 24234451 25241761 25348397 27898060 physical association two hybrid,physical interaction,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct,OmniPath
SMAD3 ZBTB16 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 HIVEP1 15231748 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 PLAGL1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 TMED1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 PLAG1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 CSH1 25348397 N/A two hybrid,physical interaction ComPPI
SMAD3 CSH2 14525934 15231748 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
SMAD3 VSIR 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 FLNA 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 RPLP0 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 HEY1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 TGM2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 SKI 12857746 14525934 14525983 19032343 22442258 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,pull down,physical interaction,in vivo,tandem affinity purification,proximity ligation assay ComPPI,HPRD,IntAct
SMAD3 HIPK2 25348397 N/A physical interaction ComPPI
SMAD3 DVL1P1 25348397 N/A physical interaction ComPPI
SMAD3 FOS 14525934 25348397 9732876 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
SMAD3 RUNX1 25348397 N/A physical interaction ComPPI
SMAD3 ACVR1B 25348397 N/A physical interaction ComPPI
SMAD3 CEBPA 25348397 N/A physical interaction ComPPI
SMAD3 CEBPD 25348397 N/A physical interaction ComPPI
SMAD3 LEF1 10890911 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SMAD3 GSK3B 25348397 N/A physical interaction ComPPI
SMAD3 KDM5C 25348397 N/A physical interaction ComPPI
SMAD3 FOXL2 25348397 N/A physical interaction ComPPI
SMAD3 UCHL5 25348397 N/A physical interaction ComPPI
SMAD3 PRDM16 25348397 N/A physical interaction ComPPI
SMAD3 BPTF 25348397 N/A physical interaction ComPPI
SMAD3 HOXC11 25348397 N/A physical interaction ComPPI
SMAD3 SS18L1 25348397 N/A physical interaction ComPPI
SMAD3 ZBTB3 25348397 N/A physical interaction ComPPI
SMAD3 NEDD4 25348397 N/A physical interaction ComPPI
SMAD3 CITED2 16619037 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SMAD3 WWP1 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
SMAD3 ITCH 25348397 N/A physical interaction ComPPI
SMAD3 GRIP1 25348397 N/A physical interaction ComPPI
SMAD3 MYOCD 16224064 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SMAD3 YY1 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 MED24 25348397 N/A physical interaction ComPPI
SMAD3 MED6 25348397 N/A physical interaction ComPPI
SMAD3 HDAC5 25348397 N/A physical interaction ComPPI
SMAD3 HDAC4 25348397 N/A physical interaction ComPPI
SMAD3 SOX9 25348397 N/A physical interaction ComPPI
SMAD3 PITX2 25348397 N/A physical interaction ComPPI
SMAD3 HDAC1 25348397 N/A physical interaction ComPPI
SMAD3 SIN3A 25348397 N/A physical interaction ComPPI
SMAD3 KAT2A 25348397 N/A physical interaction ComPPI
SMAD3 SMARCC2 25348397 N/A physical interaction ComPPI
SMAD3 ARID1A 25348397 N/A physical interaction ComPPI
SMAD3 SMARCA4 25348397 N/A physical interaction ComPPI
SMAD3 TRIM33 21597466 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMAD3 KDM6B 25348397 N/A physical interaction ComPPI
SMAD3 WWP2 18729074 21258410 24234451 25348397 25910212 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,two hybrid array,tandem affinity purification,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
SMAD3 MRTFA 25348397 N/A physical interaction ComPPI
SMAD3 USP9X 25348397 N/A physical interaction ComPPI
SMAD3 NFIC 25348397 N/A physical interaction ComPPI
SMAD3 TP53 12732139 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SMAD3 USP15 25348397 N/A physical interaction ComPPI
SMAD3 CDK8 25348397 N/A physical interaction ComPPI
SMAD3 CDK9 25348397 N/A physical interaction ComPPI
SMAD3 YAP1 25348397 N/A physical interaction ComPPI
SMAD3 DACH1 14525983 24234451 25348397 physical association coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
SMAD3 RGCC 25348397 N/A physical interaction ComPPI
SMAD3 SUV39H1 25348397 N/A physical interaction ComPPI
SMAD3 TCF12 21828274 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SMAD3 PAX6 25348397 N/A physical interaction ComPPI
SMAD3 ZMIZ1 25348397 N/A physical interaction ComPPI
SMAD3 DDX3Y 25348397 N/A physical interaction ComPPI
SMAD3 LEMD3 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 PJA1 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 RPL3 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 ATXN2L 25348397 N/A physical interaction,tandem affinity purification ComPPI
SMAD3 FAM83G 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 CHD8 25348397 N/A physical interaction,tandem affinity purification ComPPI
SMAD3 SLC25A12 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 SLC9A3R2 25348397 N/A physical interaction,tandem affinity purification ComPPI
SMAD3 LRCH1 25348397 N/A physical interaction,tandem affinity purification ComPPI
SMAD3 YTHDF2 25348397 N/A physical interaction,tandem affinity purification ComPPI
SMAD3 EPB41L5 25348397 N/A physical interaction,tandem affinity purification ComPPI
SMAD3 DOCK9 18729074 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 PSPC1 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 DDX4 25348397 N/A physical interaction ComPPI
SMAD3 DDX3X 25348397 N/A physical interaction ComPPI
SMAD3 DNAJA2 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 U2AF2 25348397 N/A physical interaction,tandem affinity purification ComPPI
SMAD3 DHX8 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 SARG 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 ITGB4 25348397 N/A physical interaction,tandem affinity purification ComPPI
SMAD3 CDK11B 25348397 N/A physical interaction ComPPI
SMAD3 CDK11A 25348397 N/A physical interaction,tandem affinity purification ComPPI
SMAD3 RAB11FIP5 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 IRS1 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 SMAD5 25348397 N/A physical interaction ComPPI
SMAD3 DYRK1A 25348397 N/A physical interaction,tandem affinity purification ComPPI
SMAD3 SQOR 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 PABPC1 25348397 N/A physical interaction,tandem affinity purification ComPPI
SMAD3 DCAF7 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 OPA1 25348397 N/A physical interaction,tandem affinity purification ComPPI
SMAD3 USP7 18729074 21988832 24234451 25348397 physical association two hybrid,physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 RPL4 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 TGFBR1 14525934 25348397 9311995 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SMAD3 CHUK 18268325 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SMAD3 APP 25348397 N/A physical interaction ComPPI
SMAD3 HIF1A 24234451 25348397 28471448 colocalization,physical association anti bait coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
SMAD3 ELAC2 25348397 N/A physical interaction ComPPI
SMAD3 RPLP0P6 25348397 N/A physical interaction ComPPI
SMAD3 MTF2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 DEDD 20553715 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
SMAD3 SH2D2A 25348397 N/A physical interaction ComPPI
SMAD3 PIK3CA 25348397 N/A physical interaction ComPPI
SMAD3 KLF5 25348397 N/A physical interaction ComPPI
SMAD3 IRF7 25348397 N/A physical interaction ComPPI
SMAD3 FHL1 25348397 N/A physical interaction ComPPI
SMAD3 FHL2 25348397 N/A physical interaction ComPPI
SMAD3 TGFB1I1 14755691 15561701 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SMAD3 MYD88 21988832 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
SMAD3 PCK2 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
SMAD3 PPP1R12C 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
SMAD3 RNF31 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
SMAD3 TSC22D4 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
SMAD3 SETD2 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
SMAD3 CHRD 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
SMAD3 APMAP 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 PARP4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 PLG 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 LPA 25348397 N/A physical interaction ComPPI
SMAD3 CFH 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 FBLN1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD3 ZMYND11 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 UBQLN4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 TDP2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD3 TF 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 APOB 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 NR4A1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 HP 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 LBP 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 PROX1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 RCVRN 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD3 RELA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD3 TLR4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 GIT2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD3 TANK 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD3 DNAJB4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 ZCCHC14 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 RIOK2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD3 CPTP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD3 OTUB1 25348397 N/A physical interaction ComPPI
SMAD3 TP63 25348397 N/A physical interaction ComPPI
SMAD3 TRIM62 23838884 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SMAD3 FOXM1 25348397 N/A physical interaction ComPPI
SMAD3 MAFK 25348397 N/A physical interaction ComPPI
SMAD3 BACH1 25348397 N/A physical interaction ComPPI
SMAD3 TLE5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SMAD3 BLZF1 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
SMAD3 CCDC33 25348397 N/A physical interaction ComPPI
SMAD3 PPARG 25348397 N/A physical interaction ComPPI
SMAD3 EIF4B 25348397 N/A physical interaction ComPPI
SMAD3 XPO6 25348397 N/A physical interaction ComPPI
SMAD3 LACRT 25348397 N/A physical interaction ComPPI
SMAD3 LDLRAD4 25348397 N/A physical interaction ComPPI
SMAD3 NFIA 25348397 N/A physical interaction ComPPI
SMAD3 DNMT3L 25348397 N/A physical interaction ComPPI
SMAD3 TRIM25 25348397 N/A physical interaction ComPPI
SMAD3 WWOX 25348397 N/A physical interaction ComPPI
SMAD3 DROSHA 18548003 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
SMAD3 JPH1 15527767 24234451 25348397 association pull down ComPPI,IntAct
SMAD3 AGL 15527767 24234451 25348397 association pull down ComPPI,IntAct
SMAD3 CCNT1 19914168 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
SMAD3 ARHGEF7 25348397 N/A tandem affinity purification ComPPI
SMAD3 HSPA1A 18729074 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SMAD3 HSPA1B 25348397 N/A tandem affinity purification ComPPI
SMAD3 MTMR4 20061380 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
SMAD3 DNAJB5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
SMAD3 RANBP3 21960005 24234451 25348397 physical association pull down ComPPI,IntAct
SMAD3 UBC 18821706 22045334 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation ComPPI,IntAct,OmniPath
SMAD3 DVL2 22609948 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SMAD3 PRMT5 19032343 24234451 25348397 association cosedimentation through density gradient ComPPI,IntAct
SMAD3 GLI2 24234451 25348397 25670079 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
SMAD3 SBK3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BUB3 SMAD3 25348397 N/A physical interaction,tandem affinity purification ComPPI
RPA1 SMAD3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
AATF SMAD3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ISL1 SMAD3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NEDD4L SMAD3 25348397 N/A anti tag coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
TCP1 SMAD3 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
CFLAR SMAD3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PSMB1 SMAD3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ATF2 SMAD3 10085140 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
IL36RN SMAD3 15527767 24234451 25348397 association pull down ComPPI,IntAct
SIK3 SMAD3 25348397 N/A physical interaction ComPPI
PRDM4 SMAD3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 PAX8 14525934 14623893 N/A experimental interaction detection HPRD
SMAD3 ZNF8 12370310 14525934 N/A experimental interaction detection,two hybrid HPRD
SMAD3 SMAD3 11707452 14525934 15138260 18729074 22045334 24234451 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,tandem affinity purification HPRD,IntAct
SKOR2 SMAD3 14525934 16200078 N/A experimental interaction detection HPRD
RARG SMAD3 14525934 14603262 27898060 N/A experimental interaction detection,two hybrid HPRD,OmniPath
NKX2-1 SMAD3 18003659 24234451 physical association gal4 vp16 complementation IntAct
SMAD3 FOXA1 18003659 24234451 physical association anti tag coimmunoprecipitation IntAct
WWTR1 SMAD3 21084559 27898060 stimulant N/A OmniPath
TUBB SMAD3 17429065 27898060 inhibition N/A OmniPath
PIAS3 SMAD3 14691252 27898060 stimulant N/A OmniPath
TGFBR2 SMAD3 15104092 27898060 8774881 stimulant N/A OmniPath
CREB1 SMAD3 16862174 27898060 stimulant N/A OmniPath
UCHL5 SMAD3 16027725 27898060 stimulant N/A OmniPath
MYC SMAD3 11804592 27898060 inhibition,stimulant N/A OmniPath
SMAD3 PIN1 19122240 19920136 21685363 21988832 27898060 N/A N/A OmniPath
PIN1 SMAD3 19122240 19920136 21685363 21988832 27898060 N/A N/A OmniPath
KAT2A SMAD3 11058129 15009097 150091 27898060 stimulant N/A OmniPath
CDK2 SMAD3 15241418 15520018 16156666 19114991 19218245 19413330 20068231 25241761 27898060 9380693 inhibition N/A OmniPath
SMAD3 FOXO1 15084259 18391971 27898060 stimulant N/A OmniPath
ESR1 SMAD3 11555647 2020774 27898060 N/A N/A OmniPath
SMAD3 ESR1 11555647 2020774 27898060 stimulant N/A OmniPath
CDK9 SMAD3 19914161 19914168 27898060 inhibition,stimulant N/A OmniPath
SMAD3 GATA3 11790301 27898060 stimulant N/A OmniPath
SMAD3 PAX8 14623893 27898060 inhibition N/A OmniPath
AKT1 SMAD3 15048128 15104092 16362038 1636204 25241761 27898060 inhibition,stimulant N/A OmniPath
SMAD3 IRS1 18729074 27898060 N/A N/A OmniPath
PPM1A SMAD3 16751101 27898060 inhibition,stimulant N/A OmniPath
PML SMAD3 15356634 27898060 stimulant N/A OmniPath
MYD88 SMAD3 21988832 27898060 N/A N/A OmniPath
SMAD3 PTPN6 18729074 27898060 N/A N/A OmniPath
ATF2 SMAD3 10085140 27898060 N/A N/A OmniPath
SMAD3 ATF2 10085140 27898060 N/A N/A OmniPath
SMAD3 MAX 12551947 25241761 27898060 stimulant N/A OmniPath
MAPK3 SMAD3 10197981 27898060 inhibition,stimulant N/A OmniPath
SMAD3 CREBBP 10497242 15467747 15750622 15849193 15990875 17283070 18003620 19589780 27898060 stimulant N/A OmniPath
CREBBP SMAD3 10497242 15467747 15750622 15849193 15990875 17283070 18003620 19589780 27898060 inhibition N/A OmniPath
MAPK14 SMAD3 14512875 15520018 27898060 stimulant N/A OmniPath
SMAD3 GNRHR 15561800 27898060 stimulant N/A OmniPath
SMAD3 LEF1 10890911 15750622 27898060 stimulant N/A OmniPath
SMAD3 PAX6 17251190 27898060 inhibition N/A OmniPath
BCAR1 SMAD3 18321991 27898060 inhibition N/A OmniPath
SMAD3 AR 11248024 11280774 11707452 12226080 27898060 inhibition,stimulant N/A OmniPath
CDK4 SMAD3 15241418 15520018 19114991 19413330 20068231 25241761 27898060 inhibition N/A OmniPath
SMAD3 IRF7 14729983 27898060 N/A N/A OmniPath
IRF7 SMAD3 14729983 27898060 N/A N/A OmniPath
EP300 SMAD3 10497242 10575014 11058129 11134049 12743039 15133024 15345715 15588252 15623506 15824515 16109717 16876108 17469184 20564330 21269274 21567395 27898060 9679056 9843571 inhibition,stimulant N/A OmniPath
MAPK1 SMAD3 10197981 15241418 15520018 16156666 1615667 18729074 19914161 19914168 19917253 19920136 20659902 20736297 21477078 26297431 26497676 27898060 9380693 inhibition,stimulant N/A OmniPath
SMAD3 MAPK1 10197981 15241418 16156666 1615667 18729074 19914161 19914168 27898060 N/A N/A OmniPath
NOTCH1 SMAD3 14638857 27898060 N/A N/A OmniPath
SMAD3 NOTCH1 14638857 27898060 stimulant N/A OmniPath
AXIN1 SMAD3 11438668 27898060 stimulant N/A OmniPath
PPP2CA SMAD3 19951945 20704570 27898060 inhibition,stimulant N/A OmniPath
SMAD3 NKX2-1 18003659 27898060 inhibition N/A OmniPath
DVL1 SMAD3 12650946 27898060 stimulant N/A OmniPath
SMAD3 SMAD4 10092624 10531362 10878024 10995777 11114293 11927552 12145309 12167862 12419246 12543979 12672795 12732634 12794086 12917407 12957874 14764653 15084259 15231748 15350224 15467747 15588252 15761153 15922743 17226765 17283070 17591701 18729074 19135894 19139564 19768112 19917253 20142324 20564330 21145499 21297662 21532621 21988832 22045334 22310290 22442258 23788427 24157709 24382352 24584437 25514493 25609649 26555259 27898060 9111321 9311995 9843571 9892009 stimulant N/A OmniPath
HIF1A SMAD3 11486006 12228247 27898060 N/A N/A OmniPath
KAT2B SMAD3 11058129 15009097 15994459 22995475 27898060 stimulant N/A OmniPath
SMAD3 DAPK1 11740493 27898060 stimulant N/A OmniPath
GSK3B SMAD3 18172167 21310903 27898060 inhibition,stimulant N/A OmniPath
SMAD3 STAT3 11257503 27898060 stimulant N/A OmniPath
SMAD3 TCF7L2 15292219 27898060 stimulant N/A OmniPath
EIF4E SMAD3 12150994 27898060 stimulant N/A OmniPath
CAMK2A SMAD3 15241418 27898060 9380693 N/A N/A OmniPath
BTRC SMAD3 11359933 27898060 inhibition N/A OmniPath
NR3C1 SMAD3 10518526 12902338 27898060 stimulant N/A OmniPath
TGFBR1 SMAD3 12543979 15104092 19458083 19701891 19758997 25872870 27898060 9311995 inhibition,stimulant N/A OmniPath
PIAS4 SMAD3 12815042 12904571 27898060 inhibition,stimulant N/A OmniPath
JUN SMAD3 10220381 10903323 11306568 21829441 27898060 9732876 stimulant N/A OmniPath
SMAD3 JUN 10220381 10903323 11306568 21829441 27898060 9732876 stimulant N/A OmniPath
SMAD3 RUNX2 10531362 10962029 11331591 21986102 27898060 inhibition N/A OmniPath
ZFYVE9 SMAD3 12154125 15231748 15356634 18729074 20515759 26186194 27898060 9865696 stimulant N/A OmniPath
NEDD4L SMAD3 19917253 22921829 24071738 26555259 27898060 inhibition N/A OmniPath
RNF111 SMAD3 14657019 17341133 17591695 18451154 18950738 23530056 27898060 stimulant N/A OmniPath
SMAD7 SMAD3 10559222 26555259 27898060 9892110 inhibition,stimulant N/A OmniPath
SMAD3 VAV2 18729074 27898060 N/A N/A OmniPath
SKIL SMAD3 10531062 11306568 11691834 12426322 12764135 12793438 15231748 16959829 17469184 27898060 stimulant N/A OmniPath
NUP214 SMAD3 12917407 27898060 stimulant N/A OmniPath
KPNB1 SMAD3 10846168 27898060 stimulant N/A OmniPath
SMAD3 FOXP3 15367216 19701891 27898060 stimulant N/A OmniPath
SMAD6 SMAD3 27898060 9892110 inhibition,stimulant N/A OmniPath
SMURF1 SMAD3 10458166 15221015 1522102 15231748 15761153 27898060 stimulant N/A OmniPath
CDK8 SMAD3 19914161 19914168 27898060 inhibition,stimulant N/A OmniPath
TRIM33 SMAD3 16751102 1800362 18003620 19917253 22196728 24382352 27898060 stimulant N/A OmniPath
SMAD3 ERBIN 12650946 17591701 18003620 18729074 27898060 N/A N/A OmniPath
ERBIN SMAD3 12650946 17591701 18003620 18729074 27898060 stimulant N/A OmniPath
NUP153 SMAD3 12917407 27898060 stimulant N/A OmniPath
SKI SMAD3 10549282 10575014 11306568 12154125 12426322 12732634 12764135 12793438 12857746 12874272 14525983 14699069 17283070 17469184 19032343 19049980 19875456 25670202 27898060 inhibition,stimulant N/A OmniPath
ACVR1B SMAD3 27898060 9605406 stimulant N/A OmniPath
FBXW11 SMAD3 11359933 27898060 stimulant N/A OmniPath
SMAD3 FOXA1 18003659 27898060 inhibition N/A OmniPath
EID2 SMAD3 14612439 27898060 inhibition N/A OmniPath
CTDSPL SMAD3 17035229 27898060 stimulant N/A OmniPath
MECOM SMAD3 27898060 9665135 inhibition N/A OmniPath
RANBP3 SMAD3 19289081 20704570 21960005 27898060 inhibition N/A OmniPath
MTMR4 SMAD3 20061380 27898060 inhibition N/A OmniPath
CTDSP1 SMAD3 17035229 27898060 stimulant N/A OmniPath
CSNK1G2 SMAD3 18794808 27898060 inhibition N/A OmniPath
CTDSP2 SMAD3 17035229 27898060 stimulant N/A OmniPath
PPP2CB SMAD3 19951945 27898060 N/A N/A OmniPath

Visualization










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