GENE：BAX
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | BAX |
| FullNmae | BCL2 associated X, apoptosis regulator |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:959 |
| EnsembleID | ENSG00000087088 |
| Uniprot | Q07812 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| BAX | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BAX | pyroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| BAX | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BAX | necroptosis | 38335615 | The results showed that SS-induced mitochondrial reactive oxygen species (mtROS) accumulation activated the BAX/Bcl-2/caspase 3 pathway to trigger apoptosis and RIPK1/RIPK3/p-MLKL to trigger necroptosis. | retulator signature |
| BAX | necroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| BAX | mpt | 34926454 | Although the MPTP is defined by an increase in inner mitochondrial membrane permeability, the expression of pro-apoptotic Bcl-2 family members, Bax and Bak localization to the outer mitochondrial membrane is required for MPTP-dependent mitochondrial dysfunction and subsequent necrotic cell death. | retulator signature |
| BAX | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BAX | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BAX | ferroptosis | 35853302 | HDI regulated VDAC2/3 activity by promoting Bax via inhibiting Bcl2, thereby inducing ferroptosis in lung adenocarcinoma cells. | retulator signature |
| BAX | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BAX | apoptosis | 28256197 | The subcellular localization of Bax plays a crucial role during apoptosis. | retulator signature |
| BAX | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| BAX | GO:0001541,GO:0001764,GO:0001777,GO:0001782,GO:0001783,GO:0001822,GO:0001836,GO:0001836,GO:0001844,GO:0001974,GO:0002262,GO:0002352,GO:0002358,GO:0002904,GO:0005515,GO:0005634,GO:0005634,GO:0005635,GO:0005737,GO:0005739,GO:0005741,GO:0005741,GO:0005741,GO:0005757,GO:0005783,GO:0005789,GO:0005829,GO:0005829,GO:0006687,GO:0006808,GO:0006915,GO:0006915,GO:0006915,GO:0006919,GO:0006919,GO:0007281,GO:0008053,GO:0008053,GO:0008289,GO:0008625,GO:0008630,GO:0008635,GO:0008637,GO:0009566,GO:0009636,GO:0009651,GO:0010248,GO:0010332,GO:0010524,GO:0010917,GO:0015267,GO:0015267,GO:0016020,GO:0021854,GO:0021987,GO:0030544,GO:0031334,GO:0032091,GO:0032469,GO:0032471,GO:0032976,GO:0033137,GO:0033599,GO:0034620,GO:0034644,GO:0035234,GO:0042475,GO:0042802,GO:0042803,GO:0042803,GO:0042981,GO:0043065,GO:0043065,GO:0043065,GO:0043524,GO:0043525,GO:0043653,GO:0045136,GO:0046666,GO:0046930,GO:0046982,GO:0046982,GO:0048087,GO:0048147,GO:0048515,GO:0048597,GO:0048678,GO:0048873,GO:0051209,GO:0051281,GO:0051434,GO:0051434,GO:0051726,GO:0051881,GO:0060011,GO:0060041,GO:0060057,GO:0060058,GO:0060068,GO:0060402,GO:0070059,GO:0070059,GO:0070062,GO:0070242,GO:0070584,GO:0071944,GO:0072332,GO:0090200,GO:0090200,GO:0097049,GO:0097136,GO:0097144,GO:0097145,GO:0097190,GO:0097191,GO:0097192,GO:0097193,GO:0097435,GO:0098586,GO:1900103,GO:1902262,GO:1902263,GO:1902445,GO:1902512,GO:1903896,GO:1904019,GO:1904037,GO:1990117,GO:2000243,GO:2000673,GO:2001234,GO:2001244 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| BAX | hsa:581 | path:hsa01521 | EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa01522 | Endocrine resistance - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa01524 | Platinum drug resistance - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa04210 | Apoptosis - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa04932 | Non-alcoholic fatty liver disease - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05012 | Parkinson disease - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05014 | Amyotrophic lateral sclerosis - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05016 | Huntington disease - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05131 | Shigellosis - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05132 | Salmonella infection - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05160 | Hepatitis C - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05161 | Hepatitis B - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05162 | Measles - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05164 | Influenza A - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05168 | Herpes simplex virus 1 infection - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05210 | Colorectal cancer - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05213 | Endometrial cancer - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05214 | Glioma - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05216 | Thyroid cancer - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05218 | Melanoma - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
| BAX | hsa:581 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BCL2 | BAX | 11704864 16227588 17446862 17891140 20709625 21641962 22039431 22705850 23064052 23180781 23377657 23430059 23850759 26192618 7644501 8358790 8929532 9872359 | association,physical association | anti tag coimmunoprecipitation | ACSN,InnateDB |
| BAX | EIF2S2 | 12601012 12667446 16246152 23850759 26192618 | interaction type | N/A | ACSN |
| BAX | EIF2S3 | 12601012 12667446 16246152 23850759 26192618 | interaction type | N/A | ACSN |
| BCL2L11 | BAX | 10198631 12419244 15486085 15724238 23430059 23850759 26192618 9430630 | interaction type | N/A | ACSN |
| PRKCZ | BAX | 10873802 10934475 10954424 14766748 15642728 17525161 20505164 26192618 | interaction type | N/A | ACSN |
| PYCARD | BAX | 14730312 19062087 19104081 19968986 23180781 26192618 26885855 27048821 27066895 27984721 | interaction type,physical association | anti tag coimmunoprecipitation,pull down | ACSN,InnateDB |
| NFKB1 | BAX | 12676992 15613549 21725609 23178297 23572150 26192618 7834749 | interaction type | N/A | ACSN |
| CAPN1 | BAX | 19931333 21887410 23242420 26192618 | interaction type | N/A | ACSN |
| CAPN2 | BAX | 21887410 23242420 26192618 | interaction type | N/A | ACSN |
| BAX | TRAF2 | 20709625 21641962 22039431 23064052 23377657 23430059 23850759 26192618 26587781 7644501 8358790 | interaction type | N/A | ACSN |
| BAX | MCL1 | 14766748 20709625 21641962 22039431 23064052 23180781 23377657 23430059 23850759 26192618 26587781 7644501 8358790 | interaction type,physical association | anti tag coimmunoprecipitation | ACSN,InnateDB |
| EIF2B1 | BAX | 16246152 26192618 | interaction type | N/A | ACSN |
| EIF2B3 | BAX | 16246152 26192618 | interaction type | N/A | ACSN |
| EIF2B4 | BAX | 16246152 26192618 | interaction type | N/A | ACSN |
| EIF2B5 | BAX | 16246152 26192618 | interaction type | N/A | ACSN |
| NDUFS1 | BAX | 16246152 26192618 | interaction type | N/A | ACSN |
| BAX | EIF2S1 | 26192618 | interaction type | N/A | ACSN |
| PPP1CA | BAX | 17274640 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| BAX | PRKCZ | 17525161 23180781 | phosphorylation reaction,physical association | anti tag coimmunoprecipitation,protein kinase assay | InnateDB |
| BAX | BCL2 | 17525161 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| AKT1 | BAX | 14766748 23180781 | phosphorylation reaction | in-gel kinase assay | InnateDB |
| BAX | BCL2L1 | 14766748 22705850 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| BCL2A1 | BAX | 14766748 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| EPAS1 | BAX | 17324924 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| EP300 | BAX | 15286281 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| BAX | IRF3 | 20360684 23180781 | physical association | pull down | InnateDB |
| EGR1 | BAX | 19137013 20690147 23180781 | physical association | anti tag coimmunoprecipitation,electrophoretic mobility supershift assay | InnateDB |
| BAX | YAP1 | 19137013 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| BCL2L1 | BAX | 22705850 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TP53 | BAX | 19901969 20567883 22480684 23148227 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| RUNX1 | BAX | 23148227 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| BAX | E2F1 | 22480684 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| BAX | PTGS2 | 21187340 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| BAX | BAX | 10629050 18097445 26467481 | interaction type,bind,up-regulates,up-regulates activity,relocalization reaction | N/A | Signor |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | BAX | 17213822 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | BAX | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | BAX | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GFI1 | BAX | 17213822 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYC | BAX | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| TP53 | BAX | 10101800 10559267 10566557 11104574 11278953 11756653 12851404 15851483 15988033 17280505 17693666 18172861 18971253 19067706 20673369 21859835 22532570 22732402 9000137 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| TP73 | BAX | 19067706 21245298 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| SP1 | BAX | 11278953 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMARCA4 | BAX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | BAX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | BAX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | BAX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | BAX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | BAX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | BAX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| AATF | BAX | 22909821 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ABL1 | BAX | 11753601 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ATM | BAX | 16214353 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DMAP1 | BAX | 24559687 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ELL | BAX | 15851483 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ERCC2 | BAX | 22387547 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HIF1A | BAX | 15706354 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ING1 | BAX | 15662138 16325212 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ING4 | BAX | 20707719 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MLLT10 | BAX | 15851483 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MLLT3 | BAX | 15851483 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYCN | BAX | 19885598 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | BAX | 18158998 20056115 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NR3C1 | BAX | 17496926 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PAX5 | BAX | 22105368 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PER1 | BAX | 19675098 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PML | BAX | 16007146 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | BAX | 18158998 20056115 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | BAX | 11278953 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT1 | BAX | 17346710 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP63 | BAX | 16007146 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| WWTR1 | BAX | 22470139 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003380CC | BAX | 18692484 | rna interference,inhibition | western blot | miRSponge |
| URS00005CC20C | BAX | 20542001 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr | TarBase |
| URS0000521626 | BAX | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00003380CC | BAX | 17612493 18692484 25416803 | mrna cleavage,inhibition | array technology,western blot | TarBase |
| URS0000065D58 | BAX | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS000031B6ED | BAX | 23622248 24216611 25416803 | mrna cleavage,inhibition | array technology,western blot,clash | TarBase |
| URS0000160683 | BAX | 23408966 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS00001012BC | BAX | 24356076 25416803 | mrna cleavage,inhibition | array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00000EED18 | BAX | 25416803 27610823 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS000041CB9C | BAX | 25416803 27499071 | mrna cleavage,inhibition | western blot | TarBase |
| URS00003BBF48 | BAX | 25416803 27261578 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GSK3B | BAX | 22135298 | phosphorylation | N/A | PhosphoSite |
| PRKCZ | BAX | 22135298 | phosphorylation | N/A | PhosphoSite |
| TOMM40 | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | TOMM40 | 25361965 | interaction type | N/A | PTMCode2 |
| SLC25A4 | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | SLC25A4 | 25361965 | interaction type | N/A | PTMCode2 |
| SH3GLB1 | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | SH3GLB1 | 25361965 | interaction type | N/A | PTMCode2 |
| BCL2L10 | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | BCL2L10 | 25361965 | interaction type | N/A | PTMCode2 |
| BCL2A1 | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | BCL2A1 | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | MOAP1 | 25361965 | interaction type | N/A | PTMCode2 |
| MOAP1 | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | BCL2L1 | 25361965 | interaction type | N/A | PTMCode2 |
| BCL2L1 | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | BID | 25361965 | interaction type | N/A | PTMCode2 |
| BID | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | PMAIP1 | 25361965 | interaction type | N/A | PTMCode2 |
| PMAIP1 | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | BCL2 | 25361965 | interaction type | N/A | PTMCode2 |
| BCL2 | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | SFN | 25361965 | interaction type | N/A | PTMCode2 |
| SFN | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | BCL2L11 | 25361965 | interaction type | N/A | PTMCode2 |
| BCL2L11 | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | MCL1 | 25361965 | interaction type | N/A | PTMCode2 |
| MCL1 | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | KCNA3 | 25361965 | interaction type | N/A | PTMCode2 |
| KCNA3 | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | ERN1 | 25361965 | interaction type | N/A | PTMCode2 |
| ERN1 | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| BCL2L2 | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | BCL2L2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BCL2L11 | BAX | 17289999 17525735 18948948 19427863 21199865 23235460 23374347 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,fluorescent resonance energy transfer,molecular sieving,nuclear magnetic resonance,surface plasmon resonance,physical interaction | ComPPI,IntAct |
| ANP32B | BAX | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| SH3GLB1 | BAX | 11161816 11259440 14525934 19074440 24234451 25348397 | physical association | anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
| BAG3 | BAX | 25348397 | N/A | physical interaction | ComPPI |
| CRYAA | BAX | 25348397 | N/A | physical interaction | ComPPI |
| CRYAB | BAX | 25348397 | N/A | physical interaction | ComPPI |
| PCBP1 | BAX | 25348397 | N/A | physical interaction | ComPPI |
| PSMC3 | BAX | 25348397 | N/A | physical interaction | ComPPI |
| TOMM22 | BAX | 25348397 | N/A | physical interaction | ComPPI |
| VCP | BAX | 25348397 | N/A | physical interaction | ComPPI |
| XIAP | BAX | 25348397 | N/A | physical interaction | ComPPI |
| CASP9 | BAX | 25348397 | N/A | physical interaction | ComPPI |
| BCL2L2 | BAX | 17289999 18981409 21199865 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CYCS | BAX | 25348397 | N/A | physical interaction | ComPPI |
| BCL2L1 | BAX | 11283018 14525934 15131699 17525735 24234451 25241761 25348397 9111042 9153240 9742125 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay,two hybrid | ComPPI,HPRD,IntAct |
| BAD | BAX | 19427863 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MOAP1 | BAX | 11060313 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| CASP3 | BAX | 25348397 | N/A | physical interaction | ComPPI |
| PRKCE | BAX | 17668322 24234451 25348397 27898060 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct,OmniPath |
| GSK3B | BAX | 20080742 24234451 25348397 | phosphorylation reaction | phosphorylation reaction,protein kinase assay | ComPPI,IntAct |
| CLU | BAX | 16113678 19118032 19177010 21567405 23538443 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| YWHAB | BAX | 25348397 | N/A | physical interaction | ComPPI |
| SERPINH1 | BAX | 25348397 | N/A | physical interaction | ComPPI |
| UBB | BAX | 25348397 | N/A | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI |
| UBC | BAX | 25348397 | N/A | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI |
| RPS27A | BAX | 25348397 | N/A | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI |
| UBA52 | BAX | 25348397 | N/A | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI |
| IRF3 | BAX | 20360684 24234451 25348397 | N/A | pull down | ComPPI,IntAct |
| XRCC5 | BAX | 25348397 | N/A | physical interaction | ComPPI |
| KCNA3 | BAX | 14525934 18818304 24234451 25348397 27898060 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct,OmniPath |
| MCL1 | BAX | 10837489 14525934 15077116 17525735 18981409 19968986 21199865 21458670 24234451 25348397 | colocalization,association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,fluorescence technology,x-ray crystallography,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| PRDX1 | BAX | 25348397 | N/A | physical interaction | ComPPI |
| CASP7 | BAX | 25348397 | N/A | physical interaction | ComPPI |
| CASP8 | BAX | 25348397 | N/A | physical interaction | ComPPI |
| PPP1CA | BAX | 14525934 17274640 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| MAP2K1 | BAX | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| XRCC6 | BAX | 15205477 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| UHRF2 | BAX | 21952639 24234451 25348397 | physical association | physical interaction,antibody array | ComPPI,IntAct |
| VDAC1 | BAX | 12767928 14525934 25348397 9843949 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| PKM | BAX | 25348397 | N/A | physical interaction | ComPPI |
| YWHAQ | BAX | 12426317 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| PSMC5 | BAX | 25348397 | N/A | physical interaction | ComPPI |
| GEMIN2 | BAX | 25348397 | N/A | physical interaction | ComPPI |
| MT-RNR2 | BAX | 12732850 24234451 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,fluorescence polarization spectroscopy,in vitro,in vivo | ComPPI,IntAct |
| YY1 | BAX | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SFN | BAX | 11574543 14525934 24234451 25348397 | physical association | coimmunoprecipitation,experimental interaction detection,in vivo | ComPPI,HPRD,IntAct |
| HSPA4 | BAX | 25348397 | N/A | physical interaction | ComPPI |
| HDAC6 | BAX | 25348397 | N/A | physical interaction | ComPPI |
| BCL2A1 | BAX | 10753914 14525934 14766748 25348397 27898060 | N/A | two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| BAK1 | BAX | 11571294 14525934 15901672 16439990 17289999 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| LIG3 | BAX | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PYCARD | BAX | 14730312 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,confocal microscopy | ComPPI,IntAct |
| SERPINB12 | BAX | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BCL2 | BAX | 14525934 15231068 16642033 17097560 17289999 17525735 18981409 21199865 21458670 21671007 24234451 25348397 26004684 8358790 9111042 9388232 9463381 | colocalization,association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescence technology,physical interaction,enzyme linked immunosorbent assay,fluorescence microscopy,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
| BCL2L10 | BAX | 11278245 14525934 23235460 24234451 25348397 | physical association | anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| PMAIP1 | BAX | 14525934 15705586 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| BAX | NOL3 | 14525934 15383280 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| BAX | BBC3 | 25348397 | N/A | two hybrid | ComPPI |
| BAX | ERN1 | 14525934 16645094 24234451 25348397 | N/A | experimental interaction detection,pull down,in vitro,in vivo | ComPPI,HPRD,IntAct |
| BAX | SLC25A4 | 14525934 25348397 27898060 9748162 | N/A | two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| BAX | HSPD1 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | MEPCE | 25348397 | N/A | physical interaction | ComPPI |
| BAX | TOMM40 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | RNF144B | 20300062 24234451 25348397 | colocalization,physical association | anti bait coimmunoprecipitation,physical interaction,blue native page,fluorescence microscopy | ComPPI,IntAct |
| BAX | PARK7 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | CRYAA2 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | ZBTB24 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | GIMAP5 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | LRRK2 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | BCL2L12 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | PRDX2 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | ERCC6 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | ERCC6 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BAX | PNPLA6 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | PRSS23 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BAX | EDRF1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BAX | NIN | 25348397 | N/A | physical interaction | ComPPI |
| BAX | BDP1 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | NSFL1C | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BAX | ATAD5 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BAX | C18ORF21 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BAX | BID | 14525934 15574335 17289999 20956295 23374347 24234451 25241761 25348397 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,surface plasmon resonance,x-ray crystallography,physical interaction,proximity ligation assay,surface plasmon resonance array,two hybrid | ComPPI,HPRD,IntAct |
| BAX | SNCA | 24234451 25241761 25348397 | physical association | physical interaction,proximity ligation assay | ComPPI,IntAct |
| BAX | TP53 | 24234451 25241761 25348397 | physical association | physical interaction,proximity ligation assay | ComPPI,IntAct |
| BAX | COQ9 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | NMES1 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | OCIAD1 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | PPM1J | 25348397 | N/A | physical interaction | ComPPI |
| BAX | BCL2L15 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | HSD17B10 | 24234451 25348397 29128334 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| BAX | MT-ND5 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| BAX | ATPAF1 | 19968986 24234451 25348397 | colocalization | cosedimentation through density gradient | ComPPI,IntAct |
| BAX | TOMM20 | 20300062 24234451 25348397 | colocalization | fluorescence microscopy | ComPPI,IntAct |
| BAX | UVRAG | 21597469 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down | ComPPI,IntAct |
| BAX | VRK2 | 23449449 24234451 25348397 27898060 | colocalization | confocal microscopy | ComPPI,IntAct,OmniPath |
| BAX | LEF1 | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| BAX | RTL10 | 23055042 24234451 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| BAX | AKT1 | 24234451 25348397 26763134 | phosphorylation reaction | enzymatic study | ComPPI,IntAct |
| BAX | HSF2BP | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| BAX | NDUFAF8 | 24234451 25348397 27499296 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| BAX | COX6B1 | 24234451 25348397 27499296 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| HSCB | BAX | 24234451 25348397 28380382 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| BAX | BBC3 | 14525934 15574335 | N/A | two hybrid | HPRD |
| BAX | BAX | 10620504 14963330 1558161 17289999 17668322 18547146 18835031 19062087 19074440 19767770 20360684 20850011 22198199 23374347 24234451 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cross-linking study,experimental interaction detection,fluorescent resonance energy transfer,molecular sieving,x-ray crystallography,blue native page,comigration in sds page,polymerization | IntAct |
| PRKN | BAX | 22460798 27898060 | N/A | N/A | OmniPath |
| HSPD1 | BAX | 18266962 27898060 | inhibition | N/A | OmniPath |
| PYCARD | BAX | 14730312 16964285 17464323 19062087 19968986 27898060 | stimulant | N/A | OmniPath |
| BAX | BCL2L1 | 11283018 12137781 12853473 14766748 15131699 19427863 21199865 21852238 22705850 25241761 26186194 26496610 27898060 7650488 8798452 9027312 9111042 9153240 9742125 9824152 | N/A | N/A | OmniPath |
| BCL2L1 | BAX | 11283018 12137781 12853473 14766748 15131699 18178565 19427863 21199865 21852238 22705850 25241761 26186194 26496610 27898060 7650488 8596636 8798452 9027312 9111042 9153240 9670005 9742125 9824152 | inhibition | N/A | OmniPath |
| BAX | APAF1 | 11709054 27898060 | stimulant | N/A | OmniPath |
| GFI1 | BAX | 12874834 27898060 | inhibition | N/A | OmniPath |
| BID | BAX | 10629050 12242151 15574335 17052454 17289999 23374347 25241761 27898060 8918887 | stimulant | N/A | OmniPath |
| BCL2 | BAX | 10620799 10716992 14980220 15231068 16642033 17097560 17289999 17525161 21199865 21458670 21671007 21778226 22262057 22705850 23479509 26004684 27898060 8183370 8358790 8631771 9111042 9115213 9388232 9463381 9742125 | inhibition | N/A | OmniPath |
| BAX | BAD | 27898060 9388232 | inhibition | N/A | OmniPath |
| AKT1 | BAX | 14766748 26763134 27898060 | inhibition | N/A | OmniPath |
| SH3GLB1 | BAX | 11161816 11259440 16227588 27898060 | stimulant | N/A | OmniPath |
| BAK1 | BAX | 11571294 15901672 16439990 21712378 27898060 | stimulant | N/A | OmniPath |
| BAX | VDAC1 | 10365962 12767928 15637055 16189514 27898060 9843949 | stimulant | N/A | OmniPath |
| TRIM28 | BAX | 17942393 27898060 | inhibition | N/A | OmniPath |
| BAX | CYCS | 10629050 11326099 12232790 27898060 9461218 9843949 | stimulant | N/A | OmniPath |
| TP53 | BAX | 14963330 16151013 25241761 27898060 7834749 | stimulant | N/A | OmniPath |
| BAX | TP53 | 19901969 25241761 27898060 | N/A | N/A | OmniPath |
| MCL1 | BAX | 10837489 14766748 15077116 17289999 19148187 21199865 21458670 21566062 26186194 27898060 | inhibition | N/A | OmniPath |
| MAPK14 | BAX | 15642728 27898060 | stimulant | N/A | OmniPath |
| PRKCZ | BAX | 14766748 15642728 16679323 17525161 17911107 27898060 | inhibition | N/A | OmniPath |
| BAX | AIFM1 | 12232790 27898060 | stimulant | N/A | OmniPath |
| IRF3 | BAX | 20360684 27898060 | N/A | N/A | OmniPath |
| BBC3 | BAX | 15574335 27898060 | stimulant | N/A | OmniPath |
| PMAIP1 | BAX | 15705586 27898060 | stimulant | N/A | OmniPath |
| BCL2L11 | BAX | 11301022 11997495 12198137 12242151 15721256 17289999 18948948 19427863 22492984 27898060 | stimulant | N/A | OmniPath |
| NOL3 | BAX | 15383280 27898060 | stimulant | N/A | OmniPath |
| XRCC6 | BAX | 15205477 18710944 19118032 19177010 19247369 21042904 25299772 27898060 | inhibition | N/A | OmniPath |
| BCL2L2 | BAX | 17289999 17452531 18178565 21199865 27898060 | inhibition | N/A | OmniPath |
| PPP2CA | BAX | 16679323 27898060 | N/A | N/A | OmniPath |
| GSK3B | BAX | 15525785 27898060 | stimulant | N/A | OmniPath |
| MAPK8 | BAX | 15071501 18471544 27898060 | stimulant | N/A | OmniPath |
| BAX | HTRA2 | 12232790 14585074 27898060 | stimulant | N/A | OmniPath |
| BAX | ENDOG | 12232790 27898060 | stimulant | N/A | OmniPath |
| BAX | DIABLO | 11782443 12232790 12670894 14585074 27898060 | stimulant | N/A | OmniPath |
| BAX | COX5B | 11139284 27898060 | stimulant | N/A | OmniPath |
| BBC3 | BAX | 1557433 15574335 19439449 27898060 | stimulant | N/A | OmniPath |
| PPP2CB | BAX | 16679323 27898060 | N/A | N/A | OmniPath |