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GENE：DOCK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DOCK1
FullNmae dedicator of cytokinesis 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2987
EnsembleID ENSG00000150760
Uniprot Q14185

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DOCK1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DOCK1 GO:0005085,GO:0005085,GO:0005096,GO:0005515,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0006911,GO:0006915,GO:0007165,GO:0007229,GO:0007264,GO:0007520,GO:0010634,GO:0016477,GO:0016607,GO:0017124,GO:0031267,GO:0032045,GO:1900026

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DOCK1 hsa:1793 path:hsa04148 Efferocytosis - Homo sapiens (human)
DOCK1 hsa:1793 path:hsa04510 Focal adhesion - Homo sapiens (human)
DOCK1 hsa:1793 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
DOCK1 hsa:1793 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
DOCK1 hsa:1793 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
DOCK1 hsa:1793 path:hsa05131 Shigellosis - Homo sapiens (human)
DOCK1 hsa:1793 path:hsa05135 Yersinia infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PXN DOCK1 11146654 12432077 14697347 15308668 16000375 18287025 22043013 26192618 29021139 9808620 association N/A ACSN
BCAR1 DOCK1 11146654 12094222 12432077 14697347 15308668 16000375 16076871 18835194 22464172 26192618 9808620 interaction type N/A ACSN
CRK DOCK1 11146654 12094222 12432077 14697347 15308668 15673687 16000375 16076871 18835194 22464172 23180781 26192618 9808620 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
ITGAV DOCK1 10837075 11146654 14697347 15031725 18353785 22035837 22470492 26192618 9295024 9763615 interaction type N/A ACSN
ITGB5 DOCK1 10837075 11146654 14697347 15031725 18353785 22035837 22470492 26192618 9295024 9763615 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
AR DOCK1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 DOCK1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 DOCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DOCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DOCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DOCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DOCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 DOCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DOCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DOCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 DOCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 DOCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 DOCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 DOCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PTTG1 DOCK1 22081074 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001C3AC1 DOCK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000345DEB DOCK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000338542 DOCK1 24604078 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,immunocytochemistry,miRNA interference luciferase reporter assay TarBase
URS00001CF056 DOCK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000001EB3 DOCK1 25416803 26946516 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
NCK2 DOCK1 11240126 14525934 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
ARL4A DOCK1 25348397 N/A physical interaction ComPPI
SNW1 DOCK1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP1LC3B DOCK1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAC1 DOCK1 12134158 14525934 15247908 15723800 24234451 25348397 9808620 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CRK DOCK1 11369773 14525934 17474147 24234451 25348397 8657152 physical association experimental interaction detection,peptide array,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RHOG DOCK1 12879077 14525934 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SRC DOCK1 17474147 24234451 25348397 physical association peptide array,physical interaction ComPPI,IntAct
CRKL DOCK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCK1 DOCK1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
GRB2 DOCK1 17474147 20936779 21706016 24234451 25348397 association,physical association anti tag coimmunoprecipitation,peptide array,physical interaction,two hybrid pooling approach ComPPI,IntAct
PRKACA DOCK1 25348397 N/A physical interaction ComPPI
NTRK1 DOCK1 25348397 N/A physical interaction ComPPI
BTRC DOCK1 25348397 N/A physical interaction ComPPI
HNRNPL DOCK1 25348397 N/A physical interaction ComPPI
DOCK1 ELMO2 25348397 N/A two hybrid,in vitro ComPPI
DOCK1 ELMO1 12134158 14525934 15247908 15723800 18768751 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
DOCK1 BCAR1 12615911 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
DOCK1 PTK2 25348397 N/A physical interaction ComPPI
DOCK1 MEPCE 25348397 N/A physical interaction ComPPI
DOCK1 CUL1 25348397 N/A physical interaction ComPPI
DOCK1 FBXW11 25348397 N/A physical interaction ComPPI
DOCK1 ELMO3 25348397 N/A physical interaction ComPPI
DOCK1 RAC2 25348397 N/A physical interaction ComPPI
DOCK1 FYN 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
DOCK1 ANKRD28 19118547 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
DOCK1 CEBPE 19118547 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
WASF2 DOCK1 11773052 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
DOCK1 DOCK1 15723800 24234451 physical association anti tag coimmunoprecipitation IntAct
CRK DOCK1 10559471 11369773 12615911 15673687 17474147 26344197 27898060 8657152 8662907 stimulant N/A OmniPath
DOCK1 CRK 10559471 11369773 12615911 15673687 17474147 26344197 27898060 8657152 8662907 N/A N/A OmniPath

Visualization










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