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GENE：NOTCH2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NOTCH2
FullNmae notch receptor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7882
EnsembleID ENSG00000134250
Uniprot Q04721

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NOTCH2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NOTCH2 ferroptosis 39121977 Upregulation of miR-425-5p reverses NOTCH2-mediated inhibition of ferroptosis, thereby mitigating gemcitabine resistance. retulator signature

Go Annotation:

GeneSymbol Go id
NOTCH2 GO:0000122,GO:0000139,GO:0001701,GO:0001709,GO:0001947,GO:0002011,GO:0002315,GO:0002437,GO:0003162,GO:0003184,GO:0005509,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005654,GO:0005789,GO:0005886,GO:0005886,GO:0005886,GO:0005929,GO:0006915,GO:0006959,GO:0007219,GO:0007219,GO:0007399,GO:0007411,GO:0009887,GO:0009986,GO:0009986,GO:0010629,GO:0010838,GO:0016020,GO:0019899,GO:0030097,GO:0030326,GO:0030509,GO:0030513,GO:0035264,GO:0035556,GO:0035622,GO:0038023,GO:0042060,GO:0042742,GO:0043011,GO:0043065,GO:0043066,GO:0043235,GO:0043235,GO:0045672,GO:0046579,GO:0046849,GO:0051059,GO:0060413,GO:0060674,GO:0061073,GO:0061314,GO:0070374,GO:0070986,GO:0071228,GO:0072014,GO:0072015,GO:0072104,GO:0072574,GO:1990705,GO:2001204

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NOTCH2 hsa:4853 path:hsa01522 Endocrine resistance - Homo sapiens (human)
NOTCH2 hsa:4853 path:hsa04330 Notch signaling pathway - Homo sapiens (human)
NOTCH2 hsa:4853 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
NOTCH2 hsa:4853 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
NOTCH2 hsa:4853 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
NOTCH2 hsa:4853 path:hsa05200 Pathways in cancer - Homo sapiens (human)
NOTCH2 hsa:4853 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
NOTCH2 hsa:4853 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
NOTCH2 hsa:4853 path:hsa05224 Breast cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NOTCH2 HIF1AN 23180781 24145445 physical association anti tag coimmunoprecipitation InnateDB
ADAM10 NOTCH2 10423016 23331499 stimulation N/A SignaLink,SignaLink
JAG1 NOTCH2 10551863 10958687 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
JAG2 NOTCH2 10958687 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
NOTCH2 DLL1 22390640 interaction type,stimulation N/A SignaLink
NOTCH2 RBPJ 23331499 9032325 stimulation N/A SignaLink
LTC4S NOTCH2 11101851 23331499 stimulation N/A SignaLink
DLL3 NOTCH2 11823422 23331499 stimulation N/A SignaLink
MAML2 NOTCH2 12370315 23331499 stimulation N/A SignaLink
MAML3 NOTCH2 12370315 23331499 stimulation N/A SignaLink
MDK NOTCH2 18469519 23331499 stimulation N/A SignaLink
LFNG NOTCH2 10934472 11346656 23331499 interaction type N/A SignaLink
MFNG NOTCH2 11346656 23331499 interaction type N/A SignaLink
GALM NOTCH2 11346656 23331499 inhibition N/A SignaLink
DLK1 NOTCH2 18700817 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
CNTN1 NOTCH2 20005715 interaction type N/A PSP
DTX1 NOTCH2 20005715 interaction type N/A PSP
JAG2 NOTCH2 20005715 interaction type N/A PSP
DTX1 NOTCH2 18988627 20005715 9244302 N/A N/A SignaLink
JAG2 NOTCH2 20005715 N/A N/A SignaLink
CNTN1 NOTCH2 14567914 14567914 18988627 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR NOTCH2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 NOTCH2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 NOTCH2 19376833 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ESR2 NOTCH2 19376833 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 NOTCH2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C NOTCH2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 NOTCH2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 NOTCH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NOTCH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NOTCH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NOTCH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NOTCH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 NOTCH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NOTCH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NOTCH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 NOTCH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NOTCH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 NOTCH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000008F0CF NOTCH2 23299462 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000018C928 NOTCH2 20080834 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000A939F NOTCH2 19955368 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00000EED18 NOTCH2 19773441 22363487 rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunocytochemistry,miRNA interference luciferase reporter assay miRSponge
URS000018C928 NOTCH2 20080834 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000A939F NOTCH2 19955368 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00000EED18 NOTCH2 19773441 22363487 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunocytochemistry,miRNA interference luciferase reporter assay TarBase
URS000008F0CF NOTCH2 23220650 23299462 23572380 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000338542 NOTCH2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000345DEB NOTCH2 20371350 23824327 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00000EC1BE NOTCH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002C0FCB NOTCH2 19536157 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS0000330617 NOTCH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000039E1E1 NOTCH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 NOTCH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA NOTCH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 NOTCH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CC379 NOTCH2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000018CD09 NOTCH2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000183BED NOTCH2 25416803 26041881 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000016914 NOTCH2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000016FF9C NOTCH2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001D4A78 NOTCH2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 NOTCH2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A NOTCH2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 NOTCH2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D NOTCH2 22473208 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C NOTCH2 22473208 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 NOTCH2 22473208 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001123BD NOTCH2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000019F055 NOTCH2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 NOTCH2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000079F78 NOTCH2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000055128B NOTCH2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000077DDE NOTCH2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000057A7C NOTCH2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B NOTCH2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004AC389 NOTCH2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFBE3 NOTCH2 25416803 26165719 27832663 28278511 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002B2B5C NOTCH2 25416803 25992613 mrna cleavage,inhibition array technology,experimental interaction detection,nucleotide sequence identification,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
VASN NOTCH2 25348397 N/A physical interaction ComPPI
CDC42 NOTCH2 25348397 N/A physical interaction ComPPI
LRATD2 NOTCH2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RABGGTB NOTCH2 25348397 N/A physical interaction ComPPI
EGLN3 NOTCH2 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
SMAD1 NOTCH2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CRKL NOTCH2 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAML1 NOTCH2 11101851 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
NOTCH1 NOTCH2 23022380 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
DLL1 NOTCH2 10958687 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GSK3B NOTCH2 12794074 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PDIA6 NOTCH2 25348397 N/A physical interaction ComPPI
CDH1 NOTCH2 25348397 N/A physical interaction ComPPI
PLAUR NOTCH2 25348397 N/A physical interaction ComPPI
CNTN1 NOTCH2 14525934 14567914 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SIN3A NOTCH2 25348397 N/A physical interaction ComPPI
HNRNPL NOTCH2 25348397 N/A physical interaction ComPPI
RDX NOTCH2 25348397 N/A physical interaction ComPPI
PSMC3IP NOTCH2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PSEN2 NOTCH2 11518718 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
JAG2 NOTCH2 10958687 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LFNG NOTCH2 11346656 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MFNG NOTCH2 11346656 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
DTX1 NOTCH2 14525934 25348397 9244302 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAML2 NOTCH2 12370315 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAML3 NOTCH2 12370315 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MTA3 NOTCH2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ST14 NOTCH2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MSN NOTCH2 25348397 N/A physical interaction ComPPI
HIF1AN NOTCH2 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
ATP2A2 NOTCH2 25348397 N/A physical interaction ComPPI
SPEN NOTCH2 25348397 N/A physical interaction ComPPI
PCMT1 NOTCH2 25348397 N/A physical interaction ComPPI
NOTCH2 PSEN1 11518718 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NOTCH2 MYOC 14525934 16289162 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
NOTCH2 RBPJ 14525934 24234451 25348397 25609649 26496610 9032325 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
NOTCH2 JAG1 10551863 10958687 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
NOTCH2 NDUFV2 25348397 N/A physical interaction ComPPI
NOTCH2 NDUFV1 25348397 N/A physical interaction ComPPI
NOTCH2 SEC24C 25348397 N/A physical interaction ComPPI
NOTCH2 TJP1 25348397 N/A physical interaction ComPPI
NOTCH2 EGFL7 25348397 N/A physical interaction ComPPI
NOTCH2 ANKRD28 23414517 24234451 24255178 25348397 colocalization,physical association physical interaction,two hybrid fragment pooling approach,proximity-dependent biotin identification ComPPI,IntAct
NOTCH2 LATS2 25348397 N/A physical interaction ComPPI
NOTCH2 ASB14 25348397 N/A physical interaction ComPPI
NOTCH2 ANKRD44 25348397 N/A physical interaction ComPPI
NOTCH2 ZFP41 25348397 N/A physical interaction ComPPI
NOTCH2 EEF2 25348397 N/A physical interaction ComPPI
NOTCH2 AFDN 25348397 N/A physical interaction ComPPI
NOTCH2 CST6 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NOTCH2 EPSTI1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NOTCH2 IL13RA2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NOTCH2 IL24 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NOTCH2 ITIH5 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NOTCH2 KLK5 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NOTCH2 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NOTCH2 FBXL17 25348397 N/A physical interaction ComPPI
NOTCH2 LRRIQ1 25348397 N/A physical interaction ComPPI
NOTCH2 AGRP 25348397 N/A physical interaction ComPPI
NOTCH2 GOLM1 24234451 25348397 27569582 association anti tag coimmunoprecipitation ComPPI,IntAct
NOTCH2 BET1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NOTCH2 EZR 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NOTCH2 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NOTCH2 TGOLN2 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
PSMB1 NOTCH2 25348397 N/A physical interaction ComPPI
HSCB NOTCH2 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
CCR2 NOTCH2 24234451 28298427 physical association ubiquitin reconstruction IntAct
NOTCH2 TCF3 27898060 9528794 inhibition N/A OmniPath
JAG2 NOTCH2 10958687 27898060 inhibition,stimulant N/A OmniPath
MAML1 NOTCH2 11101851 27898060 stimulant N/A OmniPath
NOTCH2 RBPJ 25609649 26186194 26496610 27898060 9032325 stimulant N/A OmniPath
DLL1 NOTCH2 10958687 11346656 23111325 27898060 9244302 stimulant N/A OmniPath
LFNG NOTCH2 10934472 11346656 1134666 27898060 inhibition,stimulant N/A OmniPath
JAG1 NOTCH2 10551863 10958687 1095869 11346656 18660822 27898060 inhibition,stimulant N/A OmniPath
GSK3B NOTCH2 12794074 15302935 18669648 20068231 27898060 inhibition,stimulant N/A OmniPath
ADAM10 NOTCH2 10423016 27898060 stimulant N/A OmniPath
MDK NOTCH2 18469519 27898060 stimulant N/A OmniPath
DLL4 NOTCH2 22842086 27898060 stimulant N/A OmniPath
MAML3 NOTCH2 12370315 27898060 stimulant N/A OmniPath
DLL3 NOTCH2 11823422 27898060 stimulant N/A OmniPath
MAML2 NOTCH2 12370315 27898060 stimulant N/A OmniPath
DLK1 NOTCH2 18700817 27898060 stimulant N/A OmniPath
GXYLT1 NOTCH2 22117070 27898060 stimulant N/A OmniPath
MFNG NOTCH2 11346656 27898060 stimulant N/A OmniPath
GXYLT2 NOTCH2 22117070 27898060 stimulant N/A OmniPath
POGLUT1 NOTCH2 22872643 27898060 stimulant N/A OmniPath

Visualization










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