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GENE：PEA15

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PEA15
FullNmae proliferation and apoptosis adaptor protein 15
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8822
EnsembleID ENSG00000162734
Uniprot Q15121

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PEA15 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PEA15 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PEA15 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PEA15 GO:0000165,GO:0005515,GO:0005654,GO:0005829,GO:0005829,GO:0005875,GO:0006915,GO:0008643,GO:0043231,GO:0046325,GO:1902042,GO:1902042,GO:1902043

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AKT1 PEA15 12808093 23180781 phosphorylation reaction,physical association pull down,in-gel kinase assay InnateDB
MAPK1 PEA15 11702783 23180781 physical association two hybrid InnateDB
MAPK3 PEA15 11702783 18077417 23180781 23331499 interaction type,physical association two hybrid InnateDB,SignaLink
PEA15 MAPK3 11702783 21900206 23331499 stimulation N/A SignaLink
PEA15 MAPK1 11702783 14506247 17255949 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR PEA15 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 PEA15 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PEA15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PEA15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX3 PEA15 17956589 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001AFC71 PEA15 20388802 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000EED18 PEA15 20388802 rna interference,inhibition western blot miRSponge
URS00001AFC71 PEA15 20388802 22743998 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS00000EED18 PEA15 20371350 20388802 22815788 25416803 mrna cleavage,inhibition array technology,nucleotide sequence identification,western blot,quantitative reverse transcription pcr TarBase
URS00003380CC PEA15 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D PEA15 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000338542 PEA15 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS00001067D1 PEA15 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000011DF PEA15 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA PEA15 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075E2C3 PEA15 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000077AED PEA15 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000482389 PEA15 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000435A77 PEA15 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000041E780 PEA15 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000299AD8 PEA15 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA PEA15 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 PEA15 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 PEA15 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 PEA15 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F PEA15 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA PEA15 19536157 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000600E6 PEA15 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 PEA15 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B PEA15 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000008F0CF PEA15 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 PEA15 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000D5FFC PEA15 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000134ADC PEA15 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000171020 PEA15 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007F792 PEA15 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000008B558 PEA15 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000BE495 PEA15 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000032D69B PEA15 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000076E54 PEA15 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002B0B46 PEA15 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000202460 PEA15 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D15B PEA15 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000036AFF1 PEA15 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E728C PEA15 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
AKT1 PEA15 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PLD1 PEA15 25361965 interaction type N/A PTMCode2
PEA15 PLD1 25361965 interaction type N/A PTMCode2
MAPK1 PEA15 25361965 interaction type N/A PTMCode2
PEA15 MAPK1 25361965 interaction type N/A PTMCode2
PEA15 AKT1 25361965 interaction type N/A PTMCode2
CAMK2B PEA15 25361965 interaction type N/A PTMCode2
PEA15 CAMK2B 25361965 interaction type N/A PTMCode2
PEA15 RPS6KA2 25361965 interaction type N/A PTMCode2
RPS6KA2 PEA15 25361965 interaction type N/A PTMCode2
FADD PEA15 25361965 interaction type N/A PTMCode2
PEA15 FADD 25361965 interaction type N/A PTMCode2
CASP8 PEA15 25361965 interaction type N/A PTMCode2
PEA15 CASP8 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAPK1 PEA15 11702783 14525934 17255949 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
PRKCA PEA15 14525934 25348397 9721757 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPK3 PEA15 11702783 14525934 21900206 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
PLD2 PEA15 10926929 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PDPK1 PEA15 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
L1CAM PEA15 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CASP8 PEA15 10442631 10493725 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HNRNPL PEA15 25348397 N/A physical interaction ComPPI
RPS6KA3 PEA15 12796492 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PEA15 CAMK2G 25348397 N/A in vitro,in vivo ComPPI
PEA15 FADD 10442631 10493725 14525934 22179576 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
PEA15 HTRA2 14525934 15328349 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PEA15 ABCD4 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PEA15 PANK4 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PEA15 AK9 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PEA15 LUC7L2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PEA15 AKT1 12808093 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PEA15 PLD1 10926929 14525934 18541525 25348397 27898060 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
PEA15 TERF2IP 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
PEA15 IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PEA15 LGR4 25348397 N/A physical interaction ComPPI
PEA15 CEP170 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PEA15 FBF1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PEA15 STIL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
BCAT2 PEA15 24234451 30021884 physical association cross-linking study IntAct
SMYD5 PEA15 24234451 30021884 physical association cross-linking study IntAct
PRKCA PEA15 15917297 17287340 19651622 20068231 27898060 9721757 inhibition N/A OmniPath
AKT1 PEA15 12808093 17227770 17287340 17700518 18212344 18452278 18578522 18669648 18767875 19413330 19651622 19664995 20068231 20166139 20452983 21285289 25416196 27898060 9721757 stimulant N/A OmniPath
MAPK3 PEA15 11702783 21900206 2190021 27898060 N/A N/A OmniPath
PEA15 MAPK3 11702783 21900206 2190021 27898060 stimulant N/A OmniPath
MAPK14 PEA15 12808093 27898060 9721757 N/A N/A OmniPath
MAPK1 PEA15 11702783 14506247 17255949 27898060 N/A N/A OmniPath
PEA15 MAPK1 11702783 14506247 17255949 27898060 inhibition,stimulant N/A OmniPath
CAMK2A PEA15 15916534 27898060 stimulant N/A OmniPath
HTRA2 PEA15 15328349 27898060 inhibition N/A OmniPath
CAMK2G PEA15 12808093 17287340 18212344 18452278 18578522 18669648 18767875 19413330 19651622 19664995 20068231 20166139 27898060 9721757 N/A N/A OmniPath

Visualization










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