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GENE：SENP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SENP2
FullNmae SUMO specific peptidase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:23116
EnsembleID ENSG00000163904
Uniprot Q9HC62

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SENP2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SENP2 ferroptosis 40366738 Deletion of SENP2 increased cardiomyocyte ferroptosis and hindered cardiac function recovery after MI/R injury, whereas overexpression of SENP2 significantly reduced cardiomyocyte ferroptosis and mitigated MI/R injury. retulator signature

Go Annotation:

GeneSymbol Go id
SENP2 GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005829,GO:0015031,GO:0016055,GO:0016605,GO:0016925,GO:0016926,GO:0016926,GO:0016926,GO:0016929,GO:0030111,GO:0031397,GO:0031398,GO:0031648,GO:0031965,GO:0045444,GO:0051028,GO:0070139,GO:0070139

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SENP2 hsa:59343 path:hsa03013 Nucleocytoplasmic transport - Homo sapiens (human)
SENP2 hsa:59343 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IKBKG SENP2 20098747 23180781 physical association protein array,pull down InnateDB
APP SENP2 21832049 23180781 physical association protein array InnateDB
SENP2 ELAVL1 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR SENP2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SENP2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SENP2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 SENP2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF SENP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SENP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SENP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
IGF1R SENP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 SENP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 SENP2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000005CF5F SENP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000060AABB SENP2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000009EA8F SENP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001C770D SENP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000192A75 SENP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000519450 SENP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002394F5 SENP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005F1B8C SENP2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 SENP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004E02F2 SENP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000BD6DC SENP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C403E SENP2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000020579D SENP2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000004BACE SENP2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000015A0D9 SENP2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00001ADE63 SENP2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00002578DA SENP2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00005485E8 SENP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000047A8F SENP2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000077DDE SENP2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000ECE9C SENP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000214763 SENP2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00005DEC41 SENP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000001A7A SENP2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000EC1BE SENP2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00002E728C SENP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002367FA SENP2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CHEK1 SENP2 22135298 phosphorylation N/A PhosphoSite
RPS6KA1 SENP2 22135298 phosphorylation N/A PhosphoSite
NUP153 SENP2 25361965 interaction type N/A PTMCode2
SENP2 NUP153 25361965 interaction type N/A PTMCode2
AXIN1 SENP2 25361965 interaction type N/A PTMCode2
SENP2 AXIN1 25361965 interaction type N/A PTMCode2
SENP2 SUMO2 25361965 interaction type N/A PTMCode2
SUMO2 SENP2 25361965 interaction type N/A PTMCode2
SENP2 SUMO1 25361965 interaction type N/A PTMCode2
SUMO1 SENP2 25361965 interaction type N/A PTMCode2
PML SENP2 25361965 interaction type N/A PTMCode2
SENP2 PML 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPK SENP2 23092970 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DAXX SENP2 25348397 N/A physical interaction ComPPI
KPNA1 SENP2 25348397 N/A physical interaction ComPPI
LMNA SENP2 25348397 N/A physical interaction ComPPI
FUNDC1 SENP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KASH5 SENP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RPRM SENP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SMAD2 SENP2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
SUMO1 SENP2 11997515 12192048 14525934 14673145 15296745 15896780 17099700 24234451 25348397 27898060 N/A experimental interaction detection,x-ray crystallography,physical interaction,enzymatic study,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
FZR1 SENP2 25348397 25483061 27898060 N/A physical interaction ComPPI,OmniPath
KPNB1 SENP2 25348397 N/A physical interaction ComPPI
CANX SENP2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AXIN1 SENP2 11997515 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MYC SENP2 25348397 N/A physical interaction ComPPI
AGTRAP SENP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NEDD4L SENP2 25348397 N/A physical interaction ComPPI
SUMO2 SENP2 17099700 24234451 25348397 25416956 physical association x-ray crystallography,physical interaction,two hybrid array,enzymatic study,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SUMO3 SENP2 11997515 14525934 17099700 24234451 25348397 25416956 physical association anti tag coimmunoprecipitation,experimental interaction detection,x-ray crystallography,physical interaction,two hybrid array,enzymatic study,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
RANGAP1 SENP2 17099700 24234451 25348397 physical association molecular sieving,x-ray crystallography,physical interaction,enzymatic study ComPPI,IntAct
TRIM63 SENP2 25348397 N/A physical interaction ComPPI
HIPK2 SENP2 25348397 N/A physical interaction ComPPI
BCOR SENP2 25348397 N/A physical interaction ComPPI
NUP153 SENP2 11896061 12192048 14525934 24234451 25348397 26496610 27898060 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct,OmniPath
ELAVL1 SENP2 25348397 N/A physical interaction ComPPI
ARL6IP1 SENP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NUP133 SENP2 25348397 N/A physical interaction ComPPI
PML SENP2 12419228 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
SENP2 CDK5RAP2 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SENP2 IKBKG 20098747 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct
SENP2 APP 25348397 N/A physical interaction ComPPI
SENP2 TPD52 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SENP2 CDCA5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SENP2 SYNE4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SENP2 TMEM239 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SENP2 NUP43 25348397 N/A physical interaction ComPPI
SENP2 NUP107 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SENP2 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SENP2 TMEM216 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SENP2 NACC1 25348397 N/A physical interaction ComPPI
SENP2 CTDNEP1 25348397 N/A physical interaction ComPPI
SENP2 USP28 25348397 N/A physical interaction ComPPI
SENP2 PGK2 25348397 N/A physical interaction ComPPI
SENP2 USP25 25348397 N/A physical interaction ComPPI
SENP2 HCCS 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SENP2 ACSF2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SENP2 RETREG3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SENP2 SDR16C5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SENP2 TNFRSF10D 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SENP2 APOC4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CCT6A SENP2 24234451 30021884 physical association cross-linking study IntAct
RPS6KA1 SENP2 25689261 27898060 N/A N/A OmniPath
IKBKG SENP2 20098747 21777808 27898060 N/A N/A OmniPath

Visualization










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