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GENE：WNK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol WNK1
FullNmae WNK lysine deficient protein kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14540
EnsembleID ENSG00000060237
Uniprot Q9H4A3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
WNK1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
WNK1 GO:0002028,GO:0003084,GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0006468,GO:0006468,GO:0006811,GO:0006884,GO:0007165,GO:0007507,GO:0010507,GO:0010793,GO:0010820,GO:0016020,GO:0018105,GO:0018107,GO:0018107,GO:0018107,GO:0019901,GO:0019902,GO:0030295,GO:0030644,GO:0031397,GO:0032991,GO:0033633,GO:0034115,GO:0034260,GO:0035556,GO:0035556,GO:0035725,GO:0038116,GO:0043232,GO:0045050,GO:0045766,GO:0048666,GO:0050852,GO:0055075,GO:0055080,GO:0071474,GO:0072686,GO:0090188,GO:0090263,GO:0097022,GO:0106310,GO:0140693,GO:0140694,GO:1902305,GO:1903038,GO:1903077,GO:1903490,GO:1904062,GO:1904595,GO:1990869

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
YWHAG WNK1 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR WNK1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 WNK1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP73 WNK1 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 WNK1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 WNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000B59A2 WNK1 20813867 rna interference,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000F31F4 WNK1 20813867 rna interference,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000B59A2 WNK1 20813867 25416803 mrna cleavage,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000F31F4 WNK1 20813867 25416803 mrna cleavage,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000009262D WNK1 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D WNK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000600E6 WNK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 WNK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 WNK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000035CC3E WNK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 WNK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 WNK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC WNK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000451A1 WNK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD WNK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 WNK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D WNK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000345DEB WNK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F4AC3 WNK1 23622248 25416803 28178938 mrna cleavage,inhibition quantitative reverse transcription pcr,clash TarBase
URS0000324096 WNK1 20371350 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00002F8148 WNK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 WNK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 WNK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 WNK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001FFA8C WNK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 WNK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004AF715 WNK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F WNK1 22473208 22815788 25416803 26378023 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000330617 WNK1 22473208 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,clip TarBase
URS0000338542 WNK1 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS00000D2680 WNK1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE WNK1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 WNK1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 WNK1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000101787 WNK1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002C28B2 WNK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000016E46F WNK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001C04A2 WNK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 WNK1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 WNK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 WNK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000366551 WNK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000272A92 WNK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB WNK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000334286 WNK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005F305A WNK1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000049704B WNK1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A WNK1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 WNK1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000DD591 WNK1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001D69F6 WNK1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000004203C WNK1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000572E11 WNK1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000028D811 WNK1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004AE8D3 WNK1 24469051 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000003E1A9 WNK1 25416803 26378023 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002D0FC3 WNK1 25416803 26378023 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
WNK2 WNK1 22135298 phosphorylation N/A PhosphoSite
WNK3 WNK1 22135298 phosphorylation N/A PhosphoSite
SGK1 WNK1 22135298 phosphorylation N/A PhosphoSite
MTOR WNK1 22135298 phosphorylation N/A PhosphoSite
WNK1 OXSR1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
WNK1 WNK1 22135298 phosphorylation N/A PhosphoSite
WNK1 SLC12A6 22135298 phosphorylation N/A PhosphoSite
WNK1 STK39 22135298 phosphorylation N/A PhosphoSite
RPS6KA5 WNK1 22135298 phosphorylation N/A PhosphoSite
AKT1 WNK1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
WNK1 MAP3K2 25361965 interaction type N/A PTMCode2
MAP3K2 WNK1 25361965 interaction type N/A PTMCode2
WNK1 MAP3K3 25361965 interaction type N/A PTMCode2
MAP3K3 WNK1 25361965 interaction type N/A PTMCode2
WNK1 SYT2 25361965 interaction type N/A PTMCode2
SYT2 WNK1 25361965 interaction type N/A PTMCode2
OXSR1 WNK1 25361965 interaction type N/A PTMCode2
WNK1 AKT1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I WNK1 25348397 N/A physical interaction ComPPI
LCP2 WNK1 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
FHL3 WNK1 25348397 N/A physical interaction ComPPI
HSPA8 WNK1 24234451 25348397 29568061 association pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CDC42 WNK1 25348397 N/A physical interaction ComPPI
CIAO2B WNK1 25348397 N/A physical interaction ComPPI
OXSR1 WNK1 16832045 17721439 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,two hybrid,pull down,phosphorylation reaction,physical interaction,protein kinase assay ComPPI,IntAct
BAG3 WNK1 25348397 N/A physical interaction ComPPI
TNFAIP3 WNK1 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
EIF2B2 WNK1 25348397 N/A physical interaction ComPPI
VCP WNK1 25348397 N/A physical interaction ComPPI
FAM53C WNK1 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
YWHAG WNK1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vivo ComPPI,IntAct
ATXN1 WNK1 16713569 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BAD WNK1 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ZYX WNK1 25348397 N/A physical interaction ComPPI
ARAF WNK1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
COPS5 WNK1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
KLHL3 WNK1 25348397 N/A physical interaction ComPPI
FLNC WNK1 25348397 N/A physical interaction ComPPI
SLC9A1 WNK1 25348397 N/A physical interaction ComPPI
YWHAB WNK1 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAZ WNK1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PRKAR1A WNK1 25348397 N/A physical interaction ComPPI
PFKP WNK1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PICALM WNK1 25348397 N/A physical interaction ComPPI
SERPINB13 WNK1 25348397 N/A physical interaction ComPPI
PVR WNK1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FHOD1 WNK1 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CHAF1A WNK1 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PPP1CA WNK1 19389623 24234451 25348397 physical association far western blotting,pull down ComPPI,IntAct
MAP2K1 WNK1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PLEC WNK1 24234451 25348397 30021884 physical association cross-linking study,physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PRKAR1B WNK1 25348397 N/A physical interaction ComPPI
RANBP9 WNK1 25348397 N/A physical interaction ComPPI
RAPGEF5 WNK1 25348397 N/A physical interaction ComPPI
XPO1 WNK1 25348397 N/A physical interaction ComPPI
YWHAQ WNK1 25348397 N/A physical interaction ComPPI
CLTC WNK1 25348397 N/A physical interaction ComPPI
UPF2 WNK1 25348397 N/A physical interaction ComPPI
NEDD4L WNK1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
EPB41L2 WNK1 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ADRB2 WNK1 25348397 N/A physical interaction ComPPI
YWHAE WNK1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MMS19 WNK1 25348397 N/A physical interaction ComPPI
OCRL WNK1 24234451 25107275 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CENPJ WNK1 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MADD WNK1 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
BAG4 WNK1 25348397 N/A physical interaction ComPPI
WNK1 SYT2 25348397 N/A in vivo ComPPI
WNK1 AKT1 25348397 N/A in vitro,in vivo ComPPI
WNK1 MAP3K3 25348397 N/A in vitro,in vivo ComPPI
WNK1 MAP3K2 25348397 N/A in vitro,in vivo ComPPI
WNK1 E2F3 25348397 N/A physical interaction ComPPI
WNK1 MT-ATP8 25348397 N/A physical interaction ComPPI
WNK1 CSDE1 25348397 N/A physical interaction ComPPI
WNK1 TSC22D1 25348397 N/A physical interaction ComPPI
WNK1 TNRC6A 25348397 N/A physical interaction ComPPI
WNK1 ZNF106 25348397 N/A physical interaction ComPPI
WNK1 WNK2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 GLIS2 17289029 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 SGK1 25348397 N/A physical interaction ComPPI
WNK1 KLHL2 25348397 N/A physical interaction ComPPI
WNK1 EIF3K 25348397 N/A physical interaction ComPPI
WNK1 HNRNPD 25348397 N/A physical interaction ComPPI
WNK1 METTL6 25348397 N/A physical interaction ComPPI
WNK1 TSC22D4 25348397 N/A physical interaction ComPPI
WNK1 AAMP 25348397 N/A physical interaction ComPPI
WNK1 MED4 25348397 N/A physical interaction ComPPI
WNK1 CLTB 25348397 N/A physical interaction ComPPI
WNK1 GAK 25348397 N/A physical interaction ComPPI
WNK1 GTSE1 25348397 N/A physical interaction ComPPI
WNK1 SPATA1 25348397 N/A physical interaction ComPPI
WNK1 AARSD1 25348397 N/A physical interaction ComPPI
WNK1 HAO2 25348397 N/A physical interaction ComPPI
WNK1 STAMBPL1 25348397 N/A physical interaction ComPPI
WNK1 MLF1 25348397 N/A physical interaction ComPPI
WNK1 AAK1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
WNK1 TRIM25 25348397 N/A physical interaction ComPPI
WNK1 ME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
WNK1 ZNF839 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 FAM13B 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 RIPOR2 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 CGNL1 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 EIF3A 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 RMDN3 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 HDAC9 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 HIVEP2 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 KIAA0232 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 IRAG2 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 MPHOSPH9 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 MYH9 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 MSL2 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 ITPRID2 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 SYNPO 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 SYNPO2 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 TNS1 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 WWTR1 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 RAP1GAP2 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 SIMC1 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 RASAL3 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
WNK1 TULP3 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
HSCB WNK1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
WNK1 WNK1 20936779 24234451 physical association two hybrid pooling approach IntAct
HMGN2 WNK1 24234451 30021884 physical association cross-linking study IntAct
AKT1 WNK1 14611643 16081417 27898060 stimulant N/A OmniPath
AURKA WNK1 14611643 27898060 N/A N/A OmniPath
SGK1 WNK1 14611643 16006511 16081417 20525693 22119528 27898060 N/A N/A OmniPath
WNK1 NEDD4L 15328345 18669648 18691976 20525693 20936779 26241057 27898060 N/A N/A OmniPath
WNK1 STK39 16083423 17190791 18270262 27898060 stimulant N/A OmniPath
WNK1 OXSR1 16083423 17190791 17721439 24191005 25389294 27898060 stimulant N/A OmniPath
WNK1 SLC12A6 19665974 27898060 inhibition N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008BE56C WNK1 27087310 direct interaction,inhibition N/A NPInter

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