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GENE：XRCC4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol XRCC4
FullNmae X-ray repair cross complementing 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12831
EnsembleID ENSG00000152422
Uniprot Q13426

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
XRCC4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
XRCC4 GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005829,GO:0005958,GO:0005958,GO:0006302,GO:0006303,GO:0006303,GO:0006303,GO:0006303,GO:0010165,GO:0010165,GO:0032807,GO:0032807,GO:0033152,GO:0035861,GO:0042802,GO:0051103,GO:0051103,GO:0051351,GO:0051351,GO:0070419,GO:0070975,GO:1990166

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
XRCC4 hsa:7518 path:hsa03450 Non-homologous end-joining - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 XRCC4 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 XRCC4 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 XRCC4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 XRCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA XRCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF XRCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 XRCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 XRCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS XRCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 XRCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A XRCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 XRCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
CSNK2A1 XRCC4 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKDC XRCC4 22135298 phosphorylation N/A PhosphoSite
XRCC4 NHEJ1 25361965 interaction type N/A PTMCode2
NHEJ1 XRCC4 25361965 interaction type N/A PTMCode2
XRCC4 LIG4 25361965 interaction type N/A PTMCode2
LIG4 XRCC4 25361965 interaction type N/A PTMCode2
XRCC4 CSNK2A1 25361965 interaction type N/A PTMCode2
APLF XRCC4 25361965 interaction type N/A PTMCode2
XRCC4 APLF 25361965 interaction type N/A PTMCode2
NBN XRCC4 25361965 interaction type N/A PTMCode2
XRCC4 NBN 25361965 interaction type N/A PTMCode2
PNKP XRCC4 25361965 interaction type N/A PTMCode2
XRCC4 PNKP 25361965 interaction type N/A PTMCode2
BIN1 XRCC4 25361965 interaction type N/A PTMCode2
XRCC4 BIN1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NUDT21 XRCC4 25348397 N/A physical interaction ComPPI
VIM XRCC4 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MAGEA6 XRCC4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CALM1 XRCC4 25348397 N/A physical interaction ComPPI
APPBP2 XRCC4 25348397 N/A physical interaction ComPPI
APLF XRCC4 14525934 17353262 17396150 23178593 24234451 25348397 physical association two hybrid,experimental interaction detection,filter binding,pull down,physical interaction ComPPI,HPRD,IntAct
NF2 XRCC4 25348397 N/A physical interaction ComPPI
PRKDC XRCC4 14525934 25348397 9430729 N/A experimental interaction detection,physical interaction ComPPI,HPRD
USP7 XRCC4 25348397 N/A physical interaction ComPPI
PNKP XRCC4 14525934 15385968 17353931 21637298 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,pull down,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,HPRD,IntAct
LIG4 XRCC4 10854421 11702069 14525934 22529269 23219551 24234451 25348397 25416956 25910212 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,light scattering,molecular sieving,pull down,x-ray crystallography,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
NHEJ1 XRCC4 14525934 16439205 17567543 18064046 21349273 24234451 25348397 29997244 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,two hybrid,coimmunoprecipitation,transmission electron microscopy,experimental interaction detection,isothermal titration calorimetry,light scattering,molecular sieving,pull down,x-ray crystallography,physical interaction,two hybrid ComPPI,HPRD,IntAct
ACTN1 XRCC4 14525934 16189514 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APTX XRCC4 14525934 15380105 16439205 16713569 16964241 19442253 24234451 25348397 26186194 27898060 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct,OmniPath
XRCC5 XRCC4 25348397 N/A physical interaction ComPPI
CSNK2A1 XRCC4 14525934 15385968 24234451 25348397 phosphorylation reaction experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
XRCC6 XRCC4 17124166 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cross-linking study,physical interaction ComPPI,IntAct
DDX5 XRCC4 25348397 N/A physical interaction ComPPI
BIN1 XRCC4 14525934 16275660 24234451 25348397 physical association two hybrid,experimental interaction detection,filter binding,peptide array,pull down,physical interaction,two hybrid ComPPI,HPRD,IntAct
NFKB1 XRCC4 25348397 N/A physical interaction ComPPI
NBN XRCC4 25348397 N/A physical interaction ComPPI
GSC2 XRCC4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VPS41 XRCC4 25348397 N/A physical interaction ComPPI
MTMR7 XRCC4 25348397 N/A physical interaction ComPPI
MED4 XRCC4 25348397 N/A physical interaction ComPPI
DCLRE1C XRCC4 22529269 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
FYTTD1 XRCC4 25348397 N/A physical interaction ComPPI
SRP54 XRCC4 25348397 N/A physical interaction ComPPI
DNPEP XRCC4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
IFFO1 XRCC4 14525934 16189514 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SINHCAF XRCC4 25348397 N/A physical interaction ComPPI
ALDH7A1 XRCC4 25348397 N/A physical interaction ComPPI
CAAP1 XRCC4 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
DENR XRCC4 25348397 N/A physical interaction ComPPI
HAUS2 XRCC4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CHD3 XRCC4 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
XRCC4 ERG 25348397 N/A physical interaction ComPPI
XRCC4 CWC27 25348397 N/A physical interaction ComPPI
XRCC4 ASTE1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
XRCC4 FAM9B 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
XRCC4 IFFO2 25348397 N/A physical interaction ComPPI
XRCC4 LONRF2 25348397 N/A physical interaction ComPPI
XRCC4 RNF135 25348397 N/A physical interaction ComPPI
XRCC4 DNAJC9 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
XRCC4 HSDL2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
XRCC4 KIF3A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
XRCC4 KRT27 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SETMAR XRCC4 25348397 N/A physical interaction ComPPI
XRCC4 AHNAK 14525934 15177040 N/A experimental interaction detection HPRD
XRCC4 XRCC4 10854421 14525934 16169070 17567543 21768349 24234451 25416956 9352367 physical association transmission electron microscopy,experimental interaction detection,two hybrid array,two hybrid pooling approach,two hybrid prey pooling approach,two hybrid HPRD,IntAct
GZMB XRCC4 12218164 14525934 N/A experimental interaction detection HPRD
H1-1 XRCC4 24234451 30021884 physical association cross-linking study IntAct
XRCC4 POLL 14561766 27898060 N/A N/A OmniPath
DCLRE1C XRCC4 16857680 27898060 stimulant N/A OmniPath
ABL1 XRCC4 14599745 27898060 N/A N/A OmniPath
SUMO1 XRCC4 16478998 27898060 stimulant N/A OmniPath
CSNK2A1 XRCC4 15385968 20852255 27898060 N/A N/A OmniPath
PRKDC XRCC4 12218164 14599745 15177042 15194694 15520013 22939629 25166505 27898060 9430729 N/A N/A OmniPath
XRCC4 PNKP 12032095 15385968 17353931 21637298 26186194 27898060 stimulant N/A OmniPath

Visualization










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