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GENE：BCAT2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BCAT2
FullNmae branched chain amino acid transaminase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:977
EnsembleID ENSG00000105552
Uniprot O15382

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BCAT2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
BCAT2 GO:0004084,GO:0005654,GO:0005739,GO:0005739,GO:0005759,GO:0006550,GO:0006629,GO:0009082,GO:0009098,GO:0009099,GO:0010817,GO:0050048,GO:0052654,GO:0052655,GO:0052656,GO:1990830

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BCAT2 hsa:587 path:hsa00270 Cysteine and methionine metabolism - Homo sapiens (human)
BCAT2 hsa:587 path:hsa00280 Valine, leucine and isoleucine degradation - Homo sapiens (human)
BCAT2 hsa:587 path:hsa00290 Valine, leucine and isoleucine biosynthesis - Homo sapiens (human)
BCAT2 hsa:587 path:hsa00770 Pantothenate and CoA biosynthesis - Homo sapiens (human)
BCAT2 hsa:587 path:hsa01100 Metabolic pathways - Homo sapiens (human)
BCAT2 hsa:587 path:hsa01210 2-Oxocarboxylic acid metabolism - Homo sapiens (human)
BCAT2 hsa:587 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)
BCAT2 hsa:587 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APP BCAT2 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 BCAT2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 BCAT2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 BCAT2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 BCAT2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF BCAT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 BCAT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BCAT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BCAT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 BCAT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002FC5B0 BCAT2 20371350 22473208 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00003D5391 BCAT2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE BCAT2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A7F58 BCAT2 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PTGDS BCAT2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NIT1 BCAT2 25348397 N/A physical interaction ComPPI
CREB3 BCAT2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TRIM25 BCAT2 25348397 N/A physical interaction ComPPI
CAT BCAT2 25348397 N/A physical interaction ComPPI
HSPD1 BCAT2 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
BCAT2 APP 25348397 N/A physical interaction ComPPI
BCAT2 ALDOA 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCAT2 EEF2KMT 25348397 N/A physical interaction ComPPI
BCAT2 C11ORF54 25348397 N/A physical interaction ComPPI
BCAT2 ETFA 25348397 N/A physical interaction ComPPI
BCAT2 UFM1 25348397 N/A physical interaction ComPPI
BCAT2 YBEY 25348397 N/A physical interaction ComPPI
BCAT2 NDUFS6 25348397 N/A physical interaction ComPPI
BCAT2 BCAT2 11264579 12269802 14525934 N/A experimental interaction detection HPRD
BCAT2 PEA15 24234451 30021884 physical association cross-linking study IntAct

Source Target Pmid Interactiontype Methods Database
URS00009BAE05 BCAT2 27087310 direct interaction,inhibition N/A NPInter

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