Gene Information gene info

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GENE：MICA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MICA
FullNmae MHC class I polypeptide-related sequence A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7090
EnsembleID ENSG00000204520
Uniprot Q29983

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MICA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MICA ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MICA GO:0001913,GO:0001916,GO:0002418,GO:0002476,GO:0002486,GO:0005102,GO:0005515,GO:0005615,GO:0005615,GO:0005737,GO:0005886,GO:0005886,GO:0006955,GO:0006974,GO:0009408,GO:0009897,GO:0009986,GO:0031640,GO:0032815,GO:0042267,GO:0042605,GO:0042742,GO:0045953,GO:0046629,GO:0046703,GO:0046703,GO:0051607

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MICA hsa:100507436 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
MICA hsa:100507436 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA2 MICA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HDAC1 MICA 17625602 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A MICA 21092233 trascriptional regulation,stimulation inferred by curator TFlink
HSF1 MICA 19139882 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 MICA 15494508 trascriptional regulation,stimulation inferred by curator TFlink
RELA MICA 15494508 trascriptional regulation,stimulation inferred by curator TFlink
SP1 MICA 19139882 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 MICA 19139882 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 MICA 21257710 23686482 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A MICA N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000508C13 MICA N/A 15685193 rna interference,inhibition array technology miRSponge
URS0000508C13 MICA 15685193 22100165 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS000027080C MICA 22100165 23820258 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,clip,miRNA interference luciferase reporter assay TarBase
URS0000001EB3 MICA 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 MICA 22100165 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 MICA 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 MICA 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 MICA 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 MICA 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 MICA 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000393C7 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000171FEC MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002D2333 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002E628F MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000009265 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000058863C MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000166778 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004AF715 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041E780 MICA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 MICA 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002FF522 MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005BB0FD MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000035AC91 MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000018D2BE MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003538C1 MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000048BA36 MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000083D87 MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C MICA 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
KLRK1 MICA 25361965 interaction type N/A PTMCode2
MICA KLRK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LGALS3 MICA 21712812 24234451 25348397 physical association anti tag coimmunoprecipitation,cross-linking study ComPPI,IntAct
SCAMP1 MICA 25348397 N/A physical interaction ComPPI
AVP MICA 25348397 N/A physical interaction ComPPI
UBB MICA 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBC MICA 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
RPS27A MICA 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 MICA 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
VAMP3 MICA 25348397 N/A physical interaction ComPPI
TAZ MICA 25348397 N/A physical interaction ComPPI
TRIM25 MICA 25348397 N/A physical interaction ComPPI
TNPO3 MICA 25348397 N/A physical interaction ComPPI
POT1 MICA 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
EPHA7 MICA 25348397 N/A physical interaction ComPPI
TNFSF9 MICA 25348397 N/A physical interaction ComPPI
TNFRSF10B MICA 25348397 N/A physical interaction ComPPI
KLRC4 MICA 10426993 11323699 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
KLRK1 MICA 10426993 11323699 12902493 14525934 21712812 24234451 25348397 N/A experimental interaction detection,surface plasmon resonance,x-ray crystallography,in vitro ComPPI,HPRD,IntAct
TNPO2 MICA 25348397 N/A physical interaction ComPPI
SCGB1D1 MICA 25348397 N/A physical interaction ComPPI
MICA GGH 25348397 N/A physical interaction ComPPI
MICA PGLYRP3 25348397 N/A physical interaction ComPPI
MICA VAC14 25348397 N/A physical interaction ComPPI
MICA FLVCR1 25348397 N/A physical interaction ComPPI
MICA RYK 25348397 N/A physical interaction ComPPI
MICA ADAP2 25348397 N/A physical interaction ComPPI
MICA NCR3LG1 25348397 N/A physical interaction ComPPI
MICA ERLEC1 25348397 N/A physical interaction ComPPI
MICA PGRMC2 25348397 N/A physical interaction ComPPI
MICA PHF7 25348397 N/A physical interaction ComPPI
MICA AAR2 25348397 N/A physical interaction ComPPI
MICA PTPRK 25348397 N/A physical interaction ComPPI
MICA DEFA5 25348397 N/A physical interaction ComPPI
MICA TCTN1 25348397 N/A physical interaction ComPPI
MICA LYPD4 25348397 N/A physical interaction ComPPI
MICA SPINK4 25348397 N/A physical interaction ComPPI
MICA DEFA1 25348397 N/A physical interaction ComPPI
MICA TAFA3 25348397 N/A physical interaction ComPPI
MICA INSL5 25348397 N/A physical interaction ComPPI
H2BC21 MICA 24234451 30021884 physical association cross-linking study IntAct

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