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GENE：TCF7L1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TCF7L1
FullNmae transcription factor 7 like 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11640
EnsembleID ENSG00000152284
Uniprot Q9HCS4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TCF7L1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TCF7L1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TCF7L1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TCF7L1 GO:0000978,GO:0000981,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005829,GO:0006325,GO:0006355,GO:0006357,GO:0030111,GO:0060070,GO:1990837,GO:1990907

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TCF7L1 hsa:83439 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa04520 Adherens junction - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa04916 Melanogenesis - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa04934 Cushing syndrome - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa05132 Salmonella infection - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa05200 Pathways in cancer - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa05210 Colorectal cancer - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa05213 Endometrial cancer - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa05215 Prostate cancer - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa05216 Thyroid cancer - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa05217 Basal cell carcinoma - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa05224 Breast cancer - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa05226 Gastric cancer - Homo sapiens (human)
TCF7L1 hsa:83439 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR TCF7L1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 TCF7L1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 TCF7L1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 TCF7L1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C TCF7L1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 TCF7L1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TCF7L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TCF7L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TCF7L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TCF7L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TCF7L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 TCF7L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 TCF7L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 TCF7L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TCF7L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FIGLA TCF7L1 18499083 trascriptional regulation,stimulation inferred by curator TFlink
ID3 TCF7L1 24492847 trascriptional regulation,stimulation inferred by curator TFlink
LDB1 TCF7L1 10767331 trascriptional regulation,stimulation inferred by curator TFlink
LEF1 TCF7L1 8479911 trascriptional regulation,stimulation inferred by curator TFlink
LMX1B TCF7L1 10767331 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003E1A9 TCF7L1 20005803 rna interference,inhibition experimental interaction detection miRSponge
URS000008DA94 TCF7L1 20005803 rna interference,inhibition experimental interaction detection miRSponge
URS000012A1DD TCF7L1 20005803 rna interference,inhibition experimental interaction detection miRSponge
URS0000171525 TCF7L1 20005803 rna interference,inhibition experimental interaction detection miRSponge
URS000055BBE5 TCF7L1 20005803 rna interference,inhibition experimental interaction detection miRSponge
URS000055BBE5 TCF7L1 20005803 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000008DA94 TCF7L1 20005803 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000171525 TCF7L1 20005803 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000003E1A9 TCF7L1 20005803 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000012A1DD TCF7L1 20005803 25416803 mrna cleavage,inhibition experimental interaction detection TarBase

Source Target Pmid Interactiontype Methods Database
CTNNB1 TCF7L1 11266540 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TCF7L1 NANOG 25348397 N/A physical interaction ComPPI
TCF7L1 POU5F1 25348397 N/A physical interaction ComPPI

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