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GENE：THRA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol THRA
FullNmae thyroid hormone receptor alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11796
EnsembleID ENSG00000126351
Uniprot P10827

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
THRA ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
THRA GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001502,GO:0001503,GO:0002154,GO:0002155,GO:0003700,GO:0004879,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006366,GO:0007611,GO:0008016,GO:0008050,GO:0008270,GO:0009409,GO:0009755,GO:0017025,GO:0017055,GO:0019904,GO:0030154,GO:0030218,GO:0030878,GO:0031490,GO:0033032,GO:0045892,GO:0045925,GO:0045944,GO:0048384,GO:0050994,GO:0060509,GO:0070324,GO:0070324,GO:0120162,GO:0140296,GO:2000143

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
THRA hsa:7067 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
THRA hsa:7067 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MED1 THRA 10891484 23180781 physical association pull down InnateDB
FOXJ1 THRA 21988832 23180781 physical association two hybrid InnateDB
THRA RXRB 10845098 1331778 23331499 stimulation N/A SignaLink
THRA RXRA 11018031 1331778 15604093 23331499 stimulation N/A SignaLink
RXRB THRA 10721822 23331499 stimulation N/A SignaLink
RXRA THRA 10845098 23331499 stimulation N/A SignaLink
NR0B2 THRA 11368516 23331499 stimulation N/A SignaLink
THRA RARG 15650024 23331499 stimulation N/A SignaLink
RARG THRA 15650024 23331499 stimulation N/A SignaLink
THRA RARA 15650024 23331499 stimulation N/A SignaLink
RARA THRA 15650024 23331499 stimulation N/A SignaLink
THRA RARB 15650024 23331499 stimulation N/A SignaLink
RARB THRA 15650024 23331499 stimulation N/A SignaLink
THRA RXRG 23331499 8127707 stimulation N/A SignaLink
RXRG THRA 23331499 8127707 stimulation N/A SignaLink
THRA NR2F2 23331499 7750494 stimulation N/A SignaLink
NR2F2 THRA 23331499 7750494 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
COPS2 THRA 20005715 interaction type N/A PSP
YWHAH THRA 20005715 interaction type N/A PSP
YWHAQ THRA 20005715 interaction type N/A PSP,SignaLink
YWHAH THRA 20005715 20005715 N/A N/A SignaLink
COPS2 THRA 10207062 10207062 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR THRA 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 THRA 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 THRA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 THRA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 THRA 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 THRA 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 THRA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA THRA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF THRA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 THRA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 THRA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A THRA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF THRA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 THRA 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000035CC3E THRA 16331254 25416803 mrna cleavage,inhibition array technology,northern blot TarBase
URS00000ED600 THRA 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D THRA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000007A060 THRA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000041CB9C THRA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000008A99 THRA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000018D2BE THRA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 THRA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB0E THRA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A THRA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B THRA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC THRA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB THRA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 THRA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000243FF1 THRA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000019D79B THRA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000364FEF THRA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001799A3 THRA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000004BACE THRA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D THRA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 THRA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000054A671 THRA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000821E0 THRA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D THRA 20371350 23313552 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA THRA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001CF056 THRA 23313552 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS000001C659 THRA 23313552 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00002367FA THRA 23313552 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000547F6A THRA 23313552 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00003D5391 THRA 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ARID5A THRA 25348397 N/A physical interaction ComPPI
UBE2I THRA 25348397 N/A physical interaction ComPPI
CCND1 THRA 12048199 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
AMOT THRA 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
RXRG THRA 14525934 25348397 27898060 8127707 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
NRIP1 THRA 10379889 15130509 21868449 25348397 27898060 9626662 N/A physical interaction ComPPI,OmniPath
EMD THRA 25348397 N/A physical interaction ComPPI
MED21 THRA 14525934 15249124 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
GTF2B THRA 14525934 25348397 27898060 7609079 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
MED8 THRA 14576168 24234451 25348397 association pull down ComPPI,IntAct
PIK3R1 THRA 16966610 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SRC THRA 14525934 15140878 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKDC THRA 25348397 N/A physical interaction ComPPI
CREBBP THRA 14525934 25348397 8616895 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TDG THRA 12874288 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NCOA3 THRA 25348397 N/A physical interaction ComPPI
NCOA1 THRA 14525934 15249124 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
EP300 THRA 25348397 N/A physical interaction ComPPI
HDAC3 THRA 25348397 N/A physical interaction ComPPI
AKAP13 THRA 14525934 24234451 25348397 9627117 N/A experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
THRA RXRB 1331778 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
THRA MEF2A 12371907 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
THRA NCOR2 25348397 N/A two hybrid,physical interaction,in vivo ComPPI
THRA YWHAH 11266503 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
THRA OASL 14525934 25348397 7776974 N/A two hybrid,two hybrid ComPPI,HPRD
THRA TRIM24 14525934 25348397 9115274 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
THRA PML 10610177 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
THRA MED1 14525934 24234451 25348397 9653119 physical association anti tag coimmunoprecipitation,experimental interaction detection,far western blotting,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
THRA COPS2 10207062 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
THRA HDAC2 25348397 N/A in vitro ComPPI
THRA NCOA6 10866662 11158331 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
THRA NSD1 14525934 25348397 9628876 N/A experimental interaction detection,in vitro ComPPI,HPRD
THRA SLC16A2 25348397 N/A in vitro,in vivo ComPPI
THRA CREB1 12805224 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
THRA ESR1 14525934 25348397 9717844 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
THRA CDK7 14525934 15249124 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
THRA CUL1 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
THRA NCOR1 11889044 12446772 14525934 15060155 15131262 15604093 17242407 21389087 25348397 27898060 7566114 9804773 9849963 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD,OmniPath
THRA RGN 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
THRA NR2F1 1331778 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
THRA FUS 14525934 25348397 9440806 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
THRA POU2F1 25348397 N/A physical interaction,in vivo ComPPI
THRA ITGB3BP 10490654 11713274 25348397 27898060 N/A physical interaction ComPPI,OmniPath
THRA DAP3 25348397 N/A physical interaction ComPPI
THRA NR0B2 25348397 N/A physical interaction ComPPI
THRA HR 25348397 N/A physical interaction ComPPI
THRA MED12 25348397 N/A physical interaction ComPPI
THRA MED16 25348397 N/A physical interaction ComPPI
THRA MED6 25348397 N/A physical interaction ComPPI
THRA MED24 25348397 N/A physical interaction ComPPI
THRA CDK8 25348397 N/A physical interaction ComPPI
THRA TRIP11 25348397 N/A physical interaction ComPPI
THRA RXRA 1331778 14525934 15604093 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
THRA ZBTB3 25348397 N/A physical interaction ComPPI
THRA SUV39H1 25348397 N/A physical interaction ComPPI
THRA PARP1 25348397 N/A physical interaction ComPPI
THRA NCOA2 25348397 N/A physical interaction ComPPI
THRA TAF11 25348397 N/A physical interaction ComPPI
THRA TAF7 25348397 N/A physical interaction ComPPI
THRA GRIP1 25348397 N/A physical interaction ComPPI
THRA SMC1A 25348397 N/A physical interaction ComPPI
THRA LIG3 25348397 N/A physical interaction ComPPI
THRA XRCC5 25348397 N/A physical interaction ComPPI
THRA XRCC6 25348397 N/A physical interaction ComPPI
THRA HSPA4 25348397 N/A physical interaction ComPPI
THRA GPS2 25348397 N/A physical interaction ComPPI
THRA TBL1X 25348397 N/A physical interaction ComPPI
THRA SELENOP 25348397 N/A physical interaction ComPPI
THRA MED25 25348397 N/A physical interaction ComPPI
THRA CLIC1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
THRA FOXJ1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
THRA PTGES3 25348397 N/A physical interaction ComPPI
THRA RANBP9 25348397 N/A physical interaction ComPPI
THRA AMOTL2 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
THRA L3MBTL3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
THRA ENO1 25348397 N/A physical interaction ComPPI
THRA MOV10 25348397 N/A physical interaction ComPPI
THRA NXF1 25348397 N/A physical interaction ComPPI
THRA CEP76 21516116 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
THRA TRIM63 25348397 26862156 27898060 N/A physical interaction ComPPI,OmniPath
THRA A2ML1 25348397 N/A physical interaction ComPPI
THRA HAL 25348397 N/A physical interaction ComPPI
THRA CST6 25348397 N/A physical interaction ComPPI
THRA MTNR1B 24234451 25348397 26514267 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
THRA HNRNPL 25348397 N/A physical interaction ComPPI
THRA MED29 14576168 24234451 25348397 association pull down ComPPI,IntAct
THRA MED17 14576168 24234451 25348397 association pull down ComPPI,IntAct
THRA UBE2V1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
THRA UBA1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
THRA UBE2N 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
THRA SYAP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
THRA PRKAR1B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BUB3 THRA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PKM THRA 25348397 N/A protein kinase assay ComPPI
YWHAQ THRA 25348397 N/A physical interaction ComPPI
C1D THRA 25348397 N/A physical interaction ComPPI
TBL1XR1 THRA 25348397 N/A physical interaction ComPPI
CD160 THRA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BTG1 THRA 14525934 15674337 N/A experimental interaction detection HPRD
RARA THRA 15650024 27898060 stimulant N/A OmniPath
THRA RARA 15650024 27898060 stimulant N/A OmniPath
THRA RXRA 10845098 11018031 11117530 1314167 1331778 15604093 19422879 27898060 stimulant N/A OmniPath
RXRA THRA 10845098 10976919 11018031 11117530 1314167 1331778 15604093 19422879 27898060 stimulant N/A OmniPath
THRA NR2F2 27898060 7750494 stimulant N/A OmniPath
NR2F2 THRA 27898060 7750494 stimulant N/A OmniPath
NR0B2 THRA 11368516 27898060 stimulant N/A OmniPath
THRA RARG 15650024 27898060 stimulant N/A OmniPath
RARG THRA 15650024 27898060 stimulant N/A OmniPath
THRA RXRB 10721822 10845098 1331778 27898060 stimulant N/A OmniPath
RXRB THRA 10721822 10845098 10976919 1331778 27898060 stimulant N/A OmniPath
RARB THRA 15650024 27898060 stimulant N/A OmniPath
THRA RARB 15650024 27898060 stimulant N/A OmniPath
TRIP11 THRA 27898060 9256431 stimulant N/A OmniPath

Visualization










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