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GENE：PSAP

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PSAP
FullNmae prosaposin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9498
EnsembleID ENSG00000197746
Uniprot P07602

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PSAP lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
PSAP lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PSAP ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSAP autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSAP autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PSAP GO:0002020,GO:0005515,GO:0005543,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005764,GO:0005764,GO:0005765,GO:0005770,GO:0005886,GO:0006665,GO:0007041,GO:0007041,GO:0007193,GO:0008047,GO:0010506,GO:0019216,GO:0035577,GO:0042803,GO:0043202,GO:0043231,GO:0060736,GO:0060742,GO:0062023,GO:0070062,GO:0097110,GO:1903771,GO:1905572,GO:1905573,GO:1905574,GO:1905575,GO:1905576,GO:1905577

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PSAP hsa:5660 path:hsa00600 Sphingolipid metabolism - Homo sapiens (human)
PSAP hsa:5660 path:hsa04142 Lysosome - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 PSAP 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PSAP 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PSAP 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC PSAP 12695333 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 PSAP 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
NR1I2 PSAP 19129222 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PSAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PSAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PSAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PSAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PSAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PSAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PSAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PSAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PSAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PSAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PSAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PSAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000006FDD4 PSAP 23451058 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000006FDD4 PSAP 22473208 23451058 25416803 mrna cleavage,inhibition clip,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 PSAP 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00002C0FCB PSAP 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00003D5391 PSAP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003FD55 PSAP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D PSAP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D PSAP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002B2B5C PSAP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000183BED PSAP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CC864 PSAP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001B341F PSAP 24966325 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000330617 PSAP 24966325 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000007F792 PSAP 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS000055128B PSAP 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5E03 PSAP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000009EA8F PSAP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004E02F2 PSAP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000BD6DC PSAP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000004BACE PSAP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000ECE9C PSAP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000001A7A PSAP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E728C PSAP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003AD2AA PSAP 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CTSD PSAP 25361965 interaction type N/A PTMCode2
PSAP CTSD 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ZBED1 PSAP 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
SAP18 PSAP 25348397 N/A physical interaction ComPPI
BAG3 PSAP 25348397 N/A physical interaction ComPPI
SNRPA1 PSAP 25348397 N/A physical interaction ComPPI
CASP14 PSAP 24234451 24872419 25348397 physical association pull down,proximity ligation assay ComPPI,IntAct
VCP PSAP 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
U2AF1L5 PSAP 25348397 N/A physical interaction ComPPI
APPBP2 PSAP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ERBB2 PSAP 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD2 PSAP 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MAFF PSAP 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
BCAT1 PSAP 25348397 N/A physical interaction ComPPI
CTSD PSAP 12083803 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
MVP PSAP 25348397 N/A physical interaction ComPPI
SMAD9 PSAP 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PLAUR PSAP 25348397 N/A physical interaction ComPPI
GBA PSAP 14525934 25348397 27898060 7613473 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PSAP BRCA1 11313879 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PSAP BACE1 14525934 15606899 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PSAP CD1B 14525934 14716313 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PSAP CELSR1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PSAP COPS6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PSAP PRAG1 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PSAP UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PSAP USP4 25348397 N/A physical interaction ComPPI
PSAP TCERG1 25348397 N/A physical interaction ComPPI
PSAP SMARCC2 25348397 N/A physical interaction ComPPI
PSAP SNAP23 25348397 N/A physical interaction ComPPI
PSAP NUP133 25348397 N/A physical interaction ComPPI
PSAP DNAJA1 25348397 N/A physical interaction ComPPI
PSAP SURF4 25348397 N/A physical interaction ComPPI
PSAP GDAP1 25348397 N/A physical interaction ComPPI
PSAP U2AF1 25348397 N/A physical interaction ComPPI
PSAP SUMO2 25348397 N/A physical interaction ComPPI
PSAP SNCA 25348397 N/A physical interaction ComPPI
PSAP SRSF5 25348397 N/A physical interaction ComPPI
PSAP SSR1 25348397 N/A physical interaction ComPPI
PSAP THRAP3 25348397 N/A physical interaction ComPPI
PSAP CFTR 17110338 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSAP FBXO6 25348397 N/A physical interaction ComPPI
PSAP C1QBP 25348397 N/A physical interaction ComPPI
PSAP GTF2F1 25348397 N/A physical interaction ComPPI
PSAP LAMB2 25348397 N/A physical interaction ComPPI
PSAP USP48 25348397 N/A physical interaction ComPPI
PSAP VPS29 25348397 N/A physical interaction ComPPI
PSAP NLGN3 25348397 N/A physical interaction ComPPI
PSAP SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PSAP SGCG 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
PSAP PRSS3 24234451 24872419 25348397 physical association proximity ligation assay ComPPI,IntAct
VPS35 PSAP 25348397 N/A physical interaction ComPPI
PSAP PSAP 12510003 12518053 14525934 N/A experimental interaction detection HPRD
PSAP GPR37 23690594 27898060 N/A N/A OmniPath
PSAP GPR37L1 23690594 27898060 N/A N/A OmniPath

Visualization










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