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GENE：DCLRE1C

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DCLRE1C
FullNmae DNA cross-link repair 1C
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17642
EnsembleID ENSG00000152457
Uniprot Q96SD1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DCLRE1C ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DCLRE1C GO:0000014,GO:0000723,GO:0002250,GO:0003684,GO:0004519,GO:0005515,GO:0005654,GO:0005654,GO:0005794,GO:0006303,GO:0006303,GO:0008409,GO:0010212,GO:0030183,GO:0033151,GO:0035312,GO:0036297,GO:0070419

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DCLRE1C hsa:64421 path:hsa03450 Non-homologous end-joining - Homo sapiens (human)
DCLRE1C hsa:64421 path:hsa05340 Primary immunodeficiency - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 DCLRE1C 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 DCLRE1C 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 DCLRE1C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DCLRE1C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DCLRE1C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DCLRE1C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DCLRE1C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DCLRE1C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DCLRE1C 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000005481D DCLRE1C 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000427B68 DCLRE1C 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB DCLRE1C 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 DCLRE1C 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D DCLRE1C 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKDC DCLRE1C 22135298 phosphorylation N/A PhosphoSite
ATR DCLRE1C 22135298 phosphorylation N/A PhosphoSite
ATM DCLRE1C 22135298 phosphorylation N/A PhosphoSite
DCLRE1C TP53BP1 25361965 interaction type N/A PTMCode2
TP53BP1 DCLRE1C 25361965 interaction type N/A PTMCode2
RAD50 DCLRE1C 25361965 interaction type N/A PTMCode2
DCLRE1C RAD50 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GOLGA2 DCLRE1C 25348397 N/A physical interaction ComPPI
PRKAA2 DCLRE1C 25348397 N/A physical interaction ComPPI
CDKN1B DCLRE1C 25348397 N/A physical interaction ComPPI
TP53BP1 DCLRE1C 14525934 15574327 16644291 16945145 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
PRKACB DCLRE1C 25348397 N/A physical interaction ComPPI
DDX20 DCLRE1C 25348397 N/A physical interaction ComPPI
FBXW7 DCLRE1C 25348397 N/A physical interaction ComPPI
ATR DCLRE1C 25348397 N/A physical interaction ComPPI
PRKDC DCLRE1C 11955432 14525934 15936993 22529269 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
LIG4 DCLRE1C 22529269 23219551 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence polarization spectroscopy,isothermal titration calorimetry,pull down,x-ray crystallography ComPPI,IntAct
PRKAA1 DCLRE1C 25348397 N/A physical interaction ComPPI
XRCC5 DCLRE1C 25348397 N/A physical interaction ComPPI
AKAP11 DCLRE1C 25348397 N/A physical interaction ComPPI
PRKAR1B DCLRE1C 25348397 N/A physical interaction ComPPI
PPP2R5E DCLRE1C 25348397 N/A physical interaction ComPPI
ATM DCLRE1C 14525934 15456891 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DDB2 DCLRE1C 25348397 N/A physical interaction ComPPI
DDB1 DCLRE1C 25348397 N/A physical interaction ComPPI
MRE11 DCLRE1C 14525934 15456891 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NBN DCLRE1C 14525934 15456891 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RAD50 DCLRE1C 14525934 15456891 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BRCA1 DCLRE1C 14525934 15456891 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKAB2 DCLRE1C 25348397 N/A physical interaction ComPPI
PRKAG1 DCLRE1C 25348397 N/A physical interaction ComPPI
PRKAB1 DCLRE1C 25348397 N/A physical interaction ComPPI
PRKAG2 DCLRE1C 25348397 N/A physical interaction ComPPI
MTHFR DCLRE1C 25348397 N/A physical interaction ComPPI
ZSWIM8 DCLRE1C 25348397 N/A physical interaction ComPPI
SPATA20 DCLRE1C 25348397 N/A physical interaction ComPPI
CDC27 DCLRE1C 25348397 N/A physical interaction ComPPI
DCLRE1C ANKRD52 25348397 N/A physical interaction ComPPI
DCLRE1C PPP6R2 25348397 N/A physical interaction ComPPI
DCLRE1C ANKRD28 25348397 N/A physical interaction ComPPI
DCLRE1C PPP6R1 25348397 N/A physical interaction ComPPI
DCLRE1C XRCC4 22529269 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
PASK DCLRE1C 25348397 N/A physical interaction ComPPI
TRIM26 DCLRE1C 25348397 N/A physical interaction ComPPI
ATR DCLRE1C 15468306 19423708 27898060 N/A N/A OmniPath
ATM DCLRE1C 15456891 15468306 15723659 16874298 21641068 23163657 27898060 stimulant N/A OmniPath
DCLRE1C XRCC4 16857680 27898060 stimulant N/A OmniPath
PRKDC DCLRE1C 11955432 15456891 15936993 16600297 16857680 16874298 27898060 stimulant N/A OmniPath

Visualization










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