Gene Information gene info

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GENE：TDG

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TDG
FullNmae thymine DNA glycosylase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11700
EnsembleID ENSG00000139372
Uniprot Q13569

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TDG mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TDG ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TDG GO:0000122,GO:0000287,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003712,GO:0004844,GO:0004844,GO:0005080,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005886,GO:0006284,GO:0006285,GO:0008263,GO:0008263,GO:0008263,GO:0016605,GO:0019104,GO:0019104,GO:0019104,GO:0019904,GO:0030983,GO:0031402,GO:0031404,GO:0032183,GO:0040029,GO:0043621,GO:0043739,GO:0045008,GO:0045995,GO:0080111,GO:0140297,GO:0141016

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TDG hsa:6996 path:hsa03410 Base excision repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR TDG 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR2 TDG 20034404 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 TDG 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TDG 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TDG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TDG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TDG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TDG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 TDG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DNMT3L TDG 20428781 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000272A3D TDG N/A 18390668 \N rna interference,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000272A3D TDG 18390668 18927107 22012620 23592263 23857059 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS00000F31F4 TDG 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 TDG 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00001F0C23 TDG 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000076995 TDG 22012620 23592263 23820384 23857059 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000077AED TDG 21572407 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005606AA TDG 21572407 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TDG SUMO2 25361965 interaction type N/A PTMCode2
SUMO2 TDG 25361965 interaction type N/A PTMCode2
TDG RXRA 25361965 interaction type N/A PTMCode2
RXRA TDG 25361965 interaction type N/A PTMCode2
SUMO1 TDG 25361965 interaction type N/A PTMCode2
TDG SUMO1 25361965 interaction type N/A PTMCode2
XPC TDG 25361965 interaction type N/A PTMCode2
TDG XPC 25361965 interaction type N/A PTMCode2
RAD23B TDG 25361965 interaction type N/A PTMCode2
TDG RAD23B 25361965 interaction type N/A PTMCode2
DNMT3B TDG 25361965 interaction type N/A PTMCode2
TDG DNMT3B 25361965 interaction type N/A PTMCode2
PML TDG 25361965 interaction type N/A PTMCode2
TDG PML 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I TDG 25348397 N/A physical interaction ComPPI
RARA TDG 25348397 N/A physical interaction ComPPI
PCNA TDG 25348397 N/A physical interaction ComPPI
SKIL TDG 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 TDG 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SNIP1 TDG 14525934 15231748 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
JUNB TDG 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
CRK TDG 25348397 N/A two hybrid,physical interaction ComPPI
JUN TDG 14525934 1631061 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
AR TDG 25348397 N/A physical interaction ComPPI
CREBBP TDG 11864601 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
TDG SUMO3 14525934 16620772 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TDG XPC 12505994 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
TDG NKX2-1 11438542 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
TDG VDR 12874288 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TDG SUMO1 10961991 11889051 14525934 16524884 16763556 17060459 21284855 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct,OmniPath
TDG EP300 11864601 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TDG RAD23B 12505994 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
TDG THRA 12874288 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TDG PML 14525934 15569683 17060459 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
TDG SUMO2 11889051 14525934 16620772 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TDG ESR1 12874288 14525934 16282588 24234451 25348397 association two hybrid,experimental interaction detection,physical interaction,chromatin immunoprecipitation assay,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
TDG DDX39B 14525934 14667819 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
TDG NR3C1 25348397 N/A physical interaction ComPPI
TDG RXRA 12874288 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TDG PGR 16282588 24234451 25348397 association,physical association physical interaction,chromatin immunoprecipitation assay ComPPI,IntAct
TDG TP53 25348397 N/A physical interaction ComPPI
TDG TP73 25348397 N/A physical interaction ComPPI
TDG DNMT3B 18452947 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TDG RNF4 25348397 N/A physical interaction ComPPI
TDG SERBP1 25348397 N/A physical interaction ComPPI
TDG IKZF1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TDG DTL 25348397 N/A physical interaction ComPPI
TDG TCF4 25348397 N/A physical interaction ComPPI
TDG NXF1 25348397 N/A physical interaction ComPPI
TDG MX1 25348397 N/A physical interaction ComPPI
TDG STAT3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TDG MYC 21150319 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TDG ZSCAN26 25348397 N/A physical interaction ComPPI
TDG EPM2A 25348397 N/A physical interaction ComPPI
TDG KDM6B 25348397 N/A physical interaction ComPPI
TDG FANCA 25348397 N/A physical interaction ComPPI
TDG TRIM25 25348397 N/A physical interaction ComPPI
TDG AICDA 21722948 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
TDG GADD45A 21722948 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
TDG SETX 24234451 24244371 25348397 physical association two hybrid ComPPI,IntAct
TDG TDG 14525934 14667819 18587051 24234451 N/A x-ray crystallography,two hybrid HPRD,IntAct
NCOA1 TDG 16282588 24234451 association,physical association anti bait coimmunoprecipitation,pull down,chromatin immunoprecipitation assay IntAct
TDG DNMT3A 17175537 27898060 N/A N/A OmniPath
TDG PGR 17129768 27898060 stimulant N/A OmniPath
TDG ESR1 12874288 17129768 27898060 stimulant N/A OmniPath
TDG CREBBP 11864601 17060459 17129768 24394593 24532795 24748645 27898060 stimulant N/A OmniPath
CREBBP TDG 11864601 17060459 17129768 24394593 24532795 24748645 27898060 stimulant N/A OmniPath
TDG AR 17129768 27898060 stimulant N/A OmniPath
EP300 TDG 11864601 27898060 stimulant N/A OmniPath
TDG NKX2-1 11438542 17129768 27898060 inhibition,stimulant N/A OmniPath
TDG NR3C1 17129768 27898060 stimulant N/A OmniPath

Visualization










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