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GENE：ACACB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACACB
FullNmae acetyl-CoA carboxylase beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:85
EnsembleID ENSG00000076555
Uniprot O00763

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACACB ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ACACB GO:0003989,GO:0003989,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005739,GO:0005741,GO:0005829,GO:0006084,GO:0006633,GO:0009374,GO:0009410,GO:0010629,GO:0010884,GO:0010906,GO:0014070,GO:0031667,GO:0031999,GO:0042802,GO:0046872,GO:0051289,GO:0060421,GO:0097009,GO:2001295

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ACACB hsa:32 path:hsa00061 Fatty acid biosynthesis - Homo sapiens (human)
ACACB hsa:32 path:hsa00620 Pyruvate metabolism - Homo sapiens (human)
ACACB hsa:32 path:hsa00640 Propanoate metabolism - Homo sapiens (human)
ACACB hsa:32 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ACACB hsa:32 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
ACACB hsa:32 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
ACACB hsa:32 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
ACACB hsa:32 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
ACACB hsa:32 path:hsa04931 Insulin resistance - Homo sapiens (human)
ACACB hsa:32 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR ACACB 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 ACACB 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 ACACB 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYF6 ACACB 11076940 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
MYOD1 ACACB 11076940 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
MYOG ACACB 11076940 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
CEBPA ACACB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ACACB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ACACB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ACACB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ACACB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR ACACB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SREBF1 ACACB 12764144 trascriptional regulation,stimulation inferred by curator TFlink
SP1 ACACB N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000521626 ACACB 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS000075D814 ACACB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 ACACB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC ACACB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000048BA36 ACACB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021202F ACACB 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKAA1 ACACB 22135298 phosphorylation N/A PhosphoSite
PRKAA2 ACACB 25361965 interaction type N/A PTMCode2
ACACB PRKAA2 25361965 interaction type N/A PTMCode2
ACACA ACACB 25361965 interaction type N/A PTMCode2
ACACB ACACA 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PRKAA2 ACACB 12413941 14525934 14532170 14613924 25348397 9148944 N/A experimental interaction detection,in vivo ComPPI,HPRD
KEAP1 ACACB 25348397 N/A physical interaction ComPPI
DPPA4 ACACB 25348397 N/A physical interaction ComPPI
H4C1 ACACB 25348397 N/A physical interaction ComPPI
MYC ACACB 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CD247 ACACB 24234451 24502978 25348397 association pull down ComPPI,IntAct
RPS6 ACACB 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HUWE1 ACACB 25348397 N/A physical interaction ComPPI
EGFR ACACB 25348397 N/A physical interaction ComPPI
PTEN ACACB 25348397 N/A physical interaction ComPPI
BCOR ACACB 25348397 N/A physical interaction ComPPI
DUSP22 ACACB 24234451 25348397 28330616 association pull down ComPPI,IntAct
ACACB ELAVL1 25348397 N/A physical interaction ComPPI
ACACB HLCS 20085763 24234451 25348397 27898060 enzymatic reaction nuclear magnetic resonance,physical interaction,enzymatic study ComPPI,IntAct,OmniPath
ACACB ANKRD28 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ACACB PCGF1 25348397 N/A physical interaction ComPPI
ACACB NANOGP8 25348397 N/A physical interaction ComPPI
ACACB NANOG 25348397 N/A physical interaction ComPPI
ACACB POU5F1 25348397 N/A physical interaction ComPPI
ACACB RGS1 25348397 N/A physical interaction ComPPI
ACACB PPP2R2B 25348397 N/A pull down ComPPI
ACACB ACACB 20457939 24234451 N/A molecular sieving,comigration in non denaturing gel electrophoresis IntAct
HMGA1 ACACB 24234451 30021884 physical association cross-linking study IntAct
PRKAA2 ACACB 12413941 14532170 14613924 20166139 27898060 9148944 inhibition N/A OmniPath
CSNK2A1 ACACB 12488245 27898060 N/A N/A OmniPath
PRKAA1 ACACB 12068056 12413941 12488245 16051629 27898060 inhibition N/A OmniPath

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