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GENE：DCTN3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DCTN3
FullNmae dynactin subunit 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2713
EnsembleID ENSG00000137100
Uniprot O75935

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DCTN3 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DCTN3 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DCTN3 GO:0000278,GO:0000776,GO:0005198,GO:0005515,GO:0005730,GO:0005813,GO:0005819,GO:0005829,GO:0005829,GO:0005869,GO:0005869,GO:0007017,GO:0030496,GO:0032154,GO:0048471,GO:0061640,GO:0061640

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DCTN3 hsa:11258 path:hsa04814 Motor proteins - Homo sapiens (human)
DCTN3 hsa:11258 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
DCTN3 hsa:11258 path:hsa05016 Huntington disease - Homo sapiens (human)
DCTN3 hsa:11258 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
DCTN3 hsa:11258 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 DCTN3 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 DCTN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DCTN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DCTN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DCTN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DCTN3 N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F2 DCTN3 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYC DCTN3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 DCTN3 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D DCTN3 23622248 23824327 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00005651EE DCTN3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C5969 DCTN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003003B4 DCTN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004C5774 DCTN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA DCTN3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003ACE11 DCTN3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 DCTN3 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DCTN3 DCTN1 25361965 interaction type N/A PTMCode2
DCTN1 DCTN3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NMI DCTN3 25348397 N/A physical interaction ComPPI
MAD2L2 DCTN3 25348397 N/A physical interaction ComPPI
MIS18A DCTN3 25348397 N/A physical interaction ComPPI
PBX2 DCTN3 14525934 14667819 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
ATXN1 DCTN3 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
UQCRH DCTN3 25348397 N/A physical interaction ComPPI
FHL2 DCTN3 25348397 N/A physical interaction ComPPI
GSK3B DCTN3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NUP85 DCTN3 25348397 N/A physical interaction ComPPI
PDGFD DCTN3 25348397 N/A physical interaction ComPPI
DYNLT3 DCTN3 25348397 N/A physical interaction ComPPI
DCTN1 DCTN3 14525934 24234451 25348397 26638075 27173435 9722614 association,physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification,proximity-dependent biotin identification,inference by socio-affinity scoring ComPPI,HPRD,IntAct
ACTR1A DCTN3 25348397 N/A physical interaction ComPPI
LMNB1 DCTN3 25348397 N/A physical interaction ComPPI
GPS2 DCTN3 25348397 N/A physical interaction ComPPI
FLNB DCTN3 25348397 N/A physical interaction ComPPI
LRIF1 DCTN3 25348397 N/A physical interaction ComPPI
RIC8A DCTN3 25348397 N/A physical interaction ComPPI
ASPM DCTN3 24234451 25348397 28436967 association pull down ComPPI,IntAct
AURKAIP1 DCTN3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
DCTN2 DCTN3 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
TNKS1BP1 DCTN3 25348397 N/A physical interaction ComPPI
DCTN3 ACTR1B 25348397 N/A physical interaction ComPPI
DCTN3 CCAR2 25348397 N/A physical interaction ComPPI
DCTN3 PHF19 25348397 N/A physical interaction ComPPI
DCTN3 THAP1 25348397 N/A physical interaction ComPPI
DCTN3 CSPP1 25348397 N/A physical interaction ComPPI
DCTN3 C4BPB 25348397 N/A physical interaction ComPPI
DCTN3 CAPZA2 25348397 N/A physical interaction ComPPI
DCTN3 CA10 25348397 N/A physical interaction ComPPI
DCTN3 MED4 25348397 N/A physical interaction ComPPI
DCTN3 SCLT1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DCTN3 L1TD1 25348397 N/A physical interaction ComPPI
DCTN3 DUSP13 25348397 N/A physical interaction ComPPI
DCTN3 DUSP13 25348397 N/A physical interaction ComPPI
DCTN3 DUSP28 25348397 N/A physical interaction ComPPI
DCTN3 DCTN6 25348397 N/A physical interaction ComPPI
DCTN3 KLHL2 25348397 N/A physical interaction ComPPI
DCTN3 ACTBL2 25348397 N/A physical interaction ComPPI
DCTN3 INAVA 25348397 N/A physical interaction ComPPI
DCTN3 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
ACTR10 DCTN3 25348397 N/A physical interaction ComPPI
RPS19BP1 DCTN3 25348397 N/A physical interaction ComPPI
LEO1 DCTN3 25348397 N/A physical interaction ComPPI
DEFB127 DCTN3 25348397 N/A physical interaction ComPPI

Visualization










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