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GENE：FANCI

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FANCI
FullNmae FA complementation group I
LocusType gene with protein product
Status Approved
HGNC_id HGNC:25568
EnsembleID ENSG00000140525
Uniprot Q9NVI1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FANCI parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FANCI mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FANCI GO:0000785,GO:0003677,GO:0005515,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0007049,GO:0016020,GO:0031398,GO:0036297,GO:0070182,GO:0070182,GO:1990391

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FANCI hsa:55215 path:hsa03460 Fanconi anemia pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BRCA1 FANCI 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20173781 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 26192618 9488723 interaction type N/A ACSN
BRCA2 FANCI 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20173781 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 26192618 9488723 interaction type N/A ACSN
FANCD2 FANCI 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14614141 14624239 14726013 15242590 15375219 15377654 15459660 15485915 15703371 16337601 16337602 16697054 16713580 16818604 17303408 17349954 17965729 18082604 18082605 18085520 18087292 18448394 18472307 18543256 18584027 18809224 18931676 18995830 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20064462 20173781 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 26192618 9488723 interaction type N/A ACSN
FANCI RAD51 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 26192618 9488723 interaction type N/A ACSN
PCNA FANCI 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 26192618 9488723 interaction type N/A ACSN
FANCI POLN 16337601 16337602 16697054 17965729 18087292 18448394 18472307 18584027 18809224 18931676 19622404 19686080 19772495 19793861 19793862 19841479 19847258 19995904 20064462 20723763 22101340 22751496 23444773 26192618 interaction type N/A ACSN
BLM FANCI 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FAAP100 FANCI 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FAAP20 FANCI 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FAAP24 FANCI 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCA FANCI 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCB FANCI 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCC FANCI 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCE FANCI 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCF FANCI 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCG FANCI 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCL FANCI 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCM FANCI 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
HES1 FANCI 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
UBE2T FANCI 12239151 16916645 18931676 19264559 19622404 19686080 20457011 22615860 26192618 interaction type N/A ACSN
ATR FANCI 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 26192618 9488723 9858600 interaction type N/A ACSN
CHEK1 FANCI 15459660 15798197 17102137 17116885 17296725 17384638 17582221 18677104 18931676 19686080 19793801 26192618 interaction type N/A ACSN
RPA1 FANCI 26192618 association N/A ACSN
RPA2 FANCI 26192618 association N/A ACSN
RPA3 FANCI 26192618 association N/A ACSN
USP1 FANCI 16531995 18082604 18082605 18931676 19075014 19217432 19264559 19622404 19686080 23589330 26192618 interaction type N/A ACSN
APP FANCI 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
AR FANCI 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 FANCI 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 FANCI 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 FANCI 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 FANCI 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 FANCI 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FANCI 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FANCI 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 FANCI 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 FANCI 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 FANCI 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000009262D FANCI 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS000017EA6A FANCI 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 FANCI 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
ATM FANCI 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
FANCI ATM 25361965 interaction type N/A PTMCode2
FANCD2 FANCI 25361965 interaction type N/A PTMCode2
FANCI FANCD2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNW1 FANCI 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L FANCI 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DPY30 FANCI 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IMPDH2 FANCI 25348397 N/A physical interaction ComPPI
EMD FANCI 25348397 N/A physical interaction ComPPI
VCP FANCI 25348397 N/A physical interaction ComPPI
MCM5 FANCI 25348397 N/A physical interaction ComPPI
MCM2 FANCI 25348397 N/A physical interaction ComPPI
ATR FANCI 25348397 N/A physical interaction ComPPI
PIAS1 FANCI 25348397 N/A physical interaction ComPPI
CUL3 FANCI 25348397 N/A physical interaction ComPPI
PPM1A FANCI 25348397 N/A physical interaction ComPPI
UBB FANCI 25348397 N/A anti bait coimmunoprecipitation,covalent binding,comigration in sds page ComPPI
UBC FANCI 25348397 N/A anti bait coimmunoprecipitation,covalent binding,comigration in sds page ComPPI
RPS27A FANCI 25348397 N/A anti bait coimmunoprecipitation,covalent binding,comigration in sds page ComPPI
UBA52 FANCI 25348397 N/A anti bait coimmunoprecipitation,covalent binding,comigration in sds page ComPPI
NTRK1 FANCI 25348397 N/A physical interaction ComPPI
ILK FANCI 17353931 23455922 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
MYC FANCI 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TNFRSF1A FANCI 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
UHRF2 FANCI 25348397 N/A physical interaction ComPPI
FSCN1 FANCI 20603015 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down ComPPI,IntAct
MAPK6 FANCI 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
RAD18 FANCI 25348397 N/A physical interaction ComPPI
RAD51 FANCI 25348397 N/A physical interaction ComPPI
FANCD2 FANCI 14525934 17460694 20603015 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction,in vitro ComPPI,HPRD,IntAct
BRCA2 FANCI 25348397 N/A physical interaction ComPPI
ATM FANCI 25348397 N/A physical interaction ComPPI
BRF2 FANCI 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ABCE1 FANCI 25348397 N/A physical interaction ComPPI
RPS6 FANCI 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
STXBP2 FANCI 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MMS19 FANCI 25348397 N/A physical interaction ComPPI
PIAS4 FANCI 25348397 N/A physical interaction ComPPI
TNFRSF1B FANCI 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAGED1 FANCI 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TIMM23 FANCI 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RUNX3 FANCI 25348397 N/A physical interaction ComPPI
TRIM25 FANCI 25348397 N/A physical interaction ComPPI
CIR1 FANCI 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MCM3 FANCI 25348397 N/A physical interaction ComPPI
BRCA1 FANCI 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
AKT1 FANCI 25348397 N/A physical interaction ComPPI
SENP6 FANCI 25348397 N/A physical interaction ComPPI
HACD3 FANCI 25348397 N/A physical interaction ComPPI
TGOLN2 FANCI 24234451 25348397 29568061 association pull down ComPPI,IntAct
REV1 FANCI 25348397 N/A physical interaction ComPPI
AURKAIP1 FANCI 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PRKAB2 FANCI 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 FANCI 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BET1 FANCI 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CAMKK2 FANCI 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBL5 FANCI 25348397 N/A physical interaction ComPPI
RRP1B FANCI 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
FANCL FANCI 25348397 N/A physical interaction ComPPI
TSC22D1 FANCI 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DGCR8 FANCI 25348397 N/A physical interaction ComPPI
L3MBTL1 FANCI 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
PIDD1 FANCI 25348397 N/A physical interaction ComPPI
PAPSS1 FANCI 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POU5F1 FANCI 25348397 N/A physical interaction ComPPI
SIRT7 FANCI 25348397 N/A physical interaction ComPPI
FANCI PTP4A3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FANCI RAB5IF 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FANCI GSTK1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FANCI USP36 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FANCI CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FANCI FAN1 25348397 N/A physical interaction ComPPI
FANCI WDR48 25348397 N/A physical interaction ComPPI
FANCI APP 25348397 N/A physical interaction ComPPI
FANCI HBS1L 25348397 N/A physical interaction ComPPI
FANCI MOV10 25348397 N/A physical interaction ComPPI
FANCI NXF1 25348397 N/A physical interaction ComPPI
FANCI CEP120 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
FANCI DDOST 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FANCI IMPACT 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FANCI PRR3 25348397 N/A physical interaction ComPPI
FANCI PLEKHA8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FANCI FAAP20 25348397 N/A physical interaction ComPPI
FANCI HELQ 24005329 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FANCI FANCM 25348397 N/A physical interaction ComPPI
FANCI MTNR1B 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
FANCI PHLPP1 25348397 N/A physical interaction ComPPI
FANCI PHLPP2 25348397 N/A physical interaction ComPPI
PELO FANCI 25348397 N/A physical interaction ComPPI
UBE2T FANCI 17768402 27898060 stimulant N/A OmniPath
ATR FANCI 18931676 27898060 stimulant N/A OmniPath
USP1 FANCI 17488615 27898060 inhibition,stimulant N/A OmniPath
FANCI FANCL 17488615 19622405 21775430 24623813 27898060 stimulant N/A OmniPath
FANCL FANCI 17488615 19622405 21775430 24623813 27898060 stimulant N/A OmniPath
DUSP1 FANCI 17488615 27898060 inhibition N/A OmniPath

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