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GENE：ID2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ID2
FullNmae inhibitor of DNA binding 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5361
EnsembleID ENSG00000115738
Uniprot Q02363

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ID2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ID2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ID2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ID2 GO:0000122,GO:0000122,GO:0000791,GO:0003166,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007507,GO:0007623,GO:0010628,GO:0010629,GO:0019216,GO:0021772,GO:0030154,GO:0032922,GO:0032922,GO:0032991,GO:0033598,GO:0042752,GO:0043153,GO:0043353,GO:0043433,GO:0044325,GO:0045475,GO:0045578,GO:0045600,GO:0045651,GO:0045664,GO:0045777,GO:0045892,GO:0045893,GO:0046983,GO:0048557,GO:0048661,GO:0048663,GO:0048711,GO:0051148,GO:0060749,GO:0061030,GO:0061031,GO:0061629,GO:0071931,GO:0090398,GO:0140110,GO:0140416,GO:0140416,GO:2000045,GO:2000177

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ID2 hsa:3398 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
ID2 hsa:3398 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
ID2 hsa:3398 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
ID2 hsa:3398 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR ID2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 ID2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 ID2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 ID2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ID2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 ID2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC ID2 12545167 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ID2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ID2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ID2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ID2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ID2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ID2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ID2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ID2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ID2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A ID2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ID2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ID2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ID2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ID2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ID2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ID2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FLI1 ID2 12447693 trascriptional regulation,stimulation inferred by curator TFlink
HOXA10 ID2 20565746 trascriptional regulation,stimulation inferred by curator TFlink
HOXA9 ID2 20565746 trascriptional regulation,stimulation inferred by curator TFlink
MYCN ID2 12670915 trascriptional regulation,stimulation inferred by curator TFlink
POU2AF1 ID2 24801987 trascriptional regulation,stimulation inferred by curator TFlink
POU2F2 ID2 24801987 trascriptional regulation,stimulation inferred by curator TFlink
POU5F1 ID2 17068183 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ID2 16557594 trascriptional regulation,stimulation inferred by curator TFlink
TP63 ID2 21478550 trascriptional regulation,stimulation inferred by curator TFlink
ZBTB16 ID2 19723763 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 ID2 N/A trascriptional regulation,stimulation inferred by curator TFlink
CREB1 ID2 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD1 ID2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 ID2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 ID2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000451A1 ID2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002E177F ID2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D ID2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C ID2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000153377 ID2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00000F7766 ID2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000029EBD ID2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000048B5E9 ID2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000237AF9 ID2 23446348 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DYRK1B ID2 22135298 phosphorylation N/A PhosphoSite
ID2 TCF3 25361965 interaction type N/A PTMCode2
TCF3 ID2 25361965 interaction type N/A PTMCode2
ID2 CDK2 25361965 interaction type N/A PTMCode2
CDK2 ID2 25361965 interaction type N/A PTMCode2
ID2 TCF4 25361965 interaction type N/A PTMCode2
TCF4 ID2 25361965 interaction type N/A PTMCode2
ID2 PAX5 25361965 interaction type N/A PTMCode2
PAX5 ID2 25361965 interaction type N/A PTMCode2
HES1 ID2 25361965 interaction type N/A PTMCode2
ID2 HES1 25361965 interaction type N/A PTMCode2
SPI1 ID2 25361965 interaction type N/A PTMCode2
ID2 SPI1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
FNDC11 ID2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FRS3 ID2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCHP ID2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HSPA8 ID2 25348397 N/A physical interaction ComPPI
MYOG ID2 14525934 25348397 9242638 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
TUBB ID2 25348397 N/A physical interaction ComPPI
PICK1 ID2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK1 ID2 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8 ID2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MYOD1 ID2 14525934 25348397 9242638 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
MAPK3 ID2 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UNC119 ID2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NEDD9 ID2 10502414 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
RB1 ID2 11034201 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PAX2 ID2 25348397 N/A in vitro ComPPI
CCNDBP1 ID2 22453338 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
TUBA1B ID2 25348397 N/A physical interaction ComPPI
WBP11 ID2 25348397 N/A physical interaction ComPPI
UBB ID2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBC ID2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
RPS27A ID2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 ID2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
TNS2 ID2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PKD2 ID2 16311606 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,confocal microscopy ComPPI,IntAct,OmniPath
HSPA5 ID2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RBL2 ID2 11034201 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HSPA1A ID2 25348397 N/A physical interaction ComPPI
HSPA1B ID2 25348397 N/A physical interaction ComPPI
SIN3A ID2 25348397 N/A physical interaction ComPPI
PPP1CA ID2 14525934 17274640 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRMT5 ID2 25348397 N/A physical interaction ComPPI
SREBF1 ID2 25348397 N/A physical interaction ComPPI
ELK1 ID2 10022839 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
DYRK1B ID2 25348397 N/A physical interaction ComPPI
PDLIM5 ID2 16549780 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct
SQSTM1 ID2 25348397 N/A physical interaction ComPPI
STK38 ID2 25348397 N/A physical interaction ComPPI
RIN3 ID2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CLASP2 ID2 25348397 N/A physical interaction ComPPI
SUV39H1 ID2 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
E2F4 ID2 25348397 N/A physical interaction ComPPI
NR0B2 ID2 25348397 N/A physical interaction ComPPI
CDK2 ID2 14525934 25348397 9029153 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
YY1 ID2 25348397 N/A physical interaction ComPPI
GATA4 ID2 25348397 N/A physical interaction ComPPI
VHL ID2 25348397 N/A physical interaction ComPPI
TUBB4B ID2 25348397 N/A physical interaction ComPPI
HSPA9 ID2 25348397 N/A physical interaction ComPPI
RBM48 ID2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ELOC ID2 25348397 N/A physical interaction ComPPI
ELK4 ID2 10022839 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELK3 ID2 10022839 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ID4 ID2 25348397 N/A physical interaction ComPPI
LRIF1 ID2 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
TCF12 ID2 14525934 16549780 19321746 24234451 25348397 9242638 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ID2 MSC 11560778 14525934 25348397 27898060 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD,OmniPath
ID2 MYF6 14525934 25348397 9242638 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
ID2 RBL1 11034201 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ID2 HES1 11756408 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
ID2 IFI16 11940648 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ID2 ADD1 10585876 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ID2 TCF3 11591653 14525934 19321746 24234451 25348397 9242638 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
ID2 MYF5 14525934 25348397 9242638 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
ID2 TCF4 11591653 14525934 16549780 24234451 25348397 25609649 9242638 association,physical association two hybrid,experimental interaction detection,physical interaction,tandem affinity purification,two hybrid ComPPI,HPRD,IntAct
ID2 BCAR1 25348397 N/A physical interaction ComPPI
ID2 NKX2-5 25348397 N/A physical interaction ComPPI
ID2 USP1 25348397 N/A physical interaction ComPPI
ID2 GFUS 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ID2 KDM1A 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ID2 PRMT6 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ID2 SUV39H2 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ID2 ASB4 24586788 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ID2 DYRK1A 25348397 N/A physical interaction ComPPI
ID2 RNF113A 25348397 N/A physical interaction ComPPI
ID2 ELP4 25348397 N/A physical interaction ComPPI
ID2 HSPA1L 25348397 N/A physical interaction ComPPI
ID2 RHOU 25348397 N/A physical interaction ComPPI
ID2 PHF3 25348397 N/A physical interaction ComPPI
ID2 ZGPAT 25348397 N/A physical interaction ComPPI
ID2 MACF1 25348397 N/A physical interaction ComPPI
ID2 DIDO1 25348397 N/A physical interaction ComPPI
ID2 SLTM 25348397 N/A physical interaction ComPPI
ID2 RCBTB2 25348397 N/A physical interaction ComPPI
ID2 RABL6 25348397 N/A physical interaction ComPPI
ID2 C1ORF131 25348397 N/A physical interaction ComPPI
ID2 AFDN 25348397 N/A physical interaction ComPPI
ID2 RBM27 25348397 N/A physical interaction ComPPI
ID2 HDGFL2 25348397 N/A physical interaction ComPPI
ID2 UBE2E1 25348397 N/A physical interaction ComPPI
ID2 CFDP1 25348397 N/A physical interaction ComPPI
ID2 KIF20B 25348397 N/A physical interaction ComPPI
ID2 KLHL20 25348397 N/A physical interaction ComPPI
ID2 RIF1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ID2 ENKD1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ID2 FANCL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ID2 C22ORF39 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ID2 MSGN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ASCL4 ID2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EEF1A2 ID2 25348397 N/A physical interaction ComPPI
ID2 ID2 10891368 14525934 16549780 21988832 24234451 physical association two hybrid,experimental interaction detection,two hybrid HPRD,IntAct
PAX5 ID2 11134340 14525934 N/A experimental interaction detection HPRD
PAX8 ID2 11134340 14525934 N/A experimental interaction detection HPRD
ID2 FZR1 16810178 27898060 N/A N/A OmniPath
CDK2 ID2 27898060 9029153 9372912 inhibition N/A OmniPath
ZBTB16 ID2 19723763 27898060 stimulant N/A OmniPath
ID2 ATOH1 16407553 27898060 inhibition N/A OmniPath
TP53 ID2 16557594 27898060 stimulant N/A OmniPath

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