GENE：FBXO5
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | FBXO5 |
| FullNmae | F-box protein 5 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:13584 |
| EnsembleID | ENSG00000112029 |
| Uniprot | Q9UKT4 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| FBXO5 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| FBXO5 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| FBXO5 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| FBXO5 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| FBXO5 | GO:0001556,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0006275,GO:0006974,GO:0007057,GO:0007088,GO:0007346,GO:0008284,GO:0010971,GO:0010997,GO:0016050,GO:0016567,GO:0019901,GO:0032876,GO:0045669,GO:0045835,GO:0045841,GO:0046785,GO:0046872,GO:0051301,GO:0051444,GO:0070169,GO:0072687,GO:0140678,GO:0140678,GO:1904667,GO:1904667,GO:1905322,GO:1990948,GO:2000773 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| FBXO5 | hsa:26271 | path:hsa04110 | Cell cycle - Homo sapiens (human) |
| FBXO5 | hsa:26271 | path:hsa04114 | Oocyte meiosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | FBXO5 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | FBXO5 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ETS1 | FBXO5 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | FBXO5 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | FBXO5 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | FBXO5 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | FBXO5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | FBXO5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | FBXO5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | FBXO5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | FBXO5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | FBXO5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | FBXO5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000AA464 | FBXO5 | 20304954 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000016C318 | FBXO5 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00000F31F4 | FBXO5 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000B59A2 | FBXO5 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000003ABC4 | FBXO5 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SRC | FBXO5 | 22135298 | phosphorylation | N/A | PhosphoSite |
| PLK1 | FBXO5 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| FBXO5 | SKP1 | 25361965 | interaction type | N/A | PTMCode2 |
| SKP1 | FBXO5 | 25361965 | interaction type | N/A | PTMCode2 |
| FBXO5 | PLK1 | 25361965 | interaction type | N/A | PTMCode2 |
| FBXO5 | CDC20 | 25361965 | interaction type | N/A | PTMCode2 |
| CDC20 | FBXO5 | 25361965 | interaction type | N/A | PTMCode2 |
| FBXO5 | CDC16 | 25361965 | interaction type | N/A | PTMCode2 |
| CDC16 | FBXO5 | 25361965 | interaction type | N/A | PTMCode2 |
| FBXO5 | BTRC | 25361965 | interaction type | N/A | PTMCode2 |
| BTRC | FBXO5 | 25361965 | interaction type | N/A | PTMCode2 |
| FBXO5 | EVI5 | 25361965 | interaction type | N/A | PTMCode2 |
| EVI5 | FBXO5 | 25361965 | interaction type | N/A | PTMCode2 |
| FBXO5 | CDC26 | 25361965 | interaction type | N/A | PTMCode2 |
| CDC26 | FBXO5 | 25361965 | interaction type | N/A | PTMCode2 |
| FBXO5 | FZR1 | 25361965 | interaction type | N/A | PTMCode2 |
| FZR1 | FBXO5 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GMNN | FBXO5 | 25348397 | N/A | pull down,physical interaction | ComPPI |
| SKP1 | FBXO5 | 10531035 14525934 17380122 24234451 25348397 27705803 | association,physical association | two hybrid,experimental interaction detection,physical interaction,in vitro,tandem affinity purification,two hybrid | ComPPI,HPRD,IntAct |
| SRC | FBXO5 | 25348397 | N/A | physical interaction | ComPPI |
| CDC16 | FBXO5 | 20360068 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| FZR1 | FBXO5 | 11988738 14525934 25348397 | N/A | experimental interaction detection,pull down,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| ENO1 | FBXO5 | 25348397 | N/A | physical interaction | ComPPI |
| BTRC | FBXO5 | 25348397 | N/A | physical interaction | ComPPI |
| PLK1 | FBXO5 | 16439210 24234451 25348397 | phosphorylation reaction | physical interaction,protein kinase assay | ComPPI,IntAct |
| TPM3 | FBXO5 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| ANAPC10 | FBXO5 | 25348397 | N/A | pull down,physical interaction | ComPPI |
| CDC20 | FBXO5 | 11389834 11976684 11988738 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| FBXO5 | EVI5 | 14525934 16439210 24234451 25348397 | phosphorylation reaction,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,protein kinase assay,in vivo | ComPPI,HPRD,IntAct |
| FBXO5 | CDC27 | 17719540 18662541 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| FBXO5 | CDK1 | 25348397 | N/A | physical interaction | ComPPI |
| FBXO5 | FBXW11 | 25348397 | N/A | physical interaction | ComPPI |
| FBXO5 | ANAPC1 | 25348397 | N/A | physical interaction | ComPPI |
| FBXO5 | ANAPC5 | 25348397 | N/A | physical interaction | ComPPI |
| FBXO5 | ANAPC7 | 25348397 | N/A | physical interaction | ComPPI |
| FBXO5 | ANAPC2 | 25348397 | N/A | pull down,physical interaction,physical interaction | ComPPI |
| FBXO5 | ANAPC4 | 25348397 | N/A | pull down,physical interaction,physical interaction | ComPPI |
| FBXO5 | CDC23 | 25348397 | N/A | pull down,physical interaction,physical interaction | ComPPI |
| FBXO5 | ANAPC11 | 25348397 | N/A | physical interaction | ComPPI |
| FBXO5 | BRCA1 | 25348397 | N/A | physical interaction | ComPPI |
| FBXO5 | BARD1 | 25348397 | N/A | physical interaction | ComPPI |
| FBXO5 | UBE2S | 25348397 | N/A | pull down,physical interaction,physical interaction | ComPPI |
| FBXO5 | SHMT2 | 25348397 | N/A | physical interaction | ComPPI |
| FBXO5 | MOV10 | 25348397 | N/A | physical interaction | ComPPI |
| FBXO5 | NXF1 | 25348397 | N/A | physical interaction | ComPPI |
| FBXO5 | ANAPC15 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| FBXO5 | CHMP4B | 25348397 | N/A | physical interaction | ComPPI |
| CDC26 | FBXO5 | 20360068 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| ANAPC13 | FBXO5 | 25348397 | N/A | physical interaction | ComPPI |
| SRC | FBXO5 | 20717963 27898060 | stimulant | N/A | OmniPath |
| FBXO5 | CDH1 | 11751633 27898060 | inhibition | N/A | OmniPath |
| PLK1 | FBXO5 | 15148369 15469984 16439210 17875940 27898060 | inhibition,stimulant | N/A | OmniPath |
| PIN1 | FBXO5 | 17875940 27898060 | stimulant | N/A | OmniPath |
| FBXO5 | FZR1 | 11751633 11988738 16439210 16921029 27898060 | inhibition | N/A | OmniPath |
| FBXO5 | ANAPC7 | 11751633 16921029 27898060 | inhibition | N/A | OmniPath |
| CDK1 | FBXO5 | 17875940 27898060 | inhibition,stimulant | N/A | OmniPath |
| FBXO5 | CDC20 | 11389834 11751633 11976684 11988738 15678131 25750436 27898060 | inhibition | N/A | OmniPath |
| FBXO5 | ANAPC11 | 16439210 16921029 27898060 | inhibition | N/A | OmniPath |
| BTRC | FBXO5 | 12791266 15469984 17875940 25900982 26091241 27898060 | inhibition | N/A | OmniPath |