GENE：CAPN3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CAPN3 |
| FullNmae | calpain 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1480 |
| EnsembleID | ENSG00000092529 |
| Uniprot | P20807 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CAPN3 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CAPN3 | GO:0003824,GO:0004198,GO:0004198,GO:0004198,GO:0005509,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006508,GO:0006915,GO:0007517,GO:0008233,GO:0008234,GO:0008307,GO:0014718,GO:0014850,GO:0030016,GO:0030018,GO:0030163,GO:0030163,GO:0030239,GO:0030239,GO:0030315,GO:0031402,GO:0031432,GO:0031648,GO:0032991,GO:0033234,GO:0043066,GO:0043066,GO:0043122,GO:0045214,GO:0045661,GO:0045862,GO:0045892,GO:0045893,GO:0046716,GO:0050790,GO:0051092,GO:0051281,GO:0051592,GO:0055103,GO:0060090,GO:0061061,GO:0065003,GO:0070315,GO:0071277,GO:0071472,GO:0072657,GO:0097264,GO:1990092 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | CAPN3 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | CAPN3 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | CAPN3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CAPN3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CAPN3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | CAPN3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | CAPN3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NECAB2 | CAPN3 | 14525934 16189514 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
| CRYAB | CAPN3 | 23414517 24234451 25348397 | physical association | two hybrid fragment pooling approach | ComPPI,IntAct |
| PSMC3 | CAPN3 | 23414517 24234451 25348397 | physical association | two hybrid fragment pooling approach | ComPPI,IntAct |
| AMOT | CAPN3 | 23414517 24234451 25348397 | physical association | two hybrid fragment pooling approach | ComPPI,IntAct |
| FLNC | CAPN3 | 14506720 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| TTN | CAPN3 | 20860623 23414517 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid fragment pooling approach,in vitro,in vivo | ComPPI,IntAct |
| CAPN3 | OSGIN1 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| CAPN3 | NTAQ1 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| CAPN3 | CMYA5 | 23414517 24234451 25348397 | physical association | two hybrid fragment pooling approach | ComPPI,IntAct |
| CAPN3 | MMP2 | 23414517 24234451 25348397 | physical association | two hybrid fragment pooling approach | ComPPI,IntAct |
| CAPN3 | PSMD1 | 23414517 24234451 25348397 | physical association | two hybrid fragment pooling approach | ComPPI,IntAct |
| YWHAQ | CAPN3 | 14525934 15324660 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| MYC | CAPN3 | 16915296 27898060 | stimulant | N/A | OmniPath |
| CAPN3 | GSK3A | 25969760 27898060 | stimulant | N/A | OmniPath |
| CAPN3 | NFKBIA | 27898060 9873017 | N/A | N/A | OmniPath |
| CAPN3 | MAPT | 25969760 27898060 | inhibition | N/A | OmniPath |
| CAPN3 | GSK3B | 25969760 27898060 | stimulant | N/A | OmniPath |
| CAPN3 | CDK5R1 | 25969760 27898060 | stimulant | N/A | OmniPath |
| CAST | CAPN3 | 25969760 27898060 | inhibition | N/A | OmniPath |