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GENE：COL2A1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol COL2A1
FullNmae collagen type II alpha 1 chain
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2200
EnsembleID ENSG00000139219
Uniprot P02458

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
COL2A1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
COL2A1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
COL2A1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
COL2A1 GO:0001501,GO:0001501,GO:0001502,GO:0001894,GO:0001958,GO:0002062,GO:0003007,GO:0005576,GO:0005576,GO:0005585,GO:0005585,GO:0005592,GO:0005604,GO:0005615,GO:0005615,GO:0005788,GO:0006029,GO:0007417,GO:0007601,GO:0007605,GO:0010468,GO:0030020,GO:0030020,GO:0030020,GO:0030020,GO:0030199,GO:0030199,GO:0030903,GO:0042289,GO:0042472,GO:0042803,GO:0043394,GO:0046872,GO:0048407,GO:0051216,GO:0060021,GO:0060174,GO:0060272,GO:0060351,GO:0062023,GO:0062023,GO:0062023,GO:0071599,GO:0071773,GO:0097065,GO:0097192,GO:2001240

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
COL2A1 hsa:1280 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
COL2A1 hsa:1280 path:hsa04510 Focal adhesion - Homo sapiens (human)
COL2A1 hsa:1280 path:hsa04512 ECM-receptor interaction - Homo sapiens (human)
COL2A1 hsa:1280 path:hsa04974 Protein digestion and absorption - Homo sapiens (human)
COL2A1 hsa:1280 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MMP1 COL2A1 23691193 24376839 26192618 interaction type N/A ACSN
MMP9 COL2A1 21900405 26192618 interaction type N/A ACSN
MMP13 COL2A1 21900405 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 COL2A1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 COL2A1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HES1 COL2A1 18759300 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HEY1 COL2A1 18759300 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 COL2A1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 COL2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 COL2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 COL2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 COL2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A COL2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 COL2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 COL2A1 19022820 trascriptional regulation,stimulation inferred by curator TFlink
RELA COL2A1 19022820 trascriptional regulation,stimulation inferred by curator TFlink
SOX9 COL2A1 12713737 15623506 18636947 18759300 20039424 20529846 trascriptional regulation,stimulation inferred by curator TFlink
SP1 COL2A1 12888570 18065760 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 COL2A1 12888570 18065760 trascriptional regulation,stimulation inferred by curator TFlink
SP3 COL2A1 12888570 18065760 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000039E1E1 COL2A1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
C1QTNF2 COL2A1 25348397 N/A physical interaction ComPPI
TGFB1 COL2A1 10085302 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BGN COL2A1 14525934 2059554 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
DDR1 COL2A1 14525934 25348397 9659900 N/A experimental interaction detection,in vivo ComPPI,HPRD
PKD1 COL2A1 11406351 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
SPARC COL2A1 14525934 25348397 2745554 N/A experimental interaction detection,in vitro ComPPI,HPRD
THBS1 COL2A1 14525934 25348397 3571333 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PCOLCE COL2A1 12393877 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PDGFB COL2A1 25348397 N/A physical interaction ComPPI
PDGFA COL2A1 25348397 N/A physical interaction ComPPI
ITGA2B COL2A1 10772239 14525934 25348397 7520045 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MMP13 COL2A1 14525934 25348397 8609233 N/A experimental interaction detection,in vitro ComPPI,HPRD
RELA COL2A1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
C1QA COL2A1 14525934 25348397 27898060 8778019 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PDIA2 COL2A1 25348397 N/A physical interaction ComPPI
COL2A1 BMP2 10085302 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
COL2A1 MATN1 10196235 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
COL2A1 COL6A1 14525934 1544908 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
COL2A1 COL9A2 11724554 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
COL2A1 COL9A3 11724554 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
COL2A1 ANXA5 1397263 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
COL2A1 FGF7 11973338 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
COL2A1 MAG 14525934 2446864 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
COL2A1 COMP 14525934 25348397 27898060 9685393 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
COL2A1 PRELP 11847210 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
COL2A1 CHAD 11445564 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
COL2A1 TNFRSF10A 14525934 25348397 27898060 9811967 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
COL2A1 HTRA1 14525934 15101818 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
COL2A1 COL9A1 25348397 N/A physical interaction ComPPI
COL2A1 HYAL1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
COL2A1 C1QTNF9 25348397 N/A physical interaction ComPPI
COL2A1 PLOD1 25348397 N/A physical interaction ComPPI
COL2A1 MMP9 25348397 N/A physical interaction ComPPI
COL2A1 MMP2 25348397 N/A physical interaction ComPPI
COL2A1 FKBP9 25348397 N/A physical interaction ComPPI
COL2A1 CNPY2 25348397 N/A physical interaction ComPPI
COL2A1 COCH 19013156 24234451 25348397 N/A surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
TGFBI COL2A1 14525934 25348397 27898060 9061001 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
LOXL4 COL2A1 11292829 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
COLGALT2 COL2A1 25348397 N/A physical interaction ComPPI
COL2A1 COL2A1 14525934 8660302 N/A experimental interaction detection HPRD
FN1 COL2A1 14525934 2229073 3997552 N/A experimental interaction detection HPRD
MMP1 COL2A1 14525934 8609233 N/A experimental interaction detection HPRD
COL2A1 ITGA10 27898060 9685391 stimulant N/A OmniPath

Visualization










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