Gene Information gene info

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GENE：FLII

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FLII
FullNmae FLII actin remodeling protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3750
EnsembleID ENSG00000177731
Uniprot Q13045

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FLII ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FLII GO:0003779,GO:0005515,GO:0005546,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005903,GO:0005925,GO:0008154,GO:0015629,GO:0030239,GO:0034451,GO:0051014,GO:0051015,GO:0051016

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FLII NXNL1 20400501 23180781 physical association anti tag coimmunoprecipitation InnateDB
FLII NXNL2 20400501 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 FLII 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 FLII 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CTCF FLII 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 FLII 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FLII 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 FLII 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 FLII N/A trascriptional regulation,stimulation inferred by curator TFlink
CREB1 FLII N/A trascriptional regulation,stimulation inferred by curator TFlink
ETS2 FLII N/A trascriptional regulation,stimulation inferred by curator TFlink
ETV4 FLII N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 FLII N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A FLII N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE FLII 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 FLII 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC FLII 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016FF9C FLII 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 FLII 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
SGK3 FLII 22135298 phosphorylation N/A PhosphoSite
FLII LRRFIP2 25361965 interaction type N/A PTMCode2
LRRFIP2 FLII 25361965 interaction type N/A PTMCode2
FLII LRRFIP1 25361965 interaction type N/A PTMCode2
LRRFIP1 FLII 25361965 interaction type N/A PTMCode2
FLII ACTL6A 25361965 interaction type N/A PTMCode2
ACTL6A FLII 25361965 interaction type N/A PTMCode2
ACTL6B FLII 25361965 interaction type N/A PTMCode2
FLII ACTL6B 25361965 interaction type N/A PTMCode2
ACTR3 FLII 25361965 interaction type N/A PTMCode2
FLII ACTR3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRT18 FLII 25348397 N/A physical interaction ComPPI
ZNRD2 FLII 25348397 N/A physical interaction ComPPI
PPP1CC FLII 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTB FLII 14525934 25348397 9525888 N/A experimental interaction detection,in vitro ComPPI,HPRD
PPP1CB FLII 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KEAP1 FLII 25348397 N/A physical interaction ComPPI
OPTN FLII 10366446 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PRKDC FLII 25348397 N/A physical interaction ComPPI
GRB2 FLII 12577067 24234451 25348397 association pull down ComPPI,IntAct
JUN FLII 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
DHX9 FLII 25348397 N/A physical interaction ComPPI
FLNA FLII 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TUBG1 FLII 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSP90AA1 FLII 19875381 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NTRK1 FLII 25348397 N/A physical interaction ComPPI
PRMT1 FLII 14525934 14966289 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
FMNL1 FLII 25348397 N/A physical interaction ComPPI
RFC2 FLII 25348397 N/A physical interaction ComPPI
PPP1CA FLII 24234451 25348397 25593058 association anti bait coimmunoprecipitation ComPPI,IntAct
IQGAP1 FLII 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CFTR FLII 25348397 N/A physical interaction ComPPI
NPHP1 FLII 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MYO18A FLII 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK2 FLII 25348397 N/A physical interaction ComPPI
ACTL6A FLII 14525934 14966289 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TRAIP FLII 14525934 25348397 9671805 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
EIF1AX FLII 25348397 N/A physical interaction ComPPI
MYD88 FLII 14525934 16424162 19265123 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
PDCD6 FLII 25348397 N/A physical interaction ComPPI
CARM1 FLII 14525934 14966289 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
FLII LRRFIP1 10366446 14525934 24234451 25348397 9671805 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
FLII LRRFIP2 10366446 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
FLII DLST 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FLII GRIP1 14525934 14966289 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FLII ESR1 14525934 14966289 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FLII FBXO25 25348397 N/A physical interaction ComPPI
FLII DGCR8 25348397 N/A physical interaction ComPPI
FLII BRCA1 25348397 N/A physical interaction ComPPI
FLII HSP90AA2P 25348397 N/A physical interaction ComPPI
FLII PAN2 25348397 N/A physical interaction ComPPI
FLII RTCB 25348397 N/A physical interaction ComPPI
FLII DDX1 25348397 N/A physical interaction ComPPI
FLII EIF2B3 25348397 N/A physical interaction ComPPI
FLII HNRNPM 25348397 N/A physical interaction ComPPI
FLII IGF2BP3 25348397 N/A physical interaction ComPPI
FLII MRE11 25348397 N/A physical interaction ComPPI
FLII NMT1 25348397 N/A physical interaction ComPPI
FLII RFC4 25348397 N/A physical interaction ComPPI
FLII RPL27 25348397 N/A physical interaction ComPPI
FLII ALK 25348397 N/A physical interaction ComPPI
FLII CCDC8 25348397 N/A physical interaction ComPPI
FLII TMOD1 25348397 N/A physical interaction ComPPI
FLII FBXW11 25348397 N/A physical interaction ComPPI
FLII IFI16 25348397 N/A physical interaction ComPPI
FLII MED4 25348397 N/A physical interaction ComPPI
FLII MED20 25348397 N/A physical interaction ComPPI
FLII HERC2 25348397 N/A physical interaction ComPPI
FLII HERC2P3 25348397 N/A physical interaction ComPPI
FLII CEP89 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
FLII CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLII DBN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLII MYH9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLII MYO1C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLII NES 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLII SYNPO 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLII ANLN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLII MYO5C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLII MYO19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLII CFAP97 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLII SRSF5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLII TMOD3 25348397 N/A physical interaction ComPPI
FLII TMOD4 25348397 N/A physical interaction ComPPI
FLII NAT9 25348397 N/A physical interaction ComPPI
FLII CCND2 25348397 N/A physical interaction ComPPI
FLII PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
FLII RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
FLII BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
FLII PPP5C 24234451 25348397 28330616 association pull down ComPPI,IntAct
RTRAF FLII 25348397 N/A physical interaction ComPPI
FLII MYC 25348397 N/A physical interaction ComPPI
FLII N 24234451 25294943 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MATR3 FLII 24234451 30021884 physical association cross-linking study IntAct
AKAP8 FLII 24234451 30021884 physical association cross-linking study IntAct
SGK3 FLII 17081983 19293151 27898060 stimulant N/A OmniPath

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