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GENE：MTHFS

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MTHFS
FullNmae methenyltetrahydrofolate synthetase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7437
EnsembleID ENSG00000136371
Uniprot P49914

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MTHFS ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MTHFS GO:0005524,GO:0005542,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005829,GO:0006536,GO:0009396,GO:0015942,GO:0030272,GO:0030272,GO:0030272,GO:0030272,GO:0030272,GO:0035999,GO:0035999,GO:0046653,GO:0046655,GO:0046657,GO:0046872

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MTHFS hsa:10588 path:hsa00670 One carbon pool by folate - Homo sapiens (human)
MTHFS hsa:10588 path:hsa01100 Metabolic pathways - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 MTHFS 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 MTHFS 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MTHFS 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C MTHFS 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MTHFS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MTHFS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MTHFS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MTHFS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MTHFS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MTHFS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MTHFS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MTHFS 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 MTHFS 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
TSC22D4 MTHFS 14525934 16189514 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MTHFS NDUFS3 25348397 N/A physical interaction ComPPI
SFPQ MTHFS 24234451 30021884 physical association cross-linking study IntAct

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