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GENE：ALOX5AP

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ALOX5AP
FullNmae arachidonate 5-lipoxygenase activating protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:436
EnsembleID ENSG00000132965
Uniprot P20292

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ALOX5AP ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ALOX5AP GO:0002540,GO:0002675,GO:0004051,GO:0004364,GO:0004464,GO:0004602,GO:0005515,GO:0005635,GO:0005635,GO:0005635,GO:0005783,GO:0005783,GO:0005789,GO:0008047,GO:0016020,GO:0019370,GO:0019370,GO:0019372,GO:0019899,GO:0031965,GO:0042802,GO:0044877,GO:0050544,GO:0070207,GO:0071277,GO:0098869

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ALOX5AP hsa:241 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ALOX5AP LTC4S 19233132 23180781 physical association pull down InnateDB
ALOX5AP ALOX5 19233132 23180781 physical association pull down InnateDB
ALOX5AP CEBPA 12571239 23180781 physical association anti tag coimmunoprecipitation InnateDB
ALOX5AP CEBPD 12571239 23180781 physical association anti tag coimmunoprecipitation InnateDB
CEBPE ALOX5AP 12571239 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
CEBPA ALOX5AP 12571239 23180781 physical association electrophoretic mobility supershift assay InnateDB
CEBPD ALOX5AP 12571239 23180781 physical association electrophoretic mobility supershift assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR ALOX5AP 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA ALOX5AP 12571239 18971253 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
CEBPB ALOX5AP 12571239 trascriptional regulation,stimulation chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
CEBPD ALOX5AP 12571239 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
ETS1 ALOX5AP 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
NFKB1 ALOX5AP 15625306 20194722 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay,DNase I footprinting TFlink
YBX1 ALOX5AP 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 ALOX5AP 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ALOX5AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ALOX5AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ALOX5AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ALOX5AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ALOX5AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 ALOX5AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ALOX5AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ALOX5AP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A ALOX5AP 20448047 trascriptional regulation,stimulation inferred by curator TFlink
RELA ALOX5AP 20194722 trascriptional regulation,stimulation inferred by curator TFlink
CEBPE ALOX5AP N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A ALOX5AP N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005C1F22 ALOX5AP 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000259AE4 ALOX5AP 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000254A6 ALOX5AP 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 ALOX5AP 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 ALOX5AP 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC ALOX5AP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000753AD ALOX5AP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000008A99 ALOX5AP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003B6B84 ALOX5AP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000043C1C3 ALOX5AP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001FC26E ALOX5AP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001481F9 ALOX5AP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005CC20C ALOX5AP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 ALOX5AP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075BDAA ALOX5AP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000EC1BE ALOX5AP 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ALOX5 ALOX5AP 14525934 25348397 9445303 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CLIC1 ALOX5AP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FFAR2 ALOX5AP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FRA10AC1 ALOX5AP 25348397 N/A physical interaction ComPPI
LTC4S ALOX5AP 25348397 N/A physical interaction ComPPI
ALOX5AP NAPB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ALOX5AP GPR42 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ALOX5AP AQP6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMEM120B ALOX5AP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct

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