GENE：ICA1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ICA1 |
| FullNmae | islet cell autoantigen 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:5343 |
| EnsembleID | ENSG00000003147 |
| Uniprot | Q05084 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ICA1 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ICA1 | GO:0000139,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0005829,GO:0006836,GO:0019904,GO:0030667,GO:0030672,GO:0043231,GO:0051049,GO:0140090 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ICA1 | hsa:3382 | path:hsa04940 | Type I diabetes mellitus - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | ICA1 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | ICA1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | ICA1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | ICA1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | ICA1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | ICA1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | ICA1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| EXOC5 | ICA1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| STK16 | ICA1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| KRT33B | ICA1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CNTF | ICA1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PICK1 | ICA1 | 25348397 | N/A | physical interaction | ComPPI |
| MYC | ICA1 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| RAB2A | ICA1 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| MORF4L1 | ICA1 | 25348397 | N/A | physical interaction | ComPPI |
| ING5 | ICA1 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| MBD3 | ICA1 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |