GENE:ICA1
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | ICA1 |
FullNmae | islet cell autoantigen 1 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:5343 |
EnsembleID | ENSG00000003147 |
Uniprot | Q05084 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
ICA1 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
ICA1 | GO:0000139,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0005829,GO:0006836,GO:0019904,GO:0030667,GO:0030672,GO:0043231,GO:0051049,GO:0140090 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
ICA1 | hsa:3382 | path:hsa04940 | Type I diabetes mellitus - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
E2F4 | ICA1 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
ETS1 | ICA1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
GATA1 | ICA1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
GATA2 | ICA1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
YBX1 | ICA1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
FOXP3 | ICA1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
PRDM14 | ICA1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
SMARCA4 | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F1 | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXA1 | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
MITF | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
RUNX1 | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SPI1 | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TRIM28 | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TP53 | ICA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
EXOC5 | ICA1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
STK16 | ICA1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
KRT33B | ICA1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
CNTF | ICA1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
PICK1 | ICA1 | 25348397 | N/A | physical interaction | ComPPI |
MYC | ICA1 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
RAB2A | ICA1 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
MORF4L1 | ICA1 | 25348397 | N/A | physical interaction | ComPPI |
ING5 | ICA1 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
MBD3 | ICA1 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |