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GENE：DIS3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DIS3
FullNmae DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
LocusType gene with protein product
Status Approved
HGNC_id HGNC:20604
EnsembleID ENSG00000083520
Uniprot Q9Y2L1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DIS3 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DIS3 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DIS3 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DIS3 GO:0000175,GO:0000175,GO:0000175,GO:0000176,GO:0000176,GO:0000176,GO:0000177,GO:0000178,GO:0000178,GO:0003723,GO:0004519,GO:0004519,GO:0005085,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005829,GO:0006364,GO:0006396,GO:0006401,GO:0016020,GO:0016075,GO:0016075,GO:0043928,GO:0071034

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DIS3 hsa:22894 path:hsa03018 RNA degradation - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA2 DIS3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 DIS3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 DIS3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DIS3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 DIS3 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000016FD1A DIS3 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000021D7C8 DIS3 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00003AAF6D DIS3 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000075B538 DIS3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075D2F5 DIS3 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
EXOSC5 DIS3 11719186 14525934 20531386 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CUL5 DIS3 25348397 N/A physical interaction ComPPI
YJU2 DIS3 25348397 N/A physical interaction ComPPI
SH3GLB1 DIS3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DRG1 DIS3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TP53BP1 DIS3 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
RAN DIS3 25348397 N/A physical interaction ComPPI
KEAP1 DIS3 25348397 N/A physical interaction ComPPI
EXOSC1 DIS3 20531386 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC8 DIS3 11719186 14525934 15231747 20531386 24234451 25348397 association,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
JUN DIS3 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
CUL3 DIS3 25348397 N/A physical interaction ComPPI
KPNB1 DIS3 25348397 N/A physical interaction ComPPI
SCYL2 DIS3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NTRK1 DIS3 25348397 N/A physical interaction ComPPI
SUB1 DIS3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
STXBP3 DIS3 25348397 N/A physical interaction ComPPI
RCC1 DIS3 25348397 N/A physical interaction ComPPI
EXOSC10 DIS3 14525934 15231747 20531386 21255825 23756462 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CYP1A1 DIS3 25348397 N/A physical interaction ComPPI
EGFR DIS3 25348397 N/A physical interaction ComPPI
MTREX DIS3 11719186 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GTF2E2 DIS3 25348397 N/A physical interaction ComPPI
ZBTB17 DIS3 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RAVER1 DIS3 25348397 N/A physical interaction ComPPI
EXOSC6 DIS3 11719186 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
AICDA DIS3 25348397 N/A physical interaction ComPPI
CDK5 DIS3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DCX DIS3 25348397 N/A physical interaction ComPPI
FGB DIS3 25348397 N/A physical interaction ComPPI
DLX4 DIS3 25348397 N/A physical interaction ComPPI
EXOSC4 DIS3 11719186 14525934 20531386 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
GNAS DIS3 25348397 N/A physical interaction ComPPI
WDR1 DIS3 25348397 N/A physical interaction ComPPI
PPP5C DIS3 25348397 N/A physical interaction ComPPI
TWF1 DIS3 25348397 N/A physical interaction ComPPI
PALS2 DIS3 11719186 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
DIS3 EXOSC2 11719186 12972615 14525934 17173052 17391830 18314965 19879841 20531386 22833611 24234451 25348397 26344197 27898060 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct,OmniPath
DIS3 EXOSC9 20531386 24234451 25348397 association anti bait coimmunoprecipitation,two hybrid,physical interaction,in vivo ComPPI,IntAct
DIS3 EXOSC7 11719186 14525934 20531386 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
DIS3 BABAM1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DIS3 SIRT7 25348397 N/A physical interaction ComPPI
DIS3 SH3PXD2B 25348397 N/A physical interaction ComPPI
DIS3 NTMT1 15231747 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DIS3 NELFE 25348397 N/A physical interaction ComPPI
DIS3 SSBP3 25348397 N/A physical interaction ComPPI
DIS3 RBM23 25348397 N/A physical interaction ComPPI
DIS3 NMD3 25348397 N/A physical interaction ComPPI
DIS3 GNAS 25348397 N/A physical interaction ComPPI
DIS3 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DIS3 SEPTIN7 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DIS3 COPZ1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DIS3 PRCC 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DIS3 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DIS3 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
DIS3 RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MUS81 DIS3 25348397 N/A physical interaction ComPPI
SARNP DIS3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SNRNP27 DIS3 25348397 N/A physical interaction ComPPI
AHNAK DIS3 24234451 30021884 physical association cross-linking study IntAct
PLEC DIS3 24234451 30021884 physical association cross-linking study IntAct

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