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GENE：TNFRSF1B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TNFRSF1B
FullNmae TNF receptor superfamily member 1B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11917
EnsembleID ENSG00000028137
Uniprot P20333

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TNFRSF1B parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TNFRSF1B necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TNFRSF1B apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TNFRSF1B apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TNFRSF1B GO:0002718,GO:0002724,GO:0002724,GO:0002947,GO:0003176,GO:0003177,GO:0003332,GO:0005031,GO:0005515,GO:0005576,GO:0005886,GO:0006954,GO:0006955,GO:0008630,GO:0010614,GO:0016020,GO:0031625,GO:0031641,GO:0031643,GO:0031643,GO:0033209,GO:0035579,GO:0042129,GO:0042129,GO:0043025,GO:0043120,GO:0043120,GO:0043196,GO:0045121,GO:0048471,GO:0048714,GO:0048714,GO:0050779,GO:0051044,GO:0051044,GO:0071222,GO:0071363,GO:0097191,GO:0150077,GO:0150079,GO:0150079,GO:0150098,GO:1902339

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TNFRSF1B hsa:7133 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
TNFRSF1B hsa:7133 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
TNFRSF1B hsa:7133 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
TNFRSF1B hsa:7133 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
TNFRSF1B hsa:7133 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
TNFRSF1B hsa:7133 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
TNFRSF1B hsa:7133 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TRAF2 TNFRSF1B 10465784 11274345 11668179 12048245 12556535 12655147 12738796 15170913 15592525 17462996 17496911 18641653 18855897 19392652 21133840 21232017 21614932 23070005 23850759 24378531 26192618 9379049 9582321 interaction type N/A ACSN
MAP3K1 TNFRSF1B 10465784 11274345 11668179 12048245 12738796 15170913 15592525 17462996 17496911 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531 26192618 9379049 9582321 interaction type N/A ACSN
MAP3K5 TNFRSF1B 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531 26192618 interaction type N/A ACSN
TNFRSF1B MAP2K4 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531 26192618 interaction type N/A ACSN
TNFRSF1B MAP2K3 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531 26192618 interaction type N/A ACSN
TNFRSF1B MAP2K7 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531 26192618 interaction type N/A ACSN
TNFRSF1B MAP2K6 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531 26192618 interaction type N/A ACSN
TNFRSF1B TRAF2 15572357 23180781 8855313 9168896 physical association affinity chromatography technology,anti tag coimmunoprecipitation,gst pull down InnateDB
TRAF1 TNFRSF1B 18429822 23180781 9168896 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
BIRC2 TNFRSF1B 23180781 8548810 9718306 physical association anti tag coimmunoprecipitation,pull down InnateDB
TNFRSF1B TNF 11448951 14743216 19287455 23180781 physical association pull down,surface plasmon resonance,tandem affinity purification InnateDB
KRT8 TNFRSF1B 10747083 23180781 physical association pull down InnateDB
BMX TNFRSF1B 12370298 23180781 physical association anti tag coimmunoprecipitation InnateDB
ASB3 TNFRSF1B 15899873 23180781 physical association anti tag coimmunoprecipitation,antibody array InnateDB
MAPKAP1 TNFRSF1B 18687895 23180781 physical association anti tag coimmunoprecipitation InnateDB
PKN1 TNFRSF1B 18429822 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL6 TNFRSF1B 19965633 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF1B TNFRSF1B 26467481 8069916 interaction type,bind,up-regulates,up-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
AR TNFRSF1B 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 TNFRSF1B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 TNFRSF1B 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TNFRSF1B 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 TNFRSF1B 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 TNFRSF1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TNFRSF1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TNFRSF1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TNFRSF1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TNFRSF1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 TNFRSF1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TNFRSF1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TNFRSF1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TNFRSF1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 TNFRSF1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 TNFRSF1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 TNFRSF1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
JUN TNFRSF1B 9743209 trascriptional regulation,stimulation inferred by curator TFlink
RARA TNFRSF1B N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000367985 TNFRSF1B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 TNFRSF1B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 TNFRSF1B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000022B729 TNFRSF1B 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000017DBB8 TNFRSF1B 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000016FF9C TNFRSF1B 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
KRT18 TNFRSF1B 10747083 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HNRNPC TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HSPA8 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
VIM TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ACTG1 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
STAT1 TNFRSF1B 10848577 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TUBB TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TRAF6 TNFRSF1B 25348397 N/A physical interaction ComPPI
CALM1 TNFRSF1B 25348397 N/A tandem affinity purification ComPPI
SLC25A6 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TUFM TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EMC2 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SMURF2 TNFRSF1B 25348397 N/A physical interaction ComPPI
PRKDC TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
FLNA TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PKN1 TNFRSF1B 25348397 N/A physical interaction ComPPI
GRN TNFRSF1B 24070898 24234451 25348397 physical association two hybrid,pull down,surface plasmon resonance,solid phase assay,surface plasmon resonance array ComPPI,IntAct
KPNB1 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
GAPDH TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
IRS4 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PFKP TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
UBB TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
COPB1 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAV1 TNFRSF1B 11112773 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HAX1 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HSPA5 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HSP90B1 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TRAF3 TNFRSF1B 14525934 25348397 7859281 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TNFRSF1A TNFRSF1B 25348397 N/A physical interaction ComPPI
HNRNPU TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
DNAJA3 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
XPO5 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
C1QBP TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAD TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNF TNFRSF1B 14525934 14743216 19084540 2158863 24070898 24234451 25348397 7664431 physical association affinity chromatography technology,cross-linking study,experimental interaction detection,surface plasmon resonance,physical interaction,biochemical,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
FANCD2 TNFRSF1B 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
XPO1 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TRAF1 TNFRSF1B 14525934 24234451 25348397 8069916 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
TRAF2 TNFRSF1B 14525934 14743216 24234451 25348397 7639698 8069916 8702708 9461607 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification,two hybrid ComPPI,HPRD,IntAct
CLTC TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RPS18 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
IPO7 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
IPO8 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ATP1A1 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
BMX TNFRSF1B 12370298 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TCP1 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ADAM17 TNFRSF1B 25348397 N/A physical interaction ComPPI
CHUK TNFRSF1B 25348397 N/A physical interaction ComPPI
HSPA9 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK1 TNFRSF1B 25348397 N/A physical interaction ComPPI
TNFRSF1B TDP2 10764746 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
TNFRSF1B LTA 14525934 2160731 25348397 8123048 9552007 N/A cross-linking study,experimental interaction detection,physical interaction,biochemical,in vivo ComPPI,HPRD
TNFRSF1B CSNK1A1 14525934 25348397 7559483 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TNFRSF1B TRIM37 25348397 N/A physical interaction ComPPI
TNFRSF1B ASB3 25348397 N/A physical interaction ComPPI
TNFRSF1B TRADD 25348397 N/A physical interaction ComPPI
TNFRSF1B CD14 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TNFRSF1B UBQLN1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNFRSF1B ZNF420 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TNFRSF1B CSNK1A1L 25348397 27898060 8051045 N/A physical interaction ComPPI,OmniPath
TNFRSF1B BAG2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B AIFM1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B HSPA1L 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B TRIP13 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B DBT 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B RPS27L 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B SLC25A5 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B HACD3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B EPPK1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B PHGDH 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B RPS3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B MAD2L1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B HSPA6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B DNAJA1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B SLC1A3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B ATP5F1A 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B SSR4 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B SLC1A5 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B MYH10 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B GBF1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B SLC25A4 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B TIMM50 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B CDIPT 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B POTEKP 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B DDOST 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B XPOT 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B RCN2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B TUBB2B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B KCTD12 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B SERPINB3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B FANCI 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B MYO6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B HEATR6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B TUBB4A 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B ATAD3A 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B MON2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B GCN1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B MYH9 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B SLC25A3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B RPL38 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B CBWD2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B SEC61A1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B DDB1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B TUBA3C 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B ATP2A2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B SLC25A1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B SLC25A11 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B CSE1L 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B ATP2A1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B RPS16 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B RPS27 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B MYLK2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B XPNPEP3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TRAIP TNFRSF1B 14525934 25348397 9104814 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
RPL23 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EEF1A2 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RPS14 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HIVEP3 TNFRSF1B 11804591 14525934 N/A experimental interaction detection HPRD
TNFRSF1B TNFRSF1B 14743216 24234451 physical association tandem affinity purification IntAct
TNFRSF1B CALM2 14743216 24234451 physical association tandem affinity purification IntAct
CHUK TNFRSF1B 27898060 9535738 N/A N/A OmniPath
TNFRSF1B TRAF2 10206649 11112773 11907088 14743216 15572357 18161752 18671942 27898060 7544915 7639698 8069916 8548810 8702708 8710854 8855313 9162022 9168896 9461607 stimulant N/A OmniPath
TRAF2 TNFRSF1B 10206649 11112773 11907088 14743216 15572357 18671942 27898060 7544915 7639698 8069916 8548810 8702708 8710854 8855313 9162022 9168896 9461607 inhibition N/A OmniPath
TNF TNFRSF1B 11448951 12040173 1310388 1328224 14743216 15450251 15485837 19084540 19287455 2158863 2172983 24070898 27898060 7664431 7852363 7930591 7966397 8182064 8590321 8805640 9568681 stimulant N/A OmniPath
BIRC2 TNFRSF1B 27898060 8548810 9718306 N/A N/A OmniPath
TNFRSF1B TRAF1 18429822 27898060 7859281 8069916 8548810 9162022 9168896 stimulant N/A OmniPath
TNFRSF1B LINGO1 14966521 27898060 N/A N/A OmniPath

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