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GENE：GGA3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GGA3
FullNmae golgi associated, gamma adaptin ear containing, ARF binding protein 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17079
EnsembleID ENSG00000125447
Uniprot Q9NZ52

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GGA3 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GGA3 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
GGA3 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
GGA3 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GGA3 GO:0005515,GO:0005764,GO:0005794,GO:0005802,GO:0005802,GO:0006622,GO:0006886,GO:0006893,GO:0010008,GO:0030163,GO:0031267,GO:0031267,GO:0031647,GO:0031648,GO:0031901,GO:0032456,GO:0032991,GO:0034394,GO:0034394,GO:0035091,GO:0043001,GO:0043130,GO:0044877,GO:0045732,GO:0055038,GO:1902430

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GGA3 hsa:23163 path:hsa04142 Lysosome - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMARCA4 GGA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GGA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GGA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GGA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 GGA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 GGA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 GGA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 GGA3 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000EC1BE GGA3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 GGA3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 GGA3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CC864 GGA3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 GGA3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 GGA3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 GGA3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 GGA3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD GGA3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D GGA3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 GGA3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 GGA3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 GGA3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 GGA3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000F7766 GGA3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000029EBD GGA3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000052E1A6 GGA3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C GGA3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000393C7 GGA3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000610EFA GGA3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005ECFE5 GGA3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000184017 GGA3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D GGA3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C GGA3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 GGA3 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
M6PR GGA3 25361965 interaction type N/A PTMCode2
GGA3 M6PR 25361965 interaction type N/A PTMCode2
GGA3 ARF1 25361965 interaction type N/A PTMCode2
ARF1 GGA3 25361965 interaction type N/A PTMCode2
GGA3 CLTC 25361965 interaction type N/A PTMCode2
CLTC GGA3 25361965 interaction type N/A PTMCode2
GGA3 LAPTM5 25361965 interaction type N/A PTMCode2
LAPTM5 GGA3 25361965 interaction type N/A PTMCode2
GGA3 AP1S2 25361965 interaction type N/A PTMCode2
AP1S2 GGA3 25361965 interaction type N/A PTMCode2
GGA3 HGS 25361965 interaction type N/A PTMCode2
HGS GGA3 25361965 interaction type N/A PTMCode2
GGA3 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 GGA3 25361965 interaction type N/A PTMCode2
GGA3 IGF2R 25361965 interaction type N/A PTMCode2
IGF2R GGA3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
VPS11 GGA3 25348397 N/A physical interaction ComPPI
CRK GGA3 25348397 N/A physical interaction ComPPI
LAPTM5 GGA3 25348397 N/A physical interaction ComPPI
GGA2 GGA3 25348397 N/A physical interaction ComPPI
PACS1 GGA3 14525934 16977309 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CDKN2A GGA3 25348397 N/A physical interaction ComPPI
HGS GGA3 15611048 24234451 25348397 physical association two hybrid ComPPI,IntAct
ARF3 GGA3 25348397 N/A physical interaction ComPPI
UBB GGA3 15039775 24234451 25348397 physical association affinity chromatography technology,two hybrid ComPPI,IntAct
UBC GGA3 14660606 15494413 15701688 15966896 16135791 20484053 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RPS27A GGA3 14525934 15039775 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
CDH1 GGA3 25348397 N/A physical interaction ComPPI
CYTH2 GGA3 25348397 N/A physical interaction ComPPI
RABEP1 GGA3 12505986 12858162 14525934 14665628 16473621 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
TBC1D3 GGA3 25348397 N/A physical interaction ComPPI
TBC1D3C GGA3 25348397 N/A physical interaction ComPPI
CLTC GGA3 11301005 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ARF6 GGA3 23143332 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
MET GGA3 21664574 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ITCH GGA3 25348397 N/A physical interaction ComPPI
TSG101 GGA3 14525934 15039775 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
GGA3 AP1S2 12215646 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
GGA3 SYNRG 10814529 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
GGA3 AFTPH 14525934 14665628 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
GGA3 ARF1 10747089 11301005 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
GGA3 IGF2R 11387475 11390366 11859375 12032548 12060753 14525934 14567678 16135791 16977309 24234451 25348397 27898060 colocalization,physical association two hybrid,experimental interaction detection,pull down,physical interaction,imaging technique,in vitro ComPPI,HPRD,IntAct,OmniPath
GGA3 M6PR 11387475 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
GGA3 RNF11 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
GGA3 NEDD4 25348397 N/A physical interaction ComPPI
GGA3 VPS18 25348397 N/A physical interaction ComPPI
GGA3 CLINT1 25348397 N/A physical interaction ComPPI
GGA3 BACE1 25348397 N/A physical interaction ComPPI
GGA3 STAB1 25348397 N/A physical interaction ComPPI
GGA3 GGA1 25348397 N/A physical interaction ComPPI
GGA3 SORT1 25348397 N/A physical interaction ComPPI
GGA3 CDKN2A 25348397 N/A physical interaction ComPPI
GGA3 MON2 18418388 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GGA3 MOV10 25348397 N/A physical interaction ComPPI
GGA3 NXF1 25348397 N/A physical interaction ComPPI
GGA3 TOLLIP 25348397 N/A physical interaction ComPPI
GGA3 HAUS4 25348397 N/A physical interaction ComPPI
GGA3 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
GGA3 TGOLN2 16977309 24234451 25348397 29568061 colocalization,association imaging technique,proximity-dependent biotin identification ComPPI,IntAct
GGA3 BET1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GGA3 GGA3 10814529 14525934 N/A two hybrid HPRD

Visualization










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