GENE：BAK1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | BAK1 |
| FullNmae | BCL2 antagonist/killer 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:949 |
| EnsembleID | ENSG00000030110 |
| Uniprot | Q16611 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| BAK1 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BAK1 | pyroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| BAK1 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BAK1 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BAK1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BAK1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BAK1 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| BAK1 | GO:0001782,GO:0001783,GO:0001836,GO:0001836,GO:0001974,GO:0002262,GO:0002352,GO:0003674,GO:0005515,GO:0005739,GO:0005741,GO:0005741,GO:0005741,GO:0005741,GO:0005783,GO:0005829,GO:0006915,GO:0006915,GO:0008053,GO:0008285,GO:0008630,GO:0009410,GO:0009620,GO:0010046,GO:0010225,GO:0010248,GO:0010332,GO:0010524,GO:0010629,GO:0014070,GO:0015288,GO:0031018,GO:0031072,GO:0031100,GO:0031334,GO:0032469,GO:0032471,GO:0033137,GO:0034620,GO:0034644,GO:0034644,GO:0035108,GO:0042542,GO:0042802,GO:0042803,GO:0042803,GO:0043065,GO:0043065,GO:0044325,GO:0044346,GO:0044877,GO:0045471,GO:0045862,GO:0046872,GO:0046902,GO:0046930,GO:0046982,GO:0046982,GO:0048597,GO:0050673,GO:0051087,GO:0051400,GO:0051726,GO:0051881,GO:0060068,GO:0060402,GO:0070059,GO:0070242,GO:0071260,GO:0090200,GO:0090201,GO:0097136,GO:0097136,GO:0097145,GO:0097145,GO:0097190,GO:0097192,GO:0097193,GO:0097202,GO:1900103,GO:1901029,GO:1901030,GO:1902262,GO:1903896 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| BAK1 | hsa:578 | path:hsa01524 | Platinum drug resistance - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa04210 | Apoptosis - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05132 | Salmonella infection - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05160 | Hepatitis C - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05162 | Measles - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05164 | Influenza A - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05168 | Herpes simplex virus 1 infection - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05210 | Colorectal cancer - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05213 | Endometrial cancer - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05214 | Glioma - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05216 | Thyroid cancer - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05218 | Melanoma - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| BAK1 | hsa:578 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BCL2 | BAK1 | 11704864 17446862 22039431 23064052 23377657 23430059 23850759 26192618 8929532 | association | N/A | ACSN |
| BAK1 | VDAC2 | 12881569 19706873 22039431 23430059 23850759 26192618 | association | N/A | ACSN |
| MCL1 | BAK1 | 20501829 22039431 23430059 23850759 26192618 | interaction type | N/A | ACSN |
| EGR2 | BAK1 | 12687019 26192618 | interaction type | N/A | ACSN |
| BAK1 | TRAF2 | 22039431 23430059 23850759 26192618 | interaction type | N/A | ACSN |
| BCL2L1 | BAK1 | 22705850 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| VDAC2 | BAK1 | 22705850 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| BAK1 | BCL2A1 | 23180781 25416956 | physical association | two hybrid | InnateDB |
| BAK1 | BCL2L2 | 23180781 25416956 | physical association | two hybrid | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | BAK1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | BAK1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | BAK1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | BAK1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| CEBPA | BAK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | BAK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | BAK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | BAK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | BAK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | BAK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | BAK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| WWTR1 | BAK1 | 22470139 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00001F0C23 | BAK1 | 20616003 | rna interference,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS00001F0C23 | BAK1 | 20616003 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00000ED600 | BAK1 | 20215506 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00002A8BC6 | BAK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008B558 | BAK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A760 | BAK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | BAK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000137EDE | BAK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000019907A | BAK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AFAD1 | BAK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000035AC91 | BAK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001E0AEA | BAK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001DA458 | BAK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000321A1A | BAK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | BAK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003B59DF | BAK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A611 | BAK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000170CF4 | BAK1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000E1E9E | BAK1 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002D2333 | BAK1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000023F008 | BAK1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005E58C | BAK1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000585553 | BAK1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BE495 | BAK1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FC5B0 | BAK1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C85B2 | BAK1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B989F | BAK1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A7F58 | BAK1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EED18 | BAK1 | 25416803 28097098 | mrna cleavage,inhibition | array technology | TarBase |
| URS00006DE17B | BAK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001597DC | BAK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CF1D2 | BAK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D0BB4 | BAK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BMX | BAK1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BCL2L11 | BAK1 | 23374347 24234451 25348397 | physical association | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| BCL2L2 | BAK1 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| KRT31 | BAK1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BCL2L1 | BAK1 | 11175750 14525934 14596824 15292519 15901672 16189514 19060904 24234451 25348397 29997244 | physical association | anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,experimental interaction detection,scintillation proximity assay,physical interaction,two hybrid array,two hybrid pooling approach,in vitro,in vivo,luminescence based mammalian interactome mapping,two hybrid prey pooling approach | ComPPI,HPRD,IntAct |
| ARHGDIA | BAK1 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| AKAP13 | BAK1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| HERC1 | BAK1 | 25348397 | N/A | physical interaction | ComPPI |
| MCL1 | BAK1 | 10579309 10837489 14525934 15077116 15901672 17097560 18040043 19968986 20023629 21132008 22516262 23680104 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| VDAC1 | BAK1 | 10639121 14525934 24234451 25348397 9843949 | physical association | coimmunoprecipitation,experimental interaction detection,pull down,in vitro | ComPPI,HPRD,IntAct |
| NFKBIB | BAK1 | 25348397 | N/A | physical interaction | ComPPI |
| VDAC2 | BAK1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction,in vitro,in vivo | ComPPI,IntAct |
| MYCBP2 | BAK1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BCL2A1 | BAK1 | 10381646 14525934 24234451 25348397 25416956 | physical association | two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vivo,two hybrid prey pooling approach,validated two hybrid,two hybrid | ComPPI,HPRD,IntAct |
| BAK1 | BAX | 11571294 14525934 15901672 16439990 17289999 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| BAK1 | BCL2L10 | 14525934 25348397 9878060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| BAK1 | HSPD1 | 12070120 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| BAK1 | ERN1 | 14525934 16645094 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| BAK1 | MFN1 | 14525934 17606912 19168699 24234451 25348397 | association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| BAK1 | BCL2 | 11206074 11728179 14525934 24234451 25348397 26004684 9463381 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| BAK1 | FRYL | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BAK1 | FBL | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BAK1 | SRRM2 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BAK1 | DFFA | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BAK1 | ACTR2 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BAK1 | TP53 | 14525934 15077116 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| BAK1 | DBN1 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| BAK1 | TOMM40 | 25348397 | N/A | physical interaction | ComPPI |
| BAK1 | ABCB10 | 25348397 | N/A | physical interaction | ComPPI |
| BAK1 | HSD17B4 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| BAK1 | BID | 10950869 12624108 14525934 23604079 23782464 24234451 25348397 | physical association | anti bait coimmunoprecipitation,cosedimentation in solution,protein cross-linking with a bifunctional reagent,experimental interaction detection,nuclear magnetic resonance,physical interaction | ComPPI,HPRD,IntAct |
| BAK1 | GIMAP5 | 25348397 | N/A | physical interaction | ComPPI |
| BAK1 | MT-ND5 | 25348397 | N/A | physical interaction | ComPPI |
| BAK1 | MFN2 | 17606912 19168699 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BAK1 | UBE3A | 24234451 25348397 27898060 9881696 | physical association | anti tag coimmunoprecipitation,pull down | ComPPI,IntAct,OmniPath |
| BAK1 | BECN1 | 17446862 24234451 25348397 | physical association | fluorescence polarization spectroscopy | ComPPI,IntAct |
| BAK1 | RTL10 | 23055042 24234451 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| TOMM7 | BAK1 | 25348397 | N/A | physical interaction | ComPPI |
| BAK1 | BAK1 | 10579309 14525934 15077116 15901672 16439990 17446862 23782464 24234451 | physical association | anti tag coimmunoprecipitation,cross-linking study,experimental interaction detection,fluorescence polarization spectroscopy,chromatography technology,two hybrid | HPRD,IntAct |
| MAP2K4 | BAK1 | 16473966 27898060 | N/A | N/A | OmniPath |
| BCL2L1 | BAK1 | 10085290 11175750 12137781 14596824 15292519 15901672 16189514 17289999 18178565 19060904 22705850 27898060 9463381 | inhibition | N/A | OmniPath |
| BID | BAK1 | 10950869 11175253 12242151 12624108 17289999 23604079 23782464 27898060 | stimulant | N/A | OmniPath |
| BCL2 | BAK1 | 11206074 11728179 14980220 17289999 26004684 27898060 9463381 | inhibition | N/A | OmniPath |
| BAK1 | BAD | 27898060 9388232 | inhibition | N/A | OmniPath |
| SH3GLB1 | BAK1 | 16227588 27898060 | stimulant | N/A | OmniPath |
| BAK1 | VDAC1 | 10365962 10639121 27898060 9843949 | stimulant | N/A | OmniPath |
| BAK1 | CYCS | 11175253 11326099 11447222 11741880 12232790 27898060 | stimulant | N/A | OmniPath |
| TP53 | BAK1 | 15077116 21712378 25408501 27898060 | stimulant | N/A | OmniPath |
| MCL1 | BAK1 | 10579309 10837489 15077116 15637055 15901672 17097560 17289999 19148187 19968986 21613222 23680104 26186194 27898060 | inhibition | N/A | OmniPath |
| BAK1 | AIFM1 | 12232790 23003569 27898060 | stimulant | N/A | OmniPath |
| BCL2L11 | BAK1 | 12242151 22492984 27898060 | stimulant | N/A | OmniPath |
| BCL2L2 | BAK1 | 10381646 15901672 17289999 18178565 25416956 27898060 | inhibition | N/A | OmniPath |
| ERBB4 | BAK1 | 18676864 27898060 | stimulant | N/A | OmniPath |
| BAK1 | BAX | 11571294 15901672 16439990 21712378 27898060 | stimulant | N/A | OmniPath |
| BAK1 | HTRA2 | 12232790 14585074 27898060 | stimulant | N/A | OmniPath |
| BAK1 | ENDOG | 12232790 27898060 | stimulant | N/A | OmniPath |
| BAK1 | DIABLO | 12232790 12670926 12941691 14585074 27898060 | stimulant | N/A | OmniPath |
| VDAC2 | BAK1 | 12881569 17353931 22705850 27898060 | inhibition,stimulant | N/A | OmniPath |
| BBC3 | BAK1 | 17289999 22492984 27898060 | stimulant | N/A | OmniPath |
| BMX | BAK1 | 20959805 23189150 25649765 27898060 | N/A | N/A | OmniPath |
| PTPN5 | BAK1 | 20959805 27898060 | stimulant | N/A | OmniPath |