GENE：TREX1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TREX1 |
| FullNmae | three prime repair exonuclease 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:12269 |
| EnsembleID | ENSG00000213689 |
| Uniprot | Q9NSU2 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TREX1 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TREX1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TREX1 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TREX1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TREX1 | GO:0000287,GO:0001568,GO:0001822,GO:0002253,GO:0002281,GO:0002320,GO:0002383,GO:0002437,GO:0002457,GO:0002637,GO:0003007,GO:0003015,GO:0003228,GO:0003690,GO:0003697,GO:0005635,GO:0005737,GO:0005789,GO:0005789,GO:0005829,GO:0006091,GO:0006110,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006304,GO:0006308,GO:0006310,GO:0008250,GO:0008296,GO:0008296,GO:0008296,GO:0008301,GO:0008311,GO:0008340,GO:0008408,GO:0019217,GO:0031571,GO:0032197,GO:0032405,GO:0032407,GO:0032479,GO:0032508,GO:0032558,GO:0032680,GO:0032993,GO:0034614,GO:0035458,GO:0035781,GO:0042803,GO:0043277,GO:0043457,GO:0043596,GO:0045184,GO:0045824,GO:0046872,GO:0046890,GO:0050699,GO:0050727,GO:0050821,GO:0050863,GO:0051607,GO:0060337,GO:0060339,GO:0061635,GO:0071480,GO:0072711,GO:0097281,GO:1904161,GO:1905671 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TREX1 | hsa:11277 | path:hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | TREX1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | TREX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TREX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | TREX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | TREX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | TREX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CHCHD2 | TREX1 | 25348397 | N/A | physical interaction | ComPPI |
| KRTAP10-7 | TREX1 | 25348397 | N/A | physical interaction | ComPPI |
| SET | TREX1 | 25348397 | N/A | physical interaction | ComPPI |
| ATR | TREX1 | 25348397 | N/A | in vitro,in vivo | ComPPI |
| PRKDC | TREX1 | 25348397 | N/A | in vivo | ComPPI |
| RPA1 | TREX1 | 25348397 | N/A | in vitro | ComPPI |
| ATM | TREX1 | 25348397 | N/A | in vivo | ComPPI |
| TREX1 | NBN | 25348397 | N/A | in vivo | ComPPI |
| TREX1 | MSH2 | 25348397 | N/A | in vivo | ComPPI |
| TREX1 | RIBC2 | 25348397 | N/A | two hybrid,physical interaction | ComPPI |
| TREX1 | IFT20 | 25348397 | N/A | two hybrid,physical interaction | ComPPI |
| TREX1 | MCM7 | 25348397 | N/A | in vitro,in vivo | ComPPI |
| TREX1 | VKORC1 | 25348397 | N/A | physical interaction | ComPPI |
| TREX1 | MOV10 | 25348397 | N/A | physical interaction | ComPPI |
| TREX1 | NXF1 | 25348397 | N/A | physical interaction | ComPPI |
| TREX1 | UBQLN1 | 23979357 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| TREX1 | RAB23 | 25348397 | N/A | physical interaction | ComPPI |
| TREX1 | ACTA2 | 25348397 | N/A | physical interaction | ComPPI |
| SET | TREX1 | 16818237 27898060 | N/A | N/A | OmniPath |
| TREX1 | SET | 16818237 27898060 | N/A | N/A | OmniPath |