GENE：CASP9
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CASP9 |
| FullNmae | caspase 9 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1511 |
| EnsembleID | ENSG00000132906 |
| Uniprot | P55211 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CASP9 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CASP9 | pyroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CASP9 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CASP9 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CASP9 | apoptosis | 29365368 | CASP9 is an initiator caspase in the intrinsic apoptosis pathway, which in Casp9-/- mice has been shown to result in NTDs because of decreased apoptosis. | retulator signature |
| CASP9 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CASP9 | GO:0001666,GO:0001822,GO:0002931,GO:0004197,GO:0004197,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005829,GO:0006915,GO:0006915,GO:0006915,GO:0006919,GO:0006974,GO:0006974,GO:0008047,GO:0008233,GO:0008303,GO:0008630,GO:0008630,GO:0008635,GO:0016485,GO:0017124,GO:0019901,GO:0030220,GO:0032025,GO:0032355,GO:0032496,GO:0032991,GO:0034349,GO:0034644,GO:0042770,GO:0043065,GO:0043293,GO:0043293,GO:0043525,GO:0044346,GO:0051402,GO:0051604,GO:0071549,GO:0071887,GO:0097153,GO:0097193,GO:0097193,GO:0097193,GO:0097199,GO:0097199,GO:0097199,GO:1904019 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CASP9 | hsa:842 | path:hsa01524 | Platinum drug resistance - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa04210 | Apoptosis - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05012 | Parkinson disease - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05014 | Amyotrophic lateral sclerosis - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05016 | Huntington disease - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05134 | Legionellosis - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05160 | Hepatitis C - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05161 | Hepatitis B - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05162 | Measles - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05164 | Influenza A - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05168 | Herpes simplex virus 1 infection - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05210 | Colorectal cancer - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05213 | Endometrial cancer - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05215 | Prostate cancer - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05416 | Viral myocarditis - Homo sapiens (human) |
| CASP9 | hsa:842 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| XIAP | CASP9 | 11157976 11230124 11927604 12181739 15200957 15300255 23180781 25416956 9545235 | ubiquitination reaction,physical association | anti tag coimmunoprecipitation,two hybrid,gst pull down,ubiquitination reaction | InnateDB |
| UBE2D3 | CASP9 | 15749826 23180781 | ubiquitination reaction | ubiquitination reaction | InnateDB |
| CASP9 | CASP3 | 12181739 23180781 | physical association | gst pull down | InnateDB |
| CASP9 | XIAP | 12181739 16352606 23180781 | physical association | anti tag coimmunoprecipitation,gst pull down | InnateDB |
| RAF1 | CASP9 | 15674327 23180781 | cleavage reaction | protease assay | InnateDB |
| CASP3 | CASP9 | 12181739 12620238 17437405 23180781 8900201 | cleavage reaction,protein cleavage,physical association | affinity chromatography technology,protease assay | InnateDB |
| BIRC6 | CASP9 | 15300255 23180781 | ubiquitination reaction,physical association | anti tag coimmunoprecipitation,ubiquitination reaction | InnateDB |
| BIRC2 | CASP9 | 16339151 23180781 25416956 9545235 | physical association | two hybrid,gst pull down | InnateDB |
| BIRC3 | CASP9 | 16339151 23180781 9545235 | physical association | gst pull down | InnateDB |
| CASP9 | APAF1 | 16352606 19118655 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CASP9 | CASP7 | 16352606 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| HDAC7 | CASP9 | 18458084 23180781 | cleavage reaction | protease assay | InnateDB |
| ILK | CASP9 | 16936772 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PRKCZ | CASP9 | 16287866 23180781 | phosphorylation reaction | pull down,protein kinase assay | InnateDB |
| GZMB | CASP9 | 23180781 8900201 | protein cleavage | protease assay | InnateDB |
| MAPK3 | CASP9 | 12792650 23180781 | physical association | pull down | InnateDB |
| MAPK1 | CASP9 | 12792650 23180781 | phosphorylation reaction | protein kinase assay | InnateDB |
| PTCH1 | CASP9 | 19465923 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| APAF1 | CASP9 | 19337385 23180781 | physical association | two hybrid | InnateDB |
| EP300 | CASP9 | 15286281 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CASP9 | LGALS3 | 19118655 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CASP9 | VIM | 19118655 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CASP9 | EFHD2 | 19118655 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CASP9 | DDX58 | 23180781 23484008 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CASP9 | CASP9 | 15657060 26467481 9390557 | cleavage reaction,up-regulates activity | N/A | Signor |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MYC | CASP9 | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | CASP9 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | CASP9 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CASP9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CASP9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CASP9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CASP9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | CASP9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CASP9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RARA | CASP9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CASP9 | 20188076 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | CASP9 | 20056115 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | CASP9 | 20056115 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000AA464 | CASP9 | 20304954 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000003ABC4 | CASP9 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000B0E50 | CASP9 | 24805821 25416803 | mrna cleavage,inhibition | array technology,experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00000EED18 | CASP9 | 25416803 28097098 | mrna cleavage,inhibition | array technology | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKACA | CASP9 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK3 | CASP9 | 22135298 | phosphorylation | N/A | PhosphoSite |
| CDK1 | CASP9 | 22135298 | phosphorylation | N/A | PhosphoSite |
| ABL1 | CASP9 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK1 | CASP9 | 22135298 | phosphorylation | N/A | PhosphoSite |
| PRKCZ | CASP9 | 22135298 | phosphorylation | N/A | PhosphoSite |
| AKT1 | CASP9 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| BIRC7 | CASP9 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP9 | BIRC7 | 25361965 | interaction type | N/A | PTMCode2 |
| BCL2L1 | CASP9 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP9 | BCL2L1 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP9 | HIP1 | 25361965 | interaction type | N/A | PTMCode2 |
| HIP1 | CASP9 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP9 | XIAP | 25361965 | interaction type | N/A | PTMCode2 |
| XIAP | CASP9 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP9 | CASP8 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP8 | CASP9 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP9 | DCC | 25361965 | interaction type | N/A | PTMCode2 |
| DCC | CASP9 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP9 | BIRC6 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC6 | CASP9 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP9 | BIRC8 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC8 | CASP9 | 25361965 | interaction type | N/A | PTMCode2 |
| CYCS | CASP9 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP9 | CYCS | 25361965 | interaction type | N/A | PTMCode2 |
| CASP7 | CASP9 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP9 | CASP7 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP3 | CASP9 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP9 | CASP3 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP9 | AKT1 | 25361965 | interaction type | N/A | PTMCode2 |
| DIABLO | CASP9 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP9 | DIABLO | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC2 | CASP9 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP9 | BIRC2 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC3 | CASP9 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP9 | BIRC3 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CRYAB | CASP9 | 25348397 | N/A | physical interaction | ComPPI |
| VIM | CASP9 | 10469173 11423904 11514563 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| VCP | CASP9 | 25348397 | N/A | physical interaction | ComPPI |
| XIAP | CASP9 | 11242052 11390657 11801603 11927604 12620238 14525934 16189514 18022362 24234451 25241761 25348397 25416956 27107012 29997244 9545235 | association,physical association | anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,two hybrid,cosedimentation in solution,experimental interaction detection,fluorescence polarization spectroscopy,pull down,x-ray crystallography,physical interaction,two hybrid array,two hybrid pooling approach,biochemical,in vitro,in vivo,proximity ligation assay,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid | ComPPI,HPRD,IntAct |
| CASP9 | BIRC8 | 11390657 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CASP9 | MAP2K1 | 12792650 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| CASP9 | MAPK1 | 12792650 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| CASP9 | GMEB1 | 14525934 16497673 25348397 | N/A | two hybrid,experimental interaction detection,in vivo,two hybrid | ComPPI,HPRD |
| CASP9 | BCL2L1 | 14525934 24234451 25241761 25348397 9539746 | physical association | experimental interaction detection,physical interaction,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct |
| CASP9 | BIRC3 | 14525934 21988832 24234451 25241761 25348397 9545235 | physical association | two hybrid,experimental interaction detection,physical interaction,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct |
| CASP9 | CASP10 | 14525934 25348397 8962078 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| CASP9 | MAPK3 | 12792650 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| CASP9 | APAF1 | 10206961 10376594 14525934 19494828 20462491 21827945 24234451 25348397 9390557 9488720 9539746 9837928 9922454 | cleavage reaction,association,physical association | coimmunoprecipitation,cosedimentation,cosedimentation in solution,cosedimentation through density gradient,electron microscopy,experimental interaction detection,molecular sieving,pull down,x-ray crystallography,physical interaction,protease assay,in vitro,in vivo,protease accessibility laddering | ComPPI,HPRD,IntAct |
| CASP9 | BIRC5 | 11024045 11069302 14525934 24234451 25241761 25348397 | physical association | coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct |
| CASP9 | BIRC6 | 14525934 15300255 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| CASP9 | BIRC7 | 11024045 11084335 11801603 14525934 24234451 25348397 25416956 | physical association | anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,pull down,physical interaction,two hybrid array,in vivo,two hybrid prey pooling approach,validated two hybrid | ComPPI,HPRD,IntAct |
| CASP9 | NOD1 | 10329646 14525934 24234451 25348397 | physical association | coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| CASP9 | NLRP1 | 11076957 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CASP9 | CARD8 | 11408476 24234451 25348397 | physical association | coimmunoprecipitation,in vitro,in vivo | ComPPI,IntAct |
| CASP9 | MZB1 | 11350957 14525934 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| CASP9 | NAIP | 14525934 15280366 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CASP9 | HSPD1 | 11230124 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CASP9 | DCC | 11248093 14525934 16537496 19721007 24234451 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
| CASP9 | LYN | 12586738 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CASP9 | SRF | 11387340 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CASP9 | RB1 | 14525934 15735701 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| CASP9 | BIRC2 | 11084335 14525934 19153467 24234451 25241761 25348397 25416956 9545235 | physical association | anti tag coimmunoprecipitation,experimental interaction detection,surface plasmon resonance,x-ray crystallography,physical interaction,two hybrid array,in vitro,in vivo,proximity ligation assay,two hybrid prey pooling approach,validated two hybrid | ComPPI,HPRD,IntAct |
| CASP9 | PRKCZ | 14525934 16287866 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| CASP9 | CASP3 | 1067155 11230124 14525934 18723680 24234451 25241761 25348397 8900201 | cleavage reaction,association,physical association | experimental interaction detection,cleavage reaction,physical interaction,protease assay,in vitro,proximity ligation assay | ComPPI,HPRD,IntAct |
| CASP9 | CYCS | 12147322 14525934 24234451 25241761 25348397 | physical association | experimental interaction detection,physical interaction,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct |
| CASP9 | CAPN2 | 10671558 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CASP9 | DSP | 14525934 15500642 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CASP9 | ILK | 14525934 16936772 24234451 25348397 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,in vivo | ComPPI,HPRD,IntAct |
| CASP9 | DIABLO | 11242052 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CASP9 | HIP1 | 14525934 16979168 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| CASP9 | AKT1 | 14525934 25348397 9812896 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CASP9 | CASP8 | 25348397 | N/A | physical interaction | ComPPI |
| CASP9 | RNF2 | 25348397 | N/A | physical interaction | ComPPI |
| CASP9 | BRCA1 | 25348397 | N/A | physical interaction | ComPPI |
| CASP9 | MSTO1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| CASP9 | HSD17B4 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| CASP9 | JUN | 25348397 | N/A | physical interaction | ComPPI |
| CASP9 | CASP7 | 18723680 24234451 25348397 | cleavage reaction | cleavage reaction,physical interaction,protease assay | ComPPI,IntAct |
| CASP9 | SQSTM1 | 25348397 | N/A | physical interaction | ComPPI |
| CASP9 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| CASP9 | ABL1 | 14525934 15657060 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| CASP9 | BAX | 25348397 | N/A | physical interaction | ComPPI |
| CASP9 | RNF34 | 25348397 | N/A | physical interaction | ComPPI |
| CASP9 | CASP12 | 25348397 | N/A | physical interaction | ComPPI |
| CASP9 | ARNT | 25348397 | N/A | physical interaction | ComPPI |
| CASP9 | KAT6B | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| MAP2K2 | CASP9 | 12792650 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| BCL10 | CASP9 | 10187815 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| CASP9 | CASP9 | 12620238 14525934 9651578 | N/A | experimental interaction detection | HPRD |
| GZMB | CASP9 | 1067155 14525934 8900201 9651578 | N/A | experimental interaction detection | HPRD |
| PRKACA | CASP9 | 15703181 27898060 | inhibition | N/A | OmniPath |
| BCL2L1 | CASP9 | 25241761 27898060 9539746 | inhibition | N/A | OmniPath |
| APAF1 | CASP9 | 10206961 10329646 10364241 10376594 10393175 10428850 10617566 10722681 10749135 11113115 11242052 15262985 15829969 16352606 19118655 19337385 19494828 19698783 20829884 27898060 9390557 9488720 9539746 9651578 9837928 9922454 | stimulant | N/A | OmniPath |
| MAP2K1 | CASP9 | 12792650 18669648 27898060 | N/A | N/A | OmniPath |
| CASP9 | CASP7 | 16352606 17899380 27898060 9598997 9651578 9922454 | stimulant | N/A | OmniPath |
| CASP3 | CASP9 | 1067155 11230124 11242052 12181739 12620238 14585074 15507451 15657060 17437405 18723680 25241761 27898060 8900201 9390557 | stimulant | N/A | OmniPath |
| CASP9 | CASP3 | 1067155 10708865 11230124 11242052 12181739 12620238 14585074 15507451 15657060 15725726 17437405 18723680 25241761 27898060 8900201 9390557 9708736 | stimulant | N/A | OmniPath |
| CASP9 | BIRC6 | 15200957 15300255 15507451 27898060 | inhibition | N/A | OmniPath |
| BIRC6 | CASP9 | 15200957 15300255 15507451 27898060 | inhibition | N/A | OmniPath |
| MAP2K2 | CASP9 | 12792650 18669648 27898060 | N/A | N/A | OmniPath |
| GSN | CASP9 | 10660524 27898060 | inhibition | N/A | OmniPath |
| AKT1 | CASP9 | 10529400 11714830 15004527 16341064 18840507 27898060 9812896 | inhibition | N/A | OmniPath |
| XIAP | CASP9 | 10508158 11157976 11230124 11242052 11390657 11801603 11927604 12042762 12181739 12620238 14512414 14523016 15069192 15200957 15280366 15300255 15507451 15749826 16189514 16322207 16352606 16701639 17179183 17291493 18022362 19153467 19698783 23074197 25241761 25416956 27898060 9545235 | inhibition | N/A | OmniPath |
| CASP12 | CASP9 | 12097332 15725726 27898060 | stimulant | N/A | OmniPath |
| CAPN2 | CASP9 | 10671558 27898060 | N/A | N/A | OmniPath |
| CARD8 | CASP9 | 11408476 16678772 27898060 | inhibition | N/A | OmniPath |
| MAPK3 | CASP9 | 12792650 18669648 27898060 | inhibition | N/A | OmniPath |
| CASP9 | MAPK3 | 12792650 27898060 | N/A | N/A | OmniPath |
| CYCS | CASP9 | 12147322 25241761 27898060 9390557 | stimulant | N/A | OmniPath |
| CASP9 | PRKCZ | 16287866 27898060 | N/A | N/A | OmniPath |
| PRKCZ | CASP9 | 15703181 16287866 27898060 | inhibition | N/A | OmniPath |
| ABL1 | CASP9 | 15657060 20841568 27898060 9812896 | stimulant | N/A | OmniPath |
| CASP8 | CASP9 | 10988287 11832478 27898060 8962078 | stimulant | N/A | OmniPath |
| CDK1 | CASP9 | 16287866 17466630 27898060 | inhibition | N/A | OmniPath |
| RAF1 | CASP9 | 15674327 27898060 | N/A | N/A | OmniPath |
| CASP9 | CASP6 | 12097334 14686614 16521476 27898060 9651578 | stimulant | N/A | OmniPath |
| BIRC2 | CASP9 | 11084335 15069192 16339151 16701639 19153467 25241761 25416956 27898060 9545235 9990849 | inhibition | N/A | OmniPath |
| PPP1CA | CASP9 | 16888006 22311969 27898060 | stimulant | N/A | OmniPath |
| BIRC3 | CASP9 | 15069192 16339151 16701639 21988832 25241761 27898060 9545235 9990849 | inhibition | N/A | OmniPath |
| MAPK1 | CASP9 | 12792650 18669648 27898060 | inhibition | N/A | OmniPath |
| AKT3 | CASP9 | 27898060 9812896 | inhibition | N/A | OmniPath |
| DDX58 | CASP9 | 23484008 27898060 | N/A | N/A | OmniPath |
| CASP9 | VIM | 10469173 11423904 11514563 19118655 27898060 | stimulant | N/A | OmniPath |
| BIRC5 | CASP9 | 11024045 11069302 25241761 27898060 | inhibition | N/A | OmniPath |
| AKT2 | CASP9 | 15004527 27898060 9812896 | inhibition,stimulant | N/A | OmniPath |
| DIABLO | CASP9 | 10929711 11242052 27898060 | stimulant | N/A | OmniPath |
| NAIP | CASP9 | 15280366 27898060 | inhibition | N/A | OmniPath |
| BIRC8 | CASP9 | 11390657 25416956 27898060 | inhibition | N/A | OmniPath |