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GENE：HTR4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HTR4
FullNmae 5-hydroxytryptamine receptor 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5299
EnsembleID ENSG00000164270
Uniprot Q13639

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HTR4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HTR4 GO:0004993,GO:0004993,GO:0005515,GO:0005737,GO:0005768,GO:0005886,GO:0005886,GO:0007186,GO:0007187,GO:0007268,GO:0016020,GO:0030277,GO:0030425,GO:0030594,GO:0032098,GO:0045202,GO:0070254,GO:0098664,GO:0099589,GO:0120056

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HTR4 hsa:3360 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
HTR4 hsa:3360 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
HTR4 hsa:3360 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
HTR4 hsa:3360 path:hsa04726 Serotonergic synapse - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HTR4 HTR4 15896782 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA1 HTR4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 HTR4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 HTR4 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 HTR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HTR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HTR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HTR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HTR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HTR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 HTR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 HTR4 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A HTR4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
ADRB2 HTR4 25361965 interaction type N/A PTMCode2
HTR4 ADRB2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ADRB2 HTR4 15896782 24234451 25348397 27898060 physical association bioluminescence resonance energy transfer,in vitro ComPPI,IntAct,OmniPath
HTR4 HTR4 15896782 24234451 physical association anti bait coimmunoprecipitation,bioluminescence resonance energy transfer IntAct
HTR4 GPRIN2 24234451 28298427 physical association anti tag coimmunoprecipitation,ubiquitin reconstruction IntAct
HTR4 GPR37 24234451 28298427 colocalization,physical association anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,ubiquitin reconstruction,imaging technique IntAct
HTR4 CERS1 24234451 28298427 physical association ubiquitin reconstruction IntAct
HTR4 ANO10 24234451 28298427 physical association ubiquitin reconstruction IntAct
HTR4 GHITM 24234451 28298427 physical association ubiquitin reconstruction IntAct
HTR4 GDF1 24234451 28298427 physical association ubiquitin reconstruction IntAct
HTR4 CLTB 24234451 28298427 physical association ubiquitin reconstruction IntAct
HTR4 CD81 24234451 28298427 physical association ubiquitin reconstruction IntAct
HTR4 TMEM230 24234451 28298427 physical association ubiquitin reconstruction IntAct
HTR4 GGT7 24234451 28298427 physical association ubiquitin reconstruction IntAct
HTR4 SARAF 24234451 28298427 physical association ubiquitin reconstruction IntAct
TMEFF2 HTR4 24234451 28298427 physical association ubiquitin reconstruction IntAct
HTR4 TSPAN7 24234451 28298427 physical association ubiquitin reconstruction IntAct
HTR4 SLC39A1 24234451 28298427 physical association ubiquitin reconstruction IntAct
HTR4 ELOVL5 24234451 28298427 physical association ubiquitin reconstruction IntAct
HTR4 MGLL 24234451 28298427 physical association ubiquitin reconstruction IntAct
HTR4 CLDN10 24234451 28298427 physical association ubiquitin reconstruction IntAct
TPH1 HTR4 10953292 27898060 stimulant N/A OmniPath

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