GENE：AOC1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | AOC1 |
| FullNmae | amine oxidase copper containing 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:80 |
| EnsembleID | ENSG00000002726 |
| Uniprot | P19801 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| AOC1 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| AOC1 | cuproptosis | N/A | Ultimately, the twenty genes including ATP7A, SLC25A3, SCO2, COA6, AOC1, TMEM199, ATP6AP1, FDX1, LIPT1, DLAT, PDHA1, MTF1, MT-CO1, ACO1, ACP1, FDX2, NUBP2, CIAPIN1, ISCA2, and NDOR1 were used for eventually screened cuproptosis-related genes in later study. | retulator signature |
| AOC1 | cuproptosis | 35964468 | By LASSO and COX regressions, 18 prognosis-related cuproptosis genes were further selected and their HR was obtained. | cuproptosis-related genes |
| AOC1 | cuproptosis | 35964468 | Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). | Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.3 database. |
| AOC1 | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. | Genes related to copper homeostasis pathway |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| AOC1 | GO:0005507,GO:0005507,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005777,GO:0005886,GO:0005886,GO:0005886,GO:0005923,GO:0008131,GO:0008131,GO:0008201,GO:0008270,GO:0009308,GO:0009445,GO:0035580,GO:0035874,GO:0042803,GO:0044877,GO:0046677,GO:0046677,GO:0048038,GO:0052597,GO:0052597,GO:0052598,GO:0052599,GO:0052600,GO:0070062,GO:0070062,GO:0071280,GO:0071420,GO:0071504,GO:0097185 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| AOC1 | hsa:26 | path:hsa00330 | Arginine and proline metabolism - Homo sapiens (human) |
| AOC1 | hsa:26 | path:hsa00340 | Histidine metabolism - Homo sapiens (human) |
| AOC1 | hsa:26 | path:hsa00380 | Tryptophan metabolism - Homo sapiens (human) |
| AOC1 | hsa:26 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | AOC1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | AOC1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | AOC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | AOC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | AOC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | AOC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | AOC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | AOC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | AOC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | AOC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | AOC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| POGZ | AOC1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| FGD1 | AOC1 | 12913069 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| FOXH1 | AOC1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NTAQ1 | AOC1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| DNM2 | AOC1 | 12419186 14525934 | N/A | experimental interaction detection | HPRD |
| AURKA | AOC1 | 11668184 14737190 18006656 19590096 27898060 | N/A | N/A | OmniPath |