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GENE：GSTM4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GSTM4
FullNmae glutathione S-transferase mu 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4636
EnsembleID ENSG00000168765
Uniprot Q03013

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GSTM4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GSTM4 GO:0004364,GO:0004364,GO:0004464,GO:0005515,GO:0005737,GO:0005829,GO:0005829,GO:0006749,GO:0006749,GO:0018916,GO:0019899,GO:0042178,GO:0042759,GO:0042803,GO:0043295,GO:0045171

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GSTM4 hsa:2948 path:hsa00480 Glutathione metabolism - Homo sapiens (human)
GSTM4 hsa:2948 path:hsa00980 Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)
GSTM4 hsa:2948 path:hsa00982 Drug metabolism - cytochrome P450 - Homo sapiens (human)
GSTM4 hsa:2948 path:hsa00983 Drug metabolism - other enzymes - Homo sapiens (human)
GSTM4 hsa:2948 path:hsa01100 Metabolic pathways - Homo sapiens (human)
GSTM4 hsa:2948 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
GSTM4 hsa:2948 path:hsa05200 Pathways in cancer - Homo sapiens (human)
GSTM4 hsa:2948 path:hsa05204 Chemical carcinogenesis - DNA adducts - Homo sapiens (human)
GSTM4 hsa:2948 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
GSTM4 hsa:2948 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
GSTM4 hsa:2948 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
GSTM4 hsa:2948 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 GSTM4 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 GSTM4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 GSTM4 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF GSTM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GSTM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GSTM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GSTM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005E6F45 GSTM4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000411672 GSTM4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001FA076 GSTM4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 GSTM4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000C36BD GSTM4 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
BAG3 GSTM4 25348397 N/A physical interaction ComPPI
TLE1 GSTM4 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
UNC119 GSTM4 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NELFCD GSTM4 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ZBTB16 GSTM4 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RIF1 GSTM4 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
GSTM4 APLP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GSTM4 TP53 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct

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