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GENE：BCL3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BCL3
FullNmae BCL3 transcription coactivator
LocusType gene with protein product
Status Approved
HGNC_id HGNC:998
EnsembleID ENSG00000069399
Uniprot P20749

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BCL3 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL3 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
BCL3 GO:0002268,GO:0002315,GO:0002455,GO:0002467,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006606,GO:0006974,GO:0007249,GO:0009615,GO:0010225,GO:0019730,GO:0030198,GO:0030330,GO:0030496,GO:0030674,GO:0032088,GO:0032717,GO:0032720,GO:0032729,GO:0032733,GO:0032991,GO:0032996,GO:0033257,GO:0033257,GO:0042088,GO:0042742,GO:0042771,GO:0042826,GO:0042826,GO:0042832,GO:0042981,GO:0042981,GO:0043066,GO:0043231,GO:0045064,GO:0045727,GO:0045892,GO:0045893,GO:0045944,GO:0046426,GO:0048471,GO:0048536,GO:0051101,GO:0070231,GO:0070233,GO:0140297,GO:0140297,GO:1901222

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BCL3 hsa:602 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
BCL3 hsa:602 path:hsa04668 TNF signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HDAC1 BCL3 10754326 10952726 11875494 12907458 14660645 14668329 15465827 15644117 16878026 17404308 17485448 21234400 22796940 23390297 26192618 7594497 association N/A ACSN
BCL3 IL2 12907458 14668329 15079071 15465827 15536066 17145890 17404308 19171876 20138012 23430059 26192618 8383323 8580069 interaction type N/A ACSN
BCL3 IL10 12907458 14668329 15465827 15749884 16713974 17404308 20547845 26192618 interaction type N/A ACSN
BCL3 IL1B 12907458 14668329 15465827 15749884 16713974 17404308 20547845 26192618 interaction type N/A ACSN
BCL3 TNF 10754326 10952726 11875494 12907458 14660645 14668329 15079071 15465827 15536066 15644117 16878026 17145890 17404308 17485448 19171876 20138012 23390297 23430059 26192618 7594497 8383323 8580069 interaction type N/A ACSN
STAT3 BCL3 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 26192618 27216177 28186502 7543512 interaction type N/A ACSN
BCL3 NFKB2 12808109 16108830 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFKB1 BCL3 16108830 18668140 23180781 25089799 physical association anti tag coimmunoprecipitation InnateDB
BCL3 BCL10 16280327 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
BCL10 BCL3 20235165 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL3 CTBP2 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL3 BIRC2 23180781 25089799 physical association anti tag coimmunoprecipitation InnateDB
BCL3 BIRC3 23180781 25089799 physical association anti tag coimmunoprecipitation InnateDB
BCL3 CXCL8 23180781 25089799 physical association anti tag coimmunoprecipitation InnateDB
BCL3 IL17A 23180781 25089799 physical association anti tag coimmunoprecipitation InnateDB
RELA BCL3 23180781 25089799 physical association anti tag coimmunoprecipitation InnateDB
NFKB2 BCL3 23180781 25089799 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR BCL3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 BCL3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 BCL3 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC BCL3 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C BCL3 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 BCL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BCL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BCL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS BCL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BCL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BCL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 BCL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 BCL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 BCL3 11387332 trascriptional regulation,stimulation inferred by curator TFlink
RELA BCL3 11387332 trascriptional regulation,stimulation inferred by curator TFlink
TP53 BCL3 12808109 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 BCL3 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000BB229 BCL3 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000006FDD4 BCL3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000058DCD8 BCL3 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 BCL3 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003ACE11 BCL3 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005FDE70 BCL3 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000321A1A BCL3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000024CEE0 BCL3 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GSK3A BCL3 22135298 phosphorylation N/A PhosphoSite
BCL3 NFKB2 25361965 interaction type N/A PTMCode2
NFKB2 BCL3 25361965 interaction type N/A PTMCode2
BCL3 RELB 25361965 interaction type N/A PTMCode2
RELB BCL3 25361965 interaction type N/A PTMCode2
BCL3 NFKB1 25361965 interaction type N/A PTMCode2
NFKB1 BCL3 25361965 interaction type N/A PTMCode2
BCL3 N4BP2 25361965 interaction type N/A PTMCode2
N4BP2 BCL3 25361965 interaction type N/A PTMCode2
BCL3 STAT3 25361965 interaction type N/A PTMCode2
STAT3 BCL3 25361965 interaction type N/A PTMCode2
BCL3 BCL10 25361965 interaction type N/A PTMCode2
BCL10 BCL3 25361965 interaction type N/A PTMCode2
BCL3 CYLD 25361965 interaction type N/A PTMCode2
CYLD BCL3 25361965 interaction type N/A PTMCode2
BCL3 GSK3B 25361965 interaction type N/A PTMCode2
GSK3B BCL3 25361965 interaction type N/A PTMCode2
BCL3 KAT5 25361965 interaction type N/A PTMCode2
KAT5 BCL3 25361965 interaction type N/A PTMCode2
BCL3 GTF2B 25361965 interaction type N/A PTMCode2
GTF2B BCL3 25361965 interaction type N/A PTMCode2
BCL3 JUN 25361965 interaction type N/A PTMCode2
JUN BCL3 25361965 interaction type N/A PTMCode2
BCL3 PIR 25361965 interaction type N/A PTMCode2
PIR BCL3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAPRE1 BCL3 25348397 N/A physical interaction ComPPI
STAT1 BCL3 25348397 N/A physical interaction ComPPI
GTF2A1 BCL3 14525934 25348397 9812988 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GTF2B BCL3 14525934 25348397 9812988 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAPK1 BCL3 25348397 N/A physical interaction ComPPI
TBP BCL3 14525934 25348397 9812988 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
LCK BCL3 16099425 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down ComPPI,IntAct
SHC1 BCL3 11707390 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAPK3 BCL3 14525934 15469820 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
JUN BCL3 10497212 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CREBBP BCL3 10497212 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NCOA1 BCL3 10497212 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
EP300 BCL3 25348397 N/A physical interaction ComPPI
COPS5 BCL3 10362352 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HDAC3 BCL3 14525934 15469820 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CTBP1 BCL3 25348397 N/A physical interaction ComPPI
CTBP2 BCL3 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
GSK3B BCL3 14525934 15469820 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RUVBL1 BCL3 25348397 N/A physical interaction ComPPI
PIR BCL3 10362352 24234451 25348397 25680527 27898060 N/A pull down,physical interaction ComPPI,IntAct,OmniPath
GSK3A BCL3 14525934 15469820 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HSPA4 BCL3 25348397 N/A physical interaction ComPPI
HDAC6 BCL3 14525934 15469820 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CTNNB1 BCL3 14525934 15829968 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CHUK BCL3 25348397 N/A physical interaction ComPPI
FYN BCL3 14525934 16099425 24234451 25348397 9576921 physical association experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
RAB9A BCL3 11485202 11707390 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
BCL3 NFKB1 10362352 14525934 14678988 17962807 25348397 8428580 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
BCL3 NFKB2 11707390 14525934 17962807 25348397 8453667 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BCL3 BARD1 10362352 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
BCL3 N4BP2 12730195 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BCL3 RUVBL2 14525934 15829968 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BCL3 KAT5 10362352 14525934 15829968 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
BCL3 RELB 25348397 N/A physical interaction ComPPI
BCL3 FOS 10497212 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BCL3 RXRA 14525934 25348397 9812988 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
BCL3 CYLD 25348397 N/A physical interaction ComPPI
BCL3 STAT3 25348397 N/A physical interaction ComPPI
BCL3 HDAC1 14525934 15469820 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BCL3 BAG2 25348397 N/A physical interaction ComPPI
BCL3 RCOR1 25348397 N/A physical interaction ComPPI
BCL3 KDM1A 25348397 N/A physical interaction ComPPI
BCL3 FBXW8 25348397 N/A physical interaction ComPPI
BCL3 ESR1 25348397 N/A physical interaction ComPPI
BCL3 AKT1 25348397 N/A physical interaction ComPPI
BCL3 ANKRD28 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
BCL10 BCL3 16280327 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TBL1XR1 BCL3 25348397 N/A physical interaction ComPPI
PSMB1 BCL3 25348397 N/A physical interaction ComPPI
CYLD BCL3 16713561 27898060 inhibition N/A OmniPath
NFKB1 BCL3 10362352 10453354 10469655 11931770 14678988 15829968 16108830 16513645 17561400 17962807 18668140 20547759 20558726 20800578 25089799 27898060 8330739 8428580 9218802 N/A N/A OmniPath
BCL3 NFKB1 10362352 10453354 10469655 11931770 14678988 15829968 16108830 16513645 17183360 17561400 17962807 18668140 20547759 20558726 20800578 21912613 25089799 27898060 8330739 8428580 9218802 stimulant N/A OmniPath
BCL3 HDAC3 15469820 20547759 27898060 stimulant N/A OmniPath
GSK3A BCL3 15469820 27898060 inhibition,stimulant N/A OmniPath
BCL3 HDAC1 15469820 16306601 27898060 stimulant N/A OmniPath
TBL1XR1 BCL3 20547759 27898060 inhibition N/A OmniPath
RELA BCL3 25089799 27898060 N/A N/A OmniPath
BCL3 NFKB2 10362352 10453354 11707390 12808109 14668329 14678988 15371334 15465827 16108830 16513645 16713561 17072322 17183360 17349209 17962807 20558726 20800578 27898060 8453667 9405619 stimulant N/A OmniPath
NFKB2 BCL3 10362352 10453354 11707390 12808109 14668329 14678988 15371334 15465827 16108830 16513645 17072322 17349209 17962807 20558726 20800578 25089799 27898060 8453667 9405619 N/A N/A OmniPath
CRTC3 BCL3 17644518 27898060 stimulant N/A OmniPath

Visualization










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